Renhao Li Lab:Publications: Difference between revisions

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{{Renhao_Li_Lab}}


==2015==
 
42. W. Deng, R. Li
==2024==
97. Arce NA, Markham-Lee Z, Liang Q, Najmudin S, Legan ER, Dean G, Su AJ, Wilson MS, Sidonio RF, Lollar P, Emsley J, Li R
:Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module
:'''Blood''' [https://doi.org/10.1182/blood.2023022038 Online ahead of print] [https://pubmed.ncbi.nlm.nih.gov/38290109/ PMID 38290109]
 
 
95. Li R
:Platelet size matters
:'''Blood''' [https://ashpublications.org/blood/article/143/4/298/514620/Platelet-size-matters 143: 298-300, 2024] [https://pubmed.ncbi.nlm.nih.gov/38270943/ PMID 38270943]
 
 
94. Saccuzzo EG, Mebrat MD, Scelsi HF, Kim M, Ma MT, Su X, Hill SE, Rheaume E, Li R, Torres MP, Gumbart JC, Van Horn WD, Lieberman RL
:Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming β-propeller
:'''Nat. Commun.''' [https://www.nature.com/articles/s41467-023-44479-2 15: 155, 2024] [https://pubmed.ncbi.nlm.nih.gov/38168102/ PMID 38168102]
 
==2023==
93. Duan Y, Szlam F, Hu Y, Chen W, Li R, Ke Y, Sniecinski R, Salaita K
:Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand
: '''Nat. Biomed. Eng.''' [http://doi.org/10.1038/s41551-023-01114-1 7: 1404-1418, 2023] [https://pubmed.ncbi.nlm.nih.gov/37957275/ PMID 37957275]
 
 
92. Von Beck T, Navarette K, Arce NA, Gao M, Dale GA, Davis-Gardner ME, Floyd K, Hernandez LM, Mullick N, Vanderheiden A, Skountzou I, Kuchipudi S, Saravanan R, Li R, Skolnick J, Suthar MS, Jacob J
:A wild boar cathelicidin peptide derivative inhibits severe acute respiratory syndrome coronavirus-2 and its drifted variants
:'''Sci. Rep.''' [http://doi.org/10.1038/s41598-023-41850-7 13: 14650, 2023]  [https://pubmed.ncbi.nlm.nih.gov/37670110/ PMID 37670110]
 
 
91. Ma R, Rashid SA, Velusamy A, Deal BR, Chen W, Petrich B, Li R, Salaita K
:Molecular mechanocytometry using tension-activated cell tagging (TaCT)
:'''Nat. Methods''' [http://doi.org/10.1038/s41592-023-02030-7 20: 1666-1671, 2023] [https://pubmed.ncbi.nlm.nih.gov/37798479/ PMID 37798479]
 
 
90. Li R
:Another layer of complexity in ectodomain shedding of platelet GPIbα
:'''J. Thromb. Haemost.''' [http://doi.org/10.1016/j.jtha.2023.04.006 21: 2051-2053, 2023]  [https://pubmed.ncbi.nlm.nih.gov/37468175/ PMID 37468175]
 
 
89. Wang Y, Li R
:Specific O-glycans in the mechanosensory domain of glycoprotein Ibα are important for its stability and function
:'''Haematologica''' [https://haematologica.org/article/view/haematol.2022.281979 108(9): 2526-2530, 2023]  [https://www.ncbi.nlm.nih.gov/pubmed/?term=36779596 PMID 36779596]
 
 
86. Beck S, Oftering P, Li R, Hemmen K, Nagy M, Wang Y, Zarpellon A, Schuhmann MK, Stoll G, Ruggeri ZM, Heinze KG, Heemskerk JWM, Ruf W, Stegner D, Nieswandt B.
:Platelet glycoprotein V spatiotemporally controls fibrin formation
:'''Nat. Cardiovasc. Res.''' [https://www.nature.com/articles/s44161-023-00254-6 2:368-382, 2023][https://www.ncbi.nlm.nih.gov/pubmed/?term=37206993 PMID 37206993]
 
 
88. Legan ER, Liu Y, Arce NA, Parker ET, Lollar P, Zhang XF, Li R
:Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain
:'''Blood''' [https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2022017239/493944/Type-2B-von-Willebrand-disease-mutations?redirectedFrom=fulltext 141:1221-1232, 2023]  [https://www.ncbi.nlm.nih.gov/pubmed/?term=36580664 PMID 36580664]
:''with a [https://ashpublications.org/blood/article/141/10/1102/494787/2B-or-not-2B-art-thou-autoinhibitory Commentary] in Blood 141:1102-1103''
[[Image:RenhaoLiLab_088abstract.jpg|500px|picture]]
 
 
87. Huang W, Li R, Zhang J, Cheng Y, Ramakrishnan DP, Silverstein RL
:A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions
:'''Transl. Res.''' [https://www.translationalres.com/article/S1931-5244(22)00224-9/fulltext 254:68-76, 2023]  [https://www.ncbi.nlm.nih.gov/pubmed/?term=36377115 PMID 36377115]
 
==2022==
85. Li R
:Recent advances on GPIb-IX-V complex (editorial)
:'''Platelets''' [https://www.tandfonline.com/doi/full/10.1080/09537104.2022.2075146 33:809-810, 2022] [https://www.ncbi.nlm.nih.gov/pubmed/?term=35543611 PMID 35543611]
 
 
84. Arce NA, Liu Y, Chen W, Zhang XF, Li R
:Autoinhibitory module underlies species difference in shear activation of von Willebrand factor
:'''J. Thromb. Haemost.''' [https://onlinelibrary.wiley.com/doi/abs/10.1111/jth.15837 20:2686-2696, 2022] [https://www.ncbi.nlm.nih.gov/pubmed/?term=36031939 PMID 36031939]
 
 
83. Chen W, Wilson MS, Wang Y, Bergmeier W, Lanza F, Li R
:Fast clearance of platelets in a commonly used mouse model for GPIbα is impeded by an anti-GPIbβ antibody derivative
:'''J. Thromb. Haemost.''' [https://onlinelibrary.wiley.com/doi/10.1111/jth.15702 20:1451-1463, 2022] [https://www.ncbi.nlm.nih.gov/pubmed/?term=35305057 PMID 35305057]
 
 
 
82. Ito J, Baldwin WH, Cox C, Healey J, Parker E, Legan ER, Li R, Gill S, Batsuli G
:Removal of single-site N-linked glycans on factor VIII alters binding of domain-specific monoclonal antibodies
:'''J. Thromb. Haemost.''' [https://onlinelibrary.wiley.com/doi/epdf/10.1111/jth.15616 20:574-588, 2022] [https://www.ncbi.nlm.nih.gov/pubmed/?term=34863021 PMID 34863021]
 
 
 
81. Voos KM, Cao W, Arce NA, Legan ER, Wang Y, Shajahan A, Azadi P, Lollar P, Zhang XF, Li R
:Desialylation of O-glycans activates Von Willebrand factor by destabilizing its autoinhibitory module
:'''J. Thromb. Haemost.''' [https://onlinelibrary.wiley.com/doi/epdf/10.1111/jth.15528 20:196-207, 2022] [https://www.ncbi.nlm.nih.gov/pubmed/?term=34529349 PMID 34529349]
:''Made journal cover''
[[Image:RenhaoLiLab_082cover.png|300px|picture]]
 
