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<h3><font style="color:#F8B603;">research</font></h3>
[[Image:Arabidopsis_smiley-compressed.jpg‎|400px|left]][[Image:Wordle_03-13.png‎|350px|right]] <br>
'''HOW''' do organisms adapt to the environment and how do they react to different biotic and abiotic stimuli? <br>
 
major players in the conversion of such stimuli into cellular responses are hormones acting as signaling molecules.
 
our lab is primarily interested in understanding the genetics and molecular biology of
 
[http://en.wikipedia.org/wiki/Auxin auxin] and other [http://en.wikipedia.org/wiki/Plant_hormone plant hormone] responses in the tiny weed [http://en.wikipedia.org/wiki/Arabidopsis_thaliana arabidopsis thaliana] and related [http://en.wikipedia.org/wiki/Brassicaceae brassicaceae]. since several of these hormone-triggered signaling cascades are regulated by the [http://en.wikipedia.org/wiki/Proteasome ubiquitin-proteasome system] SCF-type E3 ubiquitin ligases and functional characterization of their selective f-box protein subunits are another focus of our research activities.<br>
 
we apply mostly [http://en.wikipedia.org/wiki/Genomics genomics] approaches, such as:
 
*forward [http://en.wikipedia.org/wiki/Genetic_screen genetic screens] and [http://en.wikipedia.org/wiki/Reverse_genetics reverse genetics]
 
*whole genome [http://en.wikipedia.org/wiki/Expression_profiling expression profiling]
 
*utilizing natural [http://en.wikipedia.org/wiki/Genetic_variation genetic variation] within the global arabidopsis gene pool
 
*[http://en.wikipedia.org/wiki/Quantitative_genetics quantitative genetics] → [http://en.wikipedia.org/wiki/Quantitative_trait_locus qtl] mapping
the quint lab is part of the [http://www.ipb-halle.de/en/research/molecular-signal-processing/ department of molecular signal processing] at the [http://www.ipb-halle.de/en/ leibniz institute of plant biochemistry] in halle (saale), germany. 5 keywords to describe our major [http://openwetware.org/wiki/Quint_Lab:Research research interests]: <br>
*evolutionary and [http://en.wikipedia.org/wiki/Population_genomics population genomics]
- [http://en.wikipedia.org/wiki/Auxin auxin]<br>
*[http://en.wikipedia.org/wiki/Comparative_genomics comparative genomics]<br>
- [http://en.wikipedia.org/wiki/Genetic_diversity natural variation]<br>
- [http://en.wikipedia.org/wiki/Evo-devo evo-devo]<br>
- [http://en.wikipedia.org/wiki/Genomics genomics]/[http://en.wikipedia.org/wiki/Transcriptomics transcriptomics]<br>
- [http://en.wikipedia.org/wiki/Quantitative_genetics quantitative genetics]
 
 
'''selected publications''':
 
[[Image:BioRxiv_logo.png|100px|left]] Ibañez C, Poeschl Y, Peterson T, Bellstädt J, Denk K, Gogol-Döring A, Quint M, Delker C ('''2015''') Developmental plasticity of Arabidopsis thaliana accessions across an ambient temperature range. [http://www.biorxiv.org/content/early/2015/03/30/017285 ''bioRxiv preprint''] ('''open access'''). <br>
 
 
[[Image:BioRxiv_logo.png|100px|left]] Raschke A, Ibañez C, Ullrich KK, Anwer MU, Becker S, Glöckner A, Trenner J, Denk K, Saal B, Sun X, Ni M, Davis SJ, Delker C, Quint M ('''2015''') Natural Variants of ELF3 Affect Thermomorphogenesis by Transcriptionally Modulating PIF4-Dependent Auxin Response Genes. [http://dx.doi.org/10.1101/015305 ''bioRxiv preprint''] ('''open access'''). <br>
 
 
[[Image:MBE_logo.png|100px|left]] Drost H-G, Gabel A, Grosse I, Quint M ('''2015''') Evidence for active maintenance of phylotranscriptomic hourglass patterns in animal and plant embryogenesis. [http://mbe.oxfordjournals.org/content/early/2015/03/05/molbev.msv012.full.pdf+html ''Molecular Biology and Evolution'' 32:1221-1231]. ('''open access''')<br>
 
