Renhao Li Lab:Publications

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2011

27. W. Deng, S. Srinivasan, X. Zheng, J. A. Putkey, R. Li. Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding. J. Mol. Biol.

26. S. Srinivasan, W. Deng, R. Li.

L-selectin transmembrane and cytoplasmic domains are monomeric in membranes.

Biochim. Biophys. Acta 1808: 1709-1715, 2011.

25. Z. Zhou, H.-C. Yeh, H. Jing, C. Wang, Z. Tao, H. Choi, K. Aboulfatova, R. Li, J.-F. Dong.

Cysteine residues in CUB-1 domain are critical for ADAMTS13 secretion and stability.

Thromb. Haemost. 105: 21-30, 2011.

2010

24. X. Mo, N. X. Nguyen, F.-T. Mu, W. Yang, S.-Z. Luo, H. Fan, R. K. Andrews, M. C. Berndt, R. Li.

Trans-membrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibα.

J. Biol. Chem. 285: 32096-32104, 2010.

23. R. Li.

A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia.

Blood 115: 914, 2010.

2009

22. X. Mo, N. X. Nguyen, P. A. McEwan, X. Zheng, J. A. López, J. Emsley, R. Li.

Binding of platelet glycoprotein Ibβ through the convex surface of leucine-rich repeats domain of glycoprotein IX.

J. Thromb. Haemost. 7: 1533-1540, 2009.

21. Z. Zhou, H. Jing, Z. Tao, H. Choi, K. Aboulfatova, J. Moake, R. Li, J.-F. Dong.

Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13.

Thromb. Res. 124: 323-327, 2009.

2008

20. X. Mo, S.-Z. Luo, J. A. López, R. Li.

Juxtamembrane basic residues in the glycoprotein Ibβ cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex.

FEBS Lett. 582: 3270-3274, 2008.

19. S.-Z. Luo, R. Li.

Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complex.

J. Mol. Biol. 382: 448-457, 2008.

18. X. Mo, S.-Z. Luo, A. D. Munday, W. Sun, M. C. Berndt, J. A. López, J.-F. Dong, R. Li.

The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence receptor binding to von Willebrand factor.

J. Thromb. Haemost. 6: 1789-1795, 2008.

2007

17. S.-Z. Luo, X. Mo, J. A. López, R. Li.

Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex.

J. Thromb. Haemost. 5: 2494-2502, 2007.

16. S.-Z. Luo, X. Mo, V. Afshar-Kharghan, S. Srinivasan, J. A. López, R. Li.

Glycoprotein Ibα forms disulfide bonds with 2 glycoprotein Ibβ subunits in the resting platelet.

Blood 109: 603-609, 2007.

(with commentary in Blood 109: 393-394)

2006

15. X. Mo, N. Lu, A. Padilla, J. A. López, R. Li.

The transmembrane domain of glycoprotein Ibβ is critical to efficient surface expression of glycoprotein Ib-IX complex in the plasma membrane.

J. Biol. Chem. 281: 23050-23059, 2006.

2005

14. Y. Peng, Z. Tao, L. Nolasco, S. Cal, C. Lopez-Otin, R. Li, J. F. Moake, J. A. López, J.-F. Dong

Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.

Blood 106: 4139-4145, 2005.

Postdoctoral Work

13. W. Li, D. G. Metcalf, R. Gorelik, R. Li, N. Mitra, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett

A push-pull mechanism for regulating integrin function.

Proc. Natl. Acad. Sci. 102: 1424-1429, 2005.

12. R. Li, R. Gorelik, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett

Dimerization of the transmembrane domain of integrin αIIb subunit in cell membranes.

J. Biol. Chem. 279: 26666-26673, 2004.

11. R. Li, J. S. Bennett, W. F. DeGrado

Structural basis for integrin αIIbβ3 clustering.

Biochem. Soc. Trans. 32: 412-415, 2004.

10. R. Li, N. Mitra, H. Gratkowski, G. Vilaire, R. Litvinov, C. Nagasami, J. W. Weisel, J. D. Lear, W. F. DeGrado, J. S. Bennett

Activation of integrin αIIbβ3 by modulation of transmembrane helix associations.

Science 300: 795-798, 2003.

(commentary in Science 300: 755-756)

9. R. Li, R. H. Hoess, J. S. Bennett, W. F. DeGrado

Use of a phage displayed protein scaffold for determining binding specificity to integrins.

Protein Eng. 16: 65-72, 2003.

8. R. Li, C. R. Babu, K. Valentine, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of integrin β3 subunit by NMR spectroscopy.

Biochemistry 41: 15618-15624, 2002.

5. R. Li, C. R. Babu, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado

Oligomerization of the integrin αIIbβ3: roles of the transmembrane and cytoplasmic domains.

Proc. Natl. Acad. Sci. 98: 12462-12467, 2001.

Graduate Work

7. R. Li, J. L. Battiste, C. Woodward

Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding.

Biochemistry 41: 2246-2253, 2002.

6. J. L. Battiste, R. Li, C. Woodward

A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility.

Biochemistry 41: 2237-2245, 2002.

4. K. Akasaka, H. Li, H. Yamada, R. Li, T. Thoresen, C. Woodward

Pressure response of protein backbone structure. Pressure-induced amide 15N-chemical shifts in BPTI.

Protein Sci. 8: 1946-1953, 1999.

3. R. Li, C. Woodward

The hydrogen exchange core and protein folding.

Protein Sci. 8: 1571-1590, 1999.

2. C. Woodward, R. Li

The slow-exchange core and protein folding.

Trends Biochem. Sci. 23: 379-381, 1998.

1. J. Ng, R. Li, K. Morgan, J. Simon.

Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein.

Mol. Cell. Biol. 17: 6663-6672, 1997.