==2021==
80. Blanchard A, Combs DJ, Brockman JM, Kellner AV, Glazier R, Su H, Bender RL, Bazrafshan A, Chen W, Quach ME, Li R, Mattheyses AL, Salaita K
:Turn-key mapping of cell receptor force orientation and magnitude using a commercial structured illumination microscope
:'''Nat. Commun.''' [https://www.nature.com/articles/s41467-021-24602-x 12: 4693, 2021] [https://www.ncbi.nlm.nih.gov/pubmed/?term=34344862 PMID 34344862]
 
 
79. Hu Y, Ma VPY, Ma R, Chen W, Duan Y, Glazier R, Petrich B, Li R, Salaita K
:DNA-based microparticle tension sensors (µTS) for measuring cell mechanics in non-planar geometries and for high-throughput quantification
:'''Angew. Chem. Int. Ed. Engl.''' [https://onlinelibrary.wiley.com/doi/10.1002/anie.202102206 60: 18044-18050, 2021][https://www.ncbi.nlm.nih.gov/pubmed/?term=33979471 PMID 33979471]
 
 
78. Arce NA, Cao W, Brown AK, Legan ER, Wilson MS, Xu E-R, Berndt MC, Emsley J, Zhang XF*, Li R*
:Activation of Von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
:'''Nat. Commun.''' [https://www.nature.com/articles/s41467-021-22634-x 12: 2360, 2021] [https://www.ncbi.nlm.nih.gov/pubmed/?term=33883551 PMID 33883551]
 
 
77. Quach ME, Chen W, Wang Y, Deckmyn H, Lanza F, Nieswandt B, Li R
:Differential regulation of the platelet GPIb-IX complex by anti-GPIbb antibodies
:'''J. Thromb. Haemost.''' [https://onlinelibrary.wiley.com/doi/abs/10.1111/jth.15359 19: 2044-2055, 2021] [https://www.ncbi.nlm.nih.gov/pubmed/?term=33915031 PMID 33915031]
 
 
73. Wang Y, Chen W, Zhang W, Lee-Sundlov MM, Casari C, Berndt MC, Lanza F, Bergmeier W, Hoffmeister KM, Zhang XF, Li R
:Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance
:'''Haematologica''' [http://www.haematologica.org/content/early/2020/01/21/haematol.2019.240440.long 106: 220-229, 2021] [https://www.ncbi.nlm.nih.gov/pubmed/?term=31974202 PMID 31974202]
 
==2016-2020==
76. Quach ME, Li R
:Structure-function of platelet glycoprotein Ib-IX
:'''J. Thromb. Haemost.''' [https://onlinelibrary.wiley.com/doi/abs/10.1111/jth.15035 18: 3131-3134, 2020] [https://www.ncbi.nlm.nih.gov/pubmed/?term=32735697 PMID 32735697]
 
 
75. Brockman JM, Su H, Blanchard AT, Duan Y, Meyer T, Quach ME, Glazier R, Bazrafshan A, Bender RL, Kellner AV, Ogasawara H, Ma R, Schueder F, Petrich BG, Jungmann R, Li R, Mattheyses AL, Ke Y, Salaita K
:Live-cell super-resolved PAINT imaging of pN cellular traction forces
:'''Nat. Methods''' [https://www.nature.com/articles/s41592-020-0929-2 17: 1018-1024, 2020] [https://www.ncbi.nlm.nih.gov/pubmed/?term=32929270 PMID 32929270]
 
 
74. Fiore M, De Thore C, Randrianaivo-Ranjatoelina H, Baas MJ, Jacquemont ML, Darcel F, Dreyfus M, Lavenu-Bombled C, Li R, Gachet C, Dupuis A, Lanza F
:High prevalence of the natural Asn89Asp mutation in the <i>GP1BB</i> gene associated with Bernard-Soulier syndrome in French patients from the genetic isolate of Reunion island
:'''Br. J. Haematol.''' [https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.16479 189: e67-e71, 2020] [https://www.ncbi.nlm.nih.gov/pubmed/?term=31997307 PMID 31997307]
 
 
70. Tao Yª, Gan Cª, Zhang X, Liu L, Zakas PM, Doering CB, Mo X*, Li R*
:Unaccompanied mechanosensory domain mediates low expression of glycoprotein Ibα: Implications for Bernard-Soulier syndrome
:'''J. Thromb. Haemost.''' 18: 510-517, 2020 [https://www.ncbi.nlm.nih.gov/pubmed/?term=31749281 PMID 31749281]
 
 
72. Legan ER, Li R
:Gone with the vane
:'''Arterioscler. Thromb. Vasc. Biol.''' 39: 1702-1704, 2019 [https://www.ncbi.nlm.nih.gov/pubmed/?term=31433699 PMID 31433699]
 
 
71. Arce NA, Li R
:The secret afterlife of platelets
:'''Haematologica''' 104: [http://www.haematologica.org/content/104/9/1699 1699-1701], 2019 [https://www.ncbi.nlm.nih.gov/pubmed/?term=31473608 PMID 31473608]
 
 
69. Legan ER, Li R
:FAM-tastic phospho-regulation of von Willebrand factor activity
:'''J. Thromb. Haemost.''' 17: 863-865, 2019. [https://www.ncbi.nlm.nih.gov/pubmed/?term=30985992 PMID 30985992]
 
 
68. Proulle V, Strassel C, Perrault C, Baas M-J, Moog S, Mangin P, Nurden P, Nurden A, Adam F, Bryckaert M, Kauskot A, Li R, Lanza F
:A novel missense mutation in a Leucine-rich repeat of GPIbα in a Bernard-Soulier variant reduces shear-dependent adherence on von Willebrand factor
:'''Br. J. Haematol.''' 186: [https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.16068 e184-e187], 2019 [https://www.ncbi.nlm.nih.gov/pubmed/?term=31257572 PMID 31257572]
 
 
67. Chen W, Voos KM, Josephson CD, Li R
:Short-acting anti-VWF aptamer improves the recovery, survival, and hemostatic functions of refrigerated platelets
:'''Arterioscler. Thromb. Vasc. Biol.''' 39: [https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.119.312439 2028-2037], 2019. [https://www.ncbi.nlm.nih.gov/pubmed/?term=31315441 PMID 31315441]
:''with a [https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313069 Commentary] in Arterioscler. Thromb. Vasc. Biol. 39: 1893-1895''
[[Image:RenhaoLiLab_067abstract.jpg|500px|picture]]
 
 
66. Quach ME, Syed AK, Li R
:A uniform shear assay for human platelet and cell surface receptors via cone-plate viscometry
:'''J. Vis. Exp.''' 148: [https://www.jove.com/video/59704 e59704], 2019. [https://www.ncbi.nlm.nih.gov/pubmed/?term=31233025 PMID 31233025]
 
 
65. Zhang XF*, Zhang W, Quach ME, Deng W, Li R*
:Force-regulated refolding of the mechanosensory domain in the platelet glycoprotein Ib-IX complex
:'''Biophys. J.''' 116: 1960-1969, 2019. [https://www.ncbi.nlm.nih.gov/pubmed/?term=31030883 PMID 31030883]
 
 
64. Li C, Voos KM, Pathak M, Hall G, McCrae KR, Dreveny I, Li R, Emsley J
:Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI
:'''J. Thromb. Haemost.''' 17: 759-770, 2019. [https://www.ncbi.nlm.nih.gov/pubmed/?term=30801944 PMID 30801944]
 