 
[[Image:Cell_reports_logo3.png|100px|left]] Delker C, Sonntag L, Velikkakam James G, Janitza P, Ibañez C, Ziermann, H, Peterson T, Denk K, Mull S, Ziegler J, Davis SJ, Schneeberger K, Quint M ('''2014''') The DET1-COP1-HY5 pathway constitutes a multipurpose signaling module regulating plant photomorphogenesis and thermomorphogenesis. [http://www.cell.com/cell-reports/abstract/S2211-1247%2814%2901009-2# ''Cell Reports'' 9:1983-1989]. ('''open access''')<br>
Degrading new insights into temperature sensing in plants: [http://news.cell.com/cellreports/cell-reports/degrading-new-insights-into-temperature-sensing-in-plants-commentary-by-christine-queitsch Commentary by Christine Queitsch]
 
 
[[Image:logo_pone.png|100px|left]] Navarro-Quezada A, Schumann N, Quint M ('''2013''') Plant F-Box protein evolution is determined by lineage-specific timing of major gene family expansion waves. [http://dx.plos.org/10.1371/journal.pone.0068672 ''PloS ONE'' 8:e68672]. ('''open access''') <br>


we are located at the leibniz institute of plant biochemistry [http://www.ipb-halle.de/en/ (ipb)] in halle. our junior research group is part of a larger research network that deals with structures and mechanisms of biological information processing, the so-called [http://www.exzellenznetzwerk-biowissenschaften.uni-halle.de/component/option,com_frontpage/Itemid,1/ exzellenznetzwerk für biowissenschaften]. see our [http://www.ipb-halle.de/de/forschung/stress-und-entwicklungsbiologie/forschungsgruppen/auxin-signaltransduktion/ static website].
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===publications===
*M Quint, Barkawi LS, Fan K-T, Cohen JD, Gray WM ('''2009''') Arabidopsis IAR4 modulates auxin response by regulating auxin homeostasis. [http://www.ncbi.nlm.nih.gov/pubmed/19395411?ordinalpos=1&itool=Email.EmailReport.Pubmed_ReportSelector.Pubmed_RVDocSum Plant Phys 150:748-758]


*Zhang W, Ito H, Quint M, Huang H, Noël LD, Gray WM ('''2008''') Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex. [http://www.ncbi.nlm.nih.gov/pubmed/18550827?dopt=AbstractPlus PNAS 105:8470-8475]. <br>
[[Image:Logo_naturesmall.png|100px|left]] Quint M, Drost H-G, Gabel A, Ullrich KK, Boenn M, Grosse I ('''2012''') A transcriptomic hourglass in plant embryogenesis. [http://www.ncbi.nlm.nih.gov/pubmed/22951968 ''Nature'' 490:98-101]. <br>
[[Media:Nature_cover_10-04-2012.jpg|cover]]; [http://f1000.com/717957827?bd=1 Faculty of 1000 recommended]<br>


*C Delker, Raschke A, Quint M ('''2008''') Auxin dynamics: the dazzling complexity of a small molecule’s message. [http://www.ncbi.nlm.nih.gov/pubmed/18299888?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Planta 227:929-941]. <br>


*M Quint, Gray WM ('''2006''') Auxin signaling. [http://www.ncbi.nlm.nih.gov/pubmed/16877027?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Current Opinion in Plant Biology 9:448-453].<br>
[[Image:Logo_trends.png|100px|left]] Delker C, Quint M ('''2011''') Expression level polymorphisms: heritable traits shaping natural variation. [http://www.ncbi.nlm.nih.gov/pubmed/21700486 ''Trends in Plant Science'' 9:481-488].<br>


*M Quint, Ito H, Zhang, W, Gray WM ('''2005''') Characterization of a novel temperature-sensitive allele of the CUL1/AXR6 subunit of SCF ubiquitin-ligases. [http://www.ncbi.nlm.nih.gov/pubmed/16045473?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Plant Journal 43:371-383].<br>
*... [[Quint_Lab:Publications | see more ...]]<br>


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[[Image:Logo_plantphys.png‎|100px|left]] Schumann N, Navarro-Quezada AR, Ullrich K, Kuhl C, Quint M ('''2011''') Molecular Evolution and Selection Patterns of Plant F-box Proteins with C-terminal Kelch Repeats. [http://www.ncbi.nlm.nih.gov/pubmed/21119043 ''Plant Physiology'' 155:835-850]. ('''open access''')<br>


===teaching this semester===
[[Image:Logo_plant_cell.png|100px|left]] Delker C, Pöschl Y, Raschke A, Ullrich K, Ettingshausen S, Hauptmann V, Grosse I, Quint M ('''2010''') Natural variation of transcriptional auxin response networks in ''Arabidopsis thaliana''. [http://www.ncbi.nlm.nih.gov/pubmed/20622145 ''Plant Cell'' 22:2184-2200]. ('''open access''')<br>
*'''mittwochs''', '''15-17:00 uhr''', biologicum seminarraum gewächshaus:
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**[[Quint_Lab:Signal transduction seminar 09 | molekulare mechