Research Idea Wiki Page: Difference between revisions
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Jiawen Wei (talk | contribs) |
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===Background Information=== | ===Background Information=== | ||
CCR5 is a receptor on the outside of T cells that HIV uses to dalfdlsakjflas;kfjdlas;kfjs | |||
CCR5 delta 32 is an isoform of CCR5 found in certain Northern European individuals that confers resistance, or immunity, to HIV. | |||
Zinc Finger nucleases are tools that can be used to modify the human genome in a very target specific manner. Homology repair is a mechanism that cells use to repair damaged DNA. It is a mechanism that can be used to introduce new modified DNA sequences into the genome at very specific target locations. | |||
===Purpose and Goals=== | ===Purpose and Goals=== |
Revision as of 01:39, 8 May 2013
Project Overview
We are looking to use zinc finger nucleases to modify the CCR5 receptor on genetically haploid cells to identify the role of CCR5 in HIV infection and to explore the possibility of generating immunity to HIV.
Background Information
CCR5 is a receptor on the outside of T cells that HIV uses to dalfdlsakjflas;kfjdlas;kfjs CCR5 delta 32 is an isoform of CCR5 found in certain Northern European individuals that confers resistance, or immunity, to HIV. Zinc Finger nucleases are tools that can be used to modify the human genome in a very target specific manner. Homology repair is a mechanism that cells use to repair damaged DNA. It is a mechanism that can be used to introduce new modified DNA sequences into the genome at very specific target locations.