 
63. Qi Y, Chen W, Liang X, Xu K, Gu X, Wu F, Fan X, Ren S, Liu J, Zhang J, Li R, Liu J, Liang X
:Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting VWF-GPIbα interaction
:'''J. Hematol. Oncol.''' 11: 117, 2018. [http://www.ncbi.nlm.nih.gov/pubmed?term=30223883 PMID 30223883]
 
 
62. Baaten CC, Swieringa F, Misztal T, Mastenbroek TG, Feijge MA, Bock PE, Donners MM, Collins PW, Li R, van der Meijden PE, Heemskerk JW
:Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects
:'''Blood Adv.''' 2: 2320-2331, 2018. [http://www.ncbi.nlm.nih.gov/pubmed?term=30232085 PMID 30232085]
 
 
61. Deng W, Voos KM, Colucci JK, Legan ER, Ortlund EA, Lollar P, Li R
:Delimiting the autoinhibitory module of von Willebrand factor
:'''J. Thromb. Haemost.''' 16: 2097-2105, 2018. [http://www.ncbi.nlm.nih.gov/pubmed?term=30053340 PMID 30053340]
 
 
60. Wang B, Perez-Pathke A, Li R, Liang J
:A general method for predicting amino acid residues experiencing hydrogen exchange
:'''IEEE EMBS Int Conf Biomed Health Inform.''' 2018: 341-344. [http://www.ncbi.nlm.nih.gov/pubmed?term=29780972 PMID 29780972]
 
 
59. Deng W, Voos KM, Li R
:A new redox switch regulating von Willebrand factor activity
:'''J. Thromb. Haemost.''' 16: 1257-1258, 2018 [http://www.ncbi.nlm.nih.gov/pubmed?term=29846041 PMID 29846041]
 
 
58. Cook AA, Deng W, Ren J, Li R, Sondek J, Bergmeier W
:Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF, CalDAG-GEFI
:'''J. Biol. Chem.''' 293: 8521-8529, 2018 [http://www.ncbi.nlm.nih.gov/pubmed?term=29622678 PMID 29622678]
 
 
57. Quach ME, Chen W, Li R
:Mechanisms of platelet clearance and translation to improve platelet storage
:'''Blood''' 131: 1512-1521, 2018 [http://www.ncbi.nlm.nih.gov/pubmed?term=29475962 PMID 29475962]
 
 
56. Li R
:The Glycoprotein Ib-IX-V Complex
:'''Platelets''' (4th edition) Eds. Michelson AD, Cattaneo M, Frelinger L, Newman PJ. Elsevier/Academic Press
 
 
54. Quach ME, Dragovich MA, Chen W, Syed AK, Cao W, Liang X, Deng W, De Meyer SF, Zhu G, Peng J, Ni H, Bennett CM, Hou M, Ware J, Deckmyn H, Zhang XF, Li R
:Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets
:'''Blood''' 131: 787-796, 2018 [http://www.ncbi.nlm.nih.gov/pubmed?term=29203584 PMID 29203584]
:''with a commentary in Blood 131: 713-714'' [http://www.bloodjournal.org/content/131/7/713 Inside Blood Commentary]
[[Image:RenhaoLiLab_055model.jpg|600px|picture]]
 
 
55. Chen W, Druzak SA, Wang Y, Josephson CD, Hoffmeister KM, Ware J, Li R
:Refrigeration-induced binding of von Willebrand factor facilitates fast clearance of refrigerated platelets
:'''Arterioscler. Thromb. Vasc. Biol.''' 37: 2271-2279, 2017 [http://www.ncbi.nlm.nih.gov/pubmed?term=29097365 PMID 29097365]
 
 
53. Li R
:Twins actin' differently
:'''Blood''' 130: 1688-1689, 2017 [http://www.ncbi.nlm.nih.gov/pubmed?term=29025716 PMID 29025716]
 
 
52. Deng W, Wang Y, Druzak SA, Healey JF, Syed AK, Lollar P, Li R
:A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor
:'''J. Thromb. Haemost.''' 15: 1867-1877, 2017 [http://www.ncbi.nlm.nih.gov/pubmed?term=28692141 PMID 28692141]
 
 
51. Lavenu-Bombled C, Guitton C, Dupuis A, Baas MJ, Desconclois C, Dreyfus M, Li R, Caron C, Gachet C, Fressinaud E, Lanza F
:A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B "Malmö/New York" von Willebrand disease
:'''Thromb. Haemost.''' 116: 1070-1078, 2016. [http://www.ncbi.nlm.nih.gov/pubmed?term=27683759 PMID 27683759]
 
 
50. W. Deng, Y. Xu, W. Chen, D. S. Paul, A. K. Syed, M. A. Dragovich, X. Liang, P. Zakas, M. C. Berndt, J. Di Paola, J. Ware, F. Lanza, C. B. Doering, W. Bergmeier, X. F. Zhang, R. Li
:Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
:'''Nat. Commun.''' 7: 12863, 2016.  [http://www.ncbi.nlm.nih.gov/pubmed?term=27670775 PMID 27670775]
:[http://news.emory.edu/stories/2016/09/renhao_li_platelet_biomechanics/index.html Emory press release]
:[http://www.pedsresearch.org/news/platelet-biomechanics-sheds-light-on-coronary-disease CHOA Peds research news]
[[Image:RenhaoLiLab_050model.jpg|600px|picture]]
 
 
 
49. G. Batsuli, W. Deng, J. F. Healey, E. T. Parker, W. H. Baldwin, C. Cox, B. Nguyen, J. Kahle, C. Koenigs, R. Li, P. Lollar, S. L. Meeks
:High-affinity, non-inhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors
:'''Blood''' 128: 2055-2067, 2016 [http://www.ncbi.nlm.nih.gov/pubmed?term=27381905 PMID 27381905]
:''with a commentary in Blood 128: 2001-2002'' [http://www.bloodjournal.org/content/128/16/2001 Inside Blood Commentary]
 
 
48. W. Chenª, X. Liangª, A. K. Syed, P. Jessup, W. R. Church, J. Ware, C. D. Josephson, R. Li
:Inhibiting GPIbα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage
:'''Arterioscler. Thromb. Vasc. Biol.''' 36: 1821-1828, 2016. [http://www.ncbi.nlm.nih.gov/pubmed?term=27417583 PMID 27417583]
:''with an Editorial in ATVB 36: 1715-1716'' [http://atvb.ahajournals.org/content/36/9/1715.extract ATVB online]
[[Image:RenhaoLiLab_048editorial.jpg|300px|picture]]
 
 
47. Y. Taoª, X. Zhangª, X. Liang, J. Zang, X. Mo*, R. Li*
:Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody
:'''Sci. Rep.''' 6: 24789, 2016. [http://www.ncbi.nlm.nih.gov/pubmed?term=27102061 PMID 27102061]
 
 
46. R. Li, K. M. Hoffmeister, H. Falet
:Glycans and the platelet life cycle
:'''Platelets''' 27: 505-511, 2016. [http://www.ncbi.nlm.nih.gov/pubmed?term=27135356 PMID 27135356]
 
 
45. X. Liang, A. K. Syed, S. R. Russell, J. Ware, R. Li
:Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance
:'''J. Thromb. Haemost.''' 14: 381-386, 2016.  [http://www.ncbi.nlm.nih.gov/pubmed?term=26662889 PMID 26662889]
 
==2011-2015==
44. S.L. Spitalnik, et al. State of the Science in Transfusion Medicine Working Groups (R. Li listed as a part of working groups)
:2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.
:'''Transfusion''' 55: 2282-2290, 2015. [http://www.ncbi.nlm.nih.gov/pubmed?term=26260861 Pubmed]
 
 
43. R. Li
:Expanding the binding model of DITP
:'''Blood''' 126: 2080-2081, 2015. [http://www.ncbi.nlm.nih.gov/pubmed?term=26516217 Pubmed]
 
 
42. J. Ciciliano, Y. Sakurai, D. R. Myers, M. E. Fay, B. Hechler, S. L. Meeks, R. Li, J. B. Dixon, L. A. Lyon, C. Gachet, W. A. Lam
:Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach
:'''Blood''' 126: 817-824, 2015. [http://www.ncbi.nlm.nih.gov/pubmed?term=25931587 Pubmed]
 
 
41. W. Deng, R. Li
:Juxtamembrane contribution to transmembrane signaling
:Juxtamembrane contribution to transmembrane signaling
:'''Biopolymers''' in press
:'''Biopolymers (Pept. Sci.)''' 104: 317-322, 2015. [http://www.ncbi.nlm.nih.gov/pubmed?term=25846274 Pubmed]




Line 11: Line 304:
:'''Blood''' 125: 562-569, 2015. [http://www.ncbi.nlm.nih.gov/pubmed?term=25359992 Pubmed] or [http://www.bloodjournal.org/content/125/3/562.abstract Blood online]
:'''Blood''' 125: 562-569, 2015. [http://www.ncbi.nlm.nih.gov/pubmed?term=25359992 Pubmed] or [http://www.bloodjournal.org/content/125/3/562.abstract Blood online]
:''with commentary in Blood 125: 423-424'' [http://www.bloodjournal.org/content/125/3/423 Blood online]
:''with commentary in Blood 125: 423-424'' [http://www.bloodjournal.org/content/125/3/423 Blood online]
[[Image:RenhaoLiLab_040commentary.jpg|200px|picture]]


==2014==
39. W. Deng, S. Cho, P.-C. Su, B. W. Berger, R. Li
39. W. Deng, S. Cho, P.-C. Su, B. W. Berger, R. Li
:Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10
:Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10
Line 27: Line 321:
:'''J. Thromb. Haemost.''' 12: 82-89, 2014.  [http://www.ncbi.nlm.nih.gov/pubmed?term=24406065 Pubmed]
:'''J. Thromb. Haemost.''' 12: 82-89, 2014.  [http://www.ncbi.nlm.nih.gov/pubmed?term=24406065 Pubmed]


==2013==
 
36. A. M. Sevy, J. F. Healey, W. Deng, P. C. Spiegel, S. L. Meeks*, R. Li*
36. A. M. Sevy, J. F. Healey, W. Deng, P. C. Spiegel, S. L. Meeks*, R. Li*
:Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry.
:Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry.
Line 59: Line 353:
:'''J. Thromb. Haemost.''' 11: 605-614, 2013 [http://www.ncbi.nlm.nih.gov/pubmed?term=23336709 Pubmed]
:'''J. Thromb. Haemost.''' 11: 605-614, 2013 [http://www.ncbi.nlm.nih.gov/pubmed?term=23336709 Pubmed]


==2012==
 
30. X. Mo, L. Liu, J. A. Lopez, R. Li
30. X. Mo, L. Liu, J. A. Lopez, R. Li
:Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex.
:Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex.
Line 67: Line 361:
[[Image:RenhaoLiLab_030cover.jpg|200px|picture]]
[[Image:RenhaoLiLab_030cover.jpg|200px|picture]]


==2011==
 
29. R. Yan, X. Mo, A. M. Paredes, K. Dai, F. Lanza, M. A. Cruz, R. Li
29. R. Yan, X. Mo, A. M. Paredes, K. Dai, F. Lanza, M. A. Cruz, R. Li
:Reconstitution of platelet glycoprotein Ib-IX complex in phospholipid bilayer nanodiscs.
:Reconstitution of platelet glycoprotein Ib-IX complex in phospholipid bilayer nanodiscs.
Line 92: Line 386:
:Cysteine residues in CUB-1 domain are critical for ADAMTS13 secretion and stability.  
:Cysteine residues in CUB-1 domain are critical for ADAMTS13 secretion and stability.  
:'''Thromb. Haemost.''' 105: 21-30, 2011. [http://www.ncbi.nlm.nih.gov/pubmed?term=20886194 Pubmed]
:'''Thromb. Haemost.''' 105: 21-30, 2011. [http://www.ncbi.nlm.nih.gov/pubmed?term=20886194 Pubmed]


==Before 2010==
==Before 2010==
Line 148: Line 443:
:Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.   
:Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.   
:'''Blood''' 106: 4139-4145, 2005. [http://www.ncbi.nlm.nih.gov/pubmed?term=16141351 Pubmed]
:'''Blood''' 106: 4139-4145, 2005. [http://www.ncbi.nlm.nih.gov/pubmed?term=16141351 Pubmed]


==Postdoctoral Work==
==Postdoctoral Work==
13. W. Li, D. G. Metcalf, R. Gorelik, R. Li, N. Mitra, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett
13. W. Li, D. G. Metcalf, R. Gorelik, R. Li, N. Mitra, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett
:A push-pull mechanism for regulating integrin function.   
:A push-pull mechanism for regulating integrin function.   
:'''Proc. Natl. Acad. Sci.''' 102: 1424-1429, 2005.
:'''Proc. Natl. Acad. Sci.''' 102: 1424-1429, 2005. [http://www.ncbi.nlm.nih.gov/pubmed?term=15671157 Pubmed]




12. R. Li, R. Gorelik, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett
12. R. Li, R. Gorelik, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett
:Dimerization of the transmembrane domain of integrin αIIb subunit in cell membranes.   
:Dimerization of the transmembrane domain of integrin αIIb subunit in cell membranes.   
:'''J. Biol. Chem.''' 279: 26666-26673, 2004.
:'''J. Biol. Chem.''' 279: 26666-26673, 2004. [http://www.ncbi.nlm.nih.gov/pubmed?term=15067009 Pubmed]




11. R. Li, J. S. Bennett, W. F. DeGrado
11. R. Li, J. S. Bennett, W. F. DeGrado
:Structural basis for integrin αIIbβ3 clustering.   
:Structural basis for integrin αIIbβ3 clustering.   
:'''Biochem. Soc. Trans.''' 32: 412-415, 2004.
:'''Biochem. Soc. Trans.''' 32: 412-415, 2004. [http://www.ncbi.nlm.nih.gov/pubmed?term=15157149 Pubmed]




10. R. Li, N. Mitra, H. Gratkowski, G. Vilaire, R. Litvinov, C. Nagasami, J. W. Weisel, J. D. Lear, W. F. DeGrado, J. S. Bennett   
10. R. Li, N. Mitra, H. Gratkowski, G. Vilaire, R. Litvinov, C. Nagasami, J. W. Weisel, J. D. Lear, W. F. DeGrado, J. S. Bennett   
:Activation of integrin αIIbβ3 by modulation of transmembrane helix associations.   
:Activation of integrin αIIbβ3 by modulation of transmembrane helix associations.   
:'''Science''' 300: 795-798, 2003.
:'''Science''' 300: 795-798, 2003. [http://www.ncbi.nlm.nih.gov/pubmed?term=12730600 Pubmed]
:''(commentary in '''Science''' 300: 755-756)''
:''(commentary in '''Science''' 300: 755-756)''


Line 173: Line 469:
9. R. Li, R. H. Hoess, J. S. Bennett, W. F. DeGrado
9. R. Li, R. H. Hoess, J. S. Bennett, W. F. DeGrado
:Use of a phage displayed protein scaffold for determining binding specificity to integrins.   
:Use of a phage displayed protein scaffold for determining binding specificity to integrins.   
:'''Protein Eng.''' 16: 65-72, 2003.
:'''Protein Eng.''' 16: 65-72, 2003. [http://www.ncbi.nlm.nih.gov/pubmed?term=12646694 Pubmed]




8. R. Li, C. R. Babu, K. Valentine, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado
8. R. Li, C. R. Babu, K. Valentine, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado
:Characterization of the monomeric form of the transmembrane and cytoplasmic domains of integrin β3 subunit by NMR spectroscopy.  
:Characterization of the monomeric form of the transmembrane and cytoplasmic domains of integrin β3 subunit by NMR spectroscopy.  
:'''Biochemistry''' 41: 15618-15624, 2002.
:'''Biochemistry''' 41: 15618-15624, 2002. [http://www.ncbi.nlm.nih.gov/pubmed?term=12501190 Pubmed]




5. R. Li, C. R. Babu, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado
5. R. Li, C. R. Babu, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado
:Oligomerization of the integrin αIIbβ3: roles of the transmembrane and cytoplasmic domains.  
:Oligomerization of the integrin αIIbβ3: roles of the transmembrane and cytoplasmic domains.  
:'''Proc. Natl. Acad. Sci.''' 98: 12462-12467, 2001.
:'''Proc. Natl. Acad. Sci.''' 98: 12462-12467, 2001. [http://www.ncbi.nlm.nih.gov/pubmed?term=11606749 Pubmed]
 


==Graduate Work==
==Graduate Work==
7. R. Li, J. L. Battiste, C. Woodward
7. R. Li, J. L. Battiste, C. Woodward
:Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding.  
:Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding.  
:'''Biochemistry''' 41: 2246-2253, 2002.
:'''Biochemistry''' 41: 2246-2253, 2002. [http://www.ncbi.nlm.nih.gov/pubmed?term=11841216 Pubmed]




6.  J. L. Battiste, R. Li, C. Woodward
6.  J. L. Battiste, R. Li, C. Woodward
:A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility.  
:A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility.  
:'''Biochemistry''' 41: 2237-2245, 2002.
:'''Biochemistry''' 41: 2237-2245, 2002. [http://www.ncbi.nlm.nih.gov/pubmed?term=11841215 Pubmed]




4.  K. Akasaka, H. Li, H. Yamada, R. Li, T. Thoresen, C. Woodward
4.  K. Akasaka, H. Li, H. Yamada, R. Li, T. Thoresen, C. Woodward
:Pressure response of protein backbone structure. Pressure-induced amide 15N-chemical shifts in BPTI.   
:Pressure response of protein backbone structure. Pressure-induced amide 15N-chemical shifts in BPTI.   
:'''Protein Sci.''' 8: 1946-1953, 1999.
:'''Protein Sci.''' 8: 1946-1953, 1999. [http://www.ncbi.nlm.nih.gov/pubmed?term=10548039 Pubmed]




3. R. Li, C. Woodward
3. R. Li, C. Woodward
:The hydrogen exchange core and protein folding.  
:The hydrogen exchange core and protein folding.  
:'''Protein Sci.''' 8: 1571-1590, 1999.
:'''Protein Sci.''' 8: 1571-1590, 1999. [http://www.ncbi.nlm.nih.gov/pubmed?term=10452602 Pubmed]




2.  C. Woodward, R. Li
2.  C. Woodward, R. Li
:The slow-exchange core and protein folding.  
:The slow-exchange core and protein folding.  
:'''Trends Biochem. Sci.''' 23: 379-381, 1998.
:'''Trends Biochem. Sci.''' 23: 379-381, 1998. [http://www.ncbi.nlm.nih.gov/pubmed?term=9810224 Pubmed]




1.  J. Ng, R. Li, K. Morgan, J. Simon
1.  J. Ng, R. Li, K. Morgan, J. Simon
:Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein.  
:Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein.  
:'''Mol. Cell. Biol.''' 17: 6663-6672, 1997.
:'''Mol. Cell. Biol.''' 17: 6663-6672, 1997. [http://www.ncbi.nlm.nih.gov/pubmed?term=9343430 Pubmed]
 
 
Once upon a time ...
:1,2-Dichloroethane degradation pathway [http://eawag-bbd.ethz.ch/dce/dce_map.html map]
:Biocatalysis/Biodegradation Database




(ª, co-first author; *, co-corresponding author)
(ª, co-first author; *, co-corresponding author)

Latest revision as of 18:41, 30 January 2024

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2024

97. Arce NA, Markham-Lee Z, Liang Q, Najmudin S, Legan ER, Dean G, Su AJ, Wilson MS, Sidonio RF, Lollar P, Emsley J, Li R

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module
Blood Online ahead of print PMID 38290109


95. Li R

Platelet size matters
Blood 143: 298-300, 2024 PMID 38270943


94. Saccuzzo EG, Mebrat MD, Scelsi HF, Kim M, Ma MT, Su X, Hill SE, Rheaume E, Li R, Torres MP, Gumbart JC, Van Horn WD, Lieberman RL

Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming β-propeller
Nat. Commun. 15: 155, 2024 PMID 38168102

2023

93. Duan Y, Szlam F, Hu Y, Chen W, Li R, Ke Y, Sniecinski R, Salaita K

Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand
Nat. Biomed. Eng. 7: 1404-1418, 2023 PMID 37957275


92. Von Beck T, Navarette K, Arce NA, Gao M, Dale GA, Davis-Gardner ME, Floyd K, Hernandez LM, Mullick N, Vanderheiden A, Skountzou I, Kuchipudi S, Saravanan R, Li R, Skolnick J, Suthar MS, Jacob J

A wild boar cathelicidin peptide derivative inhibits severe acute respiratory syndrome coronavirus-2 and its drifted variants
Sci. Rep. 13: 14650, 2023 PMID 37670110


91. Ma R, Rashid SA, Velusamy A, Deal BR, Chen W, Petrich B, Li R, Salaita K

Molecular mechanocytometry using tension-activated cell tagging (TaCT)
Nat. Methods 20: 1666-1671, 2023 PMID 37798479


90. Li R

Another layer of complexity in ectodomain shedding of platelet GPIbα
J. Thromb. Haemost. 21: 2051-2053, 2023 PMID 37468175


89. Wang Y, Li R

Specific O-glycans in the mechanosensory domain of glycoprotein Ibα are important for its stability and function
Haematologica 108(9): 2526-2530, 2023 PMID 36779596


86. Beck S, Oftering P, Li R, Hemmen K, Nagy M, Wang Y, Zarpellon A, Schuhmann MK, Stoll G, Ruggeri ZM, Heinze KG, Heemskerk JWM, Ruf W, Stegner D, Nieswandt B.

Platelet glycoprotein V spatiotemporally controls fibrin formation
Nat. Cardiovasc. Res. 2:368-382, 2023PMID 37206993


88. Legan ER, Liu Y, Arce NA, Parker ET, Lollar P, Zhang XF, Li R

Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain
Blood 141:1221-1232, 2023 PMID 36580664
with a Commentary in Blood 141:1102-1103

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87. Huang W, Li R, Zhang J, Cheng Y, Ramakrishnan DP, Silverstein RL

A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions
Transl. Res. 254:68-76, 2023 PMID 36377115

2022

85. Li R

Recent advances on GPIb-IX-V complex (editorial)
Platelets 33:809-810, 2022 PMID 35543611


84. Arce NA, Liu Y, Chen W, Zhang XF, Li R

Autoinhibitory module underlies species difference in shear activation of von Willebrand factor
J. Thromb. Haemost. 20:2686-2696, 2022 PMID 36031939


83. Chen W, Wilson MS, Wang Y, Bergmeier W, Lanza F, Li R

Fast clearance of platelets in a commonly used mouse model for GPIbα is impeded by an anti-GPIbβ antibody derivative
J. Thromb. Haemost. 20:1451-1463, 2022 PMID 35305057


82. Ito J, Baldwin WH, Cox C, Healey J, Parker E, Legan ER, Li R, Gill S, Batsuli G

Removal of single-site N-linked glycans on factor VIII alters binding of domain-specific monoclonal antibodies
J. Thromb. Haemost. 20:574-588, 2022 PMID 34863021


81. Voos KM, Cao W, Arce NA, Legan ER, Wang Y, Shajahan A, Azadi P, Lollar P, Zhang XF, Li R

Desialylation of O-glycans activates Von Willebrand factor by destabilizing its autoinhibitory module
J. Thromb. Haemost. 20:196-207, 2022 PMID 34529349
Made journal cover

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2021

80. Blanchard A, Combs DJ, Brockman JM, Kellner AV, Glazier R, Su H, Bender RL, Bazrafshan A, Chen W, Quach ME, Li R, Mattheyses AL, Salaita K

Turn-key mapping of cell receptor force orientation and magnitude using a commercial structured illumination microscope
Nat. Commun. 12: 4693, 2021 PMID 34344862


79. Hu Y, Ma VPY, Ma R, Chen W, Duan Y, Glazier R, Petrich B, Li R, Salaita K

DNA-based microparticle tension sensors (µTS) for measuring cell mechanics in non-planar geometries and for high-throughput quantification
Angew. Chem. Int. Ed. Engl. 60: 18044-18050, 2021PMID 33979471


78. Arce NA, Cao W, Brown AK, Legan ER, Wilson MS, Xu E-R, Berndt MC, Emsley J, Zhang XF*, Li R*

Activation of Von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
Nat. Commun. 12: 2360, 2021 PMID 33883551


77. Quach ME, Chen W, Wang Y, Deckmyn H, Lanza F, Nieswandt B, Li R

Differential regulation of the platelet GPIb-IX complex by anti-GPIbb antibodies
J. Thromb. Haemost. 19: 2044-2055, 2021 PMID 33915031


73. Wang Y, Chen W, Zhang W, Lee-Sundlov MM, Casari C, Berndt MC, Lanza F, Bergmeier W, Hoffmeister KM, Zhang XF, Li R

Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance
Haematologica 106: 220-229, 2021 PMID 31974202

2016-2020

76. Quach ME, Li R

Structure-function of platelet glycoprotein Ib-IX
J. Thromb. Haemost. 18: 3131-3134, 2020 PMID 32735697


75. Brockman JM, Su H, Blanchard AT, Duan Y, Meyer T, Quach ME, Glazier R, Bazrafshan A, Bender RL, Kellner AV, Ogasawara H, Ma R, Schueder F, Petrich BG, Jungmann R, Li R, Mattheyses AL, Ke Y, Salaita K

Live-cell super-resolved PAINT imaging of pN cellular traction forces
Nat. Methods 17: 1018-1024, 2020 PMID 32929270


74. Fiore M, De Thore C, Randrianaivo-Ranjatoelina H, Baas MJ, Jacquemont ML, Darcel F, Dreyfus M, Lavenu-Bombled C, Li R, Gachet C, Dupuis A, Lanza F

High prevalence of the natural Asn89Asp mutation in the GP1BB gene associated with Bernard-Soulier syndrome in French patients from the genetic isolate of Reunion island
Br. J. Haematol. 189: e67-e71, 2020 PMID 31997307


70. Tao Yª, Gan Cª, Zhang X, Liu L, Zakas PM, Doering CB, Mo X*, Li R*

Unaccompanied mechanosensory domain mediates low expression of glycoprotein Ibα: Implications for Bernard-Soulier syndrome
J. Thromb. Haemost. 18: 510-517, 2020 PMID 31749281


72. Legan ER, Li R

Gone with the vane
Arterioscler. Thromb. Vasc. Biol. 39: 1702-1704, 2019 PMID 31433699


71. Arce NA, Li R

The secret afterlife of platelets
Haematologica 104: 1699-1701, 2019 PMID 31473608


69. Legan ER, Li R

FAM-tastic phospho-regulation of von Willebrand factor activity
J. Thromb. Haemost. 17: 863-865, 2019. PMID 30985992


68. Proulle V, Strassel C, Perrault C, Baas M-J, Moog S, Mangin P, Nurden P, Nurden A, Adam F, Bryckaert M, Kauskot A, Li R, Lanza F

A novel missense mutation in a Leucine-rich repeat of GPIbα in a Bernard-Soulier variant reduces shear-dependent adherence on von Willebrand factor
Br. J. Haematol. 186: e184-e187, 2019 PMID 31257572


67. Chen W, Voos KM, Josephson CD, Li R

Short-acting anti-VWF aptamer improves the recovery, survival, and hemostatic functions of refrigerated platelets
Arterioscler. Thromb. Vasc. Biol. 39: 2028-2037, 2019. PMID 31315441
with a Commentary in Arterioscler. Thromb. Vasc. Biol. 39: 1893-1895

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66. Quach ME, Syed AK, Li R

A uniform shear assay for human platelet and cell surface receptors via cone-plate viscometry
J. Vis. Exp. 148: e59704, 2019. PMID 31233025


65. Zhang XF*, Zhang W, Quach ME, Deng W, Li R*

Force-regulated refolding of the mechanosensory domain in the platelet glycoprotein Ib-IX complex
Biophys. J. 116: 1960-1969, 2019. PMID 31030883


64. Li C, Voos KM, Pathak M, Hall G, McCrae KR, Dreveny I, Li R, Emsley J

Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI
J. Thromb. Haemost. 17: 759-770, 2019. PMID 30801944


63. Qi Y, Chen W, Liang X, Xu K, Gu X, Wu F, Fan X, Ren S, Liu J, Zhang J, Li R, Liu J, Liang X

Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting VWF-GPIbα interaction
J. Hematol. Oncol. 11: 117, 2018. PMID 30223883


62. Baaten CC, Swieringa F, Misztal T, Mastenbroek TG, Feijge MA, Bock PE, Donners MM, Collins PW, Li R, van der Meijden PE, Heemskerk JW

Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects
Blood Adv. 2: 2320-2331, 2018. PMID 30232085


61. Deng W, Voos KM, Colucci JK, Legan ER, Ortlund EA, Lollar P, Li R

Delimiting the autoinhibitory module of von Willebrand factor
J. Thromb. Haemost. 16: 2097-2105, 2018. PMID 30053340


60. Wang B, Perez-Pathke A, Li R, Liang J

A general method for predicting amino acid residues experiencing hydrogen exchange
IEEE EMBS Int Conf Biomed Health Inform. 2018: 341-344. PMID 29780972


59. Deng W, Voos KM, Li R

A new redox switch regulating von Willebrand factor activity
J. Thromb. Haemost. 16: 1257-1258, 2018 PMID 29846041


58. Cook AA, Deng W, Ren J, Li R, Sondek J, Bergmeier W

Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF, CalDAG-GEFI
J. Biol. Chem. 293: 8521-8529, 2018 PMID 29622678


57. Quach ME, Chen W, Li R

Mechanisms of platelet clearance and translation to improve platelet storage
Blood 131: 1512-1521, 2018 PMID 29475962


56. Li R

The Glycoprotein Ib-IX-V Complex
Platelets (4th edition) Eds. Michelson AD, Cattaneo M, Frelinger L, Newman PJ. Elsevier/Academic Press


54. Quach ME, Dragovich MA, Chen W, Syed AK, Cao W, Liang X, Deng W, De Meyer SF, Zhu G, Peng J, Ni H, Bennett CM, Hou M, Ware J, Deckmyn H, Zhang XF, Li R

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets
Blood 131: 787-796, 2018 PMID 29203584
with a commentary in Blood 131: 713-714 Inside Blood Commentary

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55. Chen W, Druzak SA, Wang Y, Josephson CD, Hoffmeister KM, Ware J, Li R

Refrigeration-induced binding of von Willebrand factor facilitates fast clearance of refrigerated platelets
Arterioscler. Thromb. Vasc. Biol. 37: 2271-2279, 2017 PMID 29097365


53. Li R

Twins actin' differently
Blood 130: 1688-1689, 2017 PMID 29025716


52. Deng W, Wang Y, Druzak SA, Healey JF, Syed AK, Lollar P, Li R

A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor
J. Thromb. Haemost. 15: 1867-1877, 2017 PMID 28692141


51. Lavenu-Bombled C, Guitton C, Dupuis A, Baas MJ, Desconclois C, Dreyfus M, Li R, Caron C, Gachet C, Fressinaud E, Lanza F

A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B "Malmö/New York" von Willebrand disease
Thromb. Haemost. 116: 1070-1078, 2016. PMID 27683759


50. W. Deng, Y. Xu, W. Chen, D. S. Paul, A. K. Syed, M. A. Dragovich, X. Liang, P. Zakas, M. C. Berndt, J. Di Paola, J. Ware, F. Lanza, C. B. Doering, W. Bergmeier, X. F. Zhang, R. Li

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
Nat. Commun. 7: 12863, 2016. PMID 27670775
Emory press release
CHOA Peds research news

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49. G. Batsuli, W. Deng, J. F. Healey, E. T. Parker, W. H. Baldwin, C. Cox, B. Nguyen, J. Kahle, C. Koenigs, R. Li, P. Lollar, S. L. Meeks

High-affinity, non-inhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors
Blood 128: 2055-2067, 2016 PMID 27381905
with a commentary in Blood 128: 2001-2002 Inside Blood Commentary


48. W. Chenª, X. Liangª, A. K. Syed, P. Jessup, W. R. Church, J. Ware, C. D. Josephson, R. Li

Inhibiting GPIbα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage
Arterioscler. Thromb. Vasc. Biol. 36: 1821-1828, 2016. PMID 27417583
with an Editorial in ATVB 36: 1715-1716 ATVB online

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47. Y. Taoª, X. Zhangª, X. Liang, J. Zang, X. Mo*, R. Li*

Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody
Sci. Rep. 6: 24789, 2016. PMID 27102061


46. R. Li, K. M. Hoffmeister, H. Falet

Glycans and the platelet life cycle
Platelets 27: 505-511, 2016. PMID 27135356


45. X. Liang, A. K. Syed, S. R. Russell, J. Ware, R. Li

Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance
J. Thromb. Haemost. 14: 381-386, 2016. PMID 26662889

2011-2015

44. S.L. Spitalnik, et al. State of the Science in Transfusion Medicine Working Groups (R. Li listed as a part of working groups)

2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.
Transfusion 55: 2282-2290, 2015. Pubmed


43. R. Li

Expanding the binding model of DITP
Blood 126: 2080-2081, 2015. Pubmed


42. J. Ciciliano, Y. Sakurai, D. R. Myers, M. E. Fay, B. Hechler, S. L. Meeks, R. Li, J. B. Dixon, L. A. Lyon, C. Gachet, W. A. Lam

Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach
Blood 126: 817-824, 2015. Pubmed


41. W. Deng, R. Li

Juxtamembrane contribution to transmembrane signaling
Biopolymers (Pept. Sci.) 104: 317-322, 2015. Pubmed


40. W. Zhangª, W. Dengª, L. Zhou, Y. Xu, W. Yang, X. Liang, Y. Wang, J. D. Kulman, X. F. Zhang*, R. Li*

Identification of a juxtamembrane mechano-sensitive domain in the platelet mechanosensor glycoprotein Ib-IX-V complex
Blood 125: 562-569, 2015. Pubmed or Blood online
with commentary in Blood 125: 423-424 Blood online

picture


39. W. Deng, S. Cho, P.-C. Su, B. W. Berger, R. Li

Membrane-enabled dimerization of the intrinsically disordered cytoplasmic domain of ADAM10
Proc. Natl. Acad. Sci. (track II) 111: 15987-92, 2014. Pubmed


38. Y. Morioka, C. Casari, N. Wohner, S. Cho, S. Kurata, A. Kitano, O.D. Christophe, P.J. Lenting, R. Li, C.V. Denis, N. Prevost

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.
Blood 123: 3344-53, 2014. Pubmed


37. L. Zhou, W. Yang, R. Li

Analysis of inter-subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib-IX complex.
J. Thromb. Haemost. 12: 82-89, 2014. Pubmed


36. A. M. Sevy, J. F. Healey, W. Deng, P. C. Spiegel, S. L. Meeks*, R. Li*

Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry.
J. Thromb. Haemost. 11: 2128-2136, 2013 Pubmed
Made journal cover Gallery

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35. X. Liang, S. R. Russell, S. Estelle, L. H. Jones, S. Cho, M. L. Kahn, M. C. Berndt, S. T. Bunting, J. Ware, R. Li

Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site.
J. Thromb. Haemost. 11: 2155-2162, 2013 Pubmed


34. W. Deng, S. Cho, R. Li

FERM domain of moesin desorbs the basic-rich cytoplasmic domain of L-selectin from the anionic membrane surface.
J. Mol. Biol. 425: 3549-3562, 2013 Pubmed


33. P. Mou, Z. Zeng, Q. Li, X. Liu, X. Xin, K. M. Wannemacher, C. Ruan, R. Li, L. F. Brass, L. Zhu

Identification of a calmodulin-binding domain in Sema4D that regulates its exodomain shedding in platelets.
Blood 121: 4221-30, 2013 Pubmed


32. W. Deng, J. A. Putkey, R. Li

Calmodulin adopts an extended conformation when interacting with L-selectin in membranes.
PLoS ONE 8: e62861, 2013 Pubmed or PLoS ONE online


31. R. Li*, J. Emsley

The organizing principle of platelet glycoprotein Ib-IX-V complex.
J. Thromb. Haemost. 11: 605-614, 2013 Pubmed


30. X. Mo, L. Liu, J. A. Lopez, R. Li

Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex.
J. Thromb. Haemost. 10: 1875-1886, 2012. Pubmed
Made journal cover Gallery

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29. R. Yan, X. Mo, A. M. Paredes, K. Dai, F. Lanza, M. A. Cruz, R. Li

Reconstitution of platelet glycoprotein Ib-IX complex in phospholipid bilayer nanodiscs.
Biochemistry 50: 10598-10606, 2011. Pubmed


28. P. A. McEwanª, W. Yangª, K. H. Carrª, X. Mo, X. Zheng, R. Li*, J. Emsley*

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera.
Blood 118: 5292-5301, 2011. Pubmed or Blood online
with commentary in Blood 118: 5065-5066 Blood online


27. W. Deng, S. Srinivasan, X. Zheng, J. A. Putkey, R. Li

Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding.
J. Mol. Biol. 411: 220-233, 2011. Pubmed


26. S. Srinivasanª, W. Dengª, R. Li

L-selectin transmembrane and cytoplasmic domains are monomeric in membranes.
Biochim. Biophys. Acta 1808: 1709-1715, 2011. Pubmed


25. Z. Zhou, H.-C. Yeh, H. Jing, C. Wang, Z. Tao, H. Choi, K. Aboulfatova, R. Li, J.-F. Dong

Cysteine residues in CUB-1 domain are critical for ADAMTS13 secretion and stability.
Thromb. Haemost. 105: 21-30, 2011. Pubmed


Before 2010

24. X. Mo, N. X. Nguyen, F.-T. Mu, W. Yang, S.-Z. Luo, H. Fan, R. K. Andrews, M. C. Berndt, R. Li

Trans-membrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibα.
J. Biol. Chem. 285: 32096-32104, 2010. Pubmed


23. R. Li

A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia.
Blood 115: 914, 2010. Pubmed


22. X. Mo, N. X. Nguyen, P. A. McEwan, X. Zheng, J. A. López, J. Emsley, R. Li

Binding of platelet glycoprotein Ibβ through the convex surface of leucine-rich repeats domain of glycoprotein IX.
J. Thromb. Haemost. 7: 1533-1540, 2009. Pubmed


21. Z. Zhou, H. Jing, Z. Tao, H. Choi, K. Aboulfatova, J. Moake, R. Li, J.-F. Dong

Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13.
Thromb. Res. 124: 323-327, 2009. Pubmed


20. X. Mo, S.-Z. Luo, J. A. López, R. Li

Juxtamembrane basic residues in the glycoprotein Ibβ cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex.
FEBS Lett. 582: 3270-3274, 2008. Pubmed


19. S.-Z. Luo, R. Li

Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complex.
J. Mol. Biol. 382: 448-457, 2008. Pubmed


18. X. Mo, S.-Z. Luo, A. D. Munday, W. Sun, M. C. Berndt, J. A. López, J.-F. Dong, R. Li

The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence receptor binding to von Willebrand factor.
J. Thromb. Haemost. 6: 1789-1795, 2008. Pubmed


17. S.-Z. Luo, X. Mo, J. A. López, R. Li

Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex.
J. Thromb. Haemost. 5: 2494-2502, 2007. Pubmed


16. S.-Z. Luoª, X. Moª, V. Afshar-Kharghan, S. Srinivasan, J. A. López, R. Li

Glycoprotein Ibα forms disulfide bonds with 2 glycoprotein Ibβ subunits in the resting platelet.
Blood 109: 603-609, 2007. Pubmed
(with commentary in Blood 109: 393-394)


15. X. Mo, N. Lu, A. Padilla, J. A. López, R. Li

The transmembrane domain of glycoprotein Ibβ is critical to efficient surface expression of glycoprotein Ib-IX complex in the plasma membrane.
J. Biol. Chem. 281: 23050-23059, 2006. Pubmed


14. Z. Tao, Y. Peng, L. Nolasco, S. Cal, C. Lopez-Otin, R. Li, J. F. Moake, J. A. López, J.-F. Dong

Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.
Blood 106: 4139-4145, 2005. Pubmed


Postdoctoral Work

13. W. Li, D. G. Metcalf, R. Gorelik, R. Li, N. Mitra, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett

A push-pull mechanism for regulating integrin function.
Proc. Natl. Acad. Sci. 102: 1424-1429, 2005. Pubmed


12. R. Li, R. Gorelik, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett

Dimerization of the transmembrane domain of integrin αIIb subunit in cell membranes.
J. Biol. Chem. 279: 26666-26673, 2004. Pubmed


11. R. Li, J. S. Bennett, W. F. DeGrado

Structural basis for integrin αIIbβ3 clustering.
Biochem. Soc. Trans. 32: 412-415, 2004. Pubmed


10. R. Li, N. Mitra, H. Gratkowski, G. Vilaire, R. Litvinov, C. Nagasami, J. W. Weisel, J. D. Lear, W. F. DeGrado, J. S. Bennett

Activation of integrin αIIbβ3 by modulation of transmembrane helix associations.
Science 300: 795-798, 2003. Pubmed
(commentary in Science 300: 755-756)


9. R. Li, R. H. Hoess, J. S. Bennett, W. F. DeGrado

Use of a phage displayed protein scaffold for determining binding specificity to integrins.
Protein Eng. 16: 65-72, 2003. Pubmed


8. R. Li, C. R. Babu, K. Valentine, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of integrin β3 subunit by NMR spectroscopy.
Biochemistry 41: 15618-15624, 2002. Pubmed


5. R. Li, C. R. Babu, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado

Oligomerization of the integrin αIIbβ3: roles of the transmembrane and cytoplasmic domains.
Proc. Natl. Acad. Sci. 98: 12462-12467, 2001. Pubmed


Graduate Work

7. R. Li, J. L. Battiste, C. Woodward

Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding.
Biochemistry 41: 2246-2253, 2002. Pubmed


6. J. L. Battiste, R. Li, C. Woodward

A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility.
Biochemistry 41: 2237-2245, 2002. Pubmed


4. K. Akasaka, H. Li, H. Yamada, R. Li, T. Thoresen, C. Woodward

Pressure response of protein backbone structure. Pressure-induced amide 15N-chemical shifts in BPTI.
Protein Sci. 8: 1946-1953, 1999. Pubmed


3. R. Li, C. Woodward

The hydrogen exchange core and protein folding.
Protein Sci. 8: 1571-1590, 1999. Pubmed


2. C. Woodward, R. Li

The slow-exchange core and protein folding.
Trends Biochem. Sci. 23: 379-381, 1998. Pubmed


1. J. Ng, R. Li, K. Morgan, J. Simon

Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein.
Mol. Cell. Biol. 17: 6663-6672, 1997. Pubmed


Once upon a time ...

1,2-Dichloroethane degradation pathway map
Biocatalysis/Biodegradation Database


(ª, co-first author; *, co-corresponding author)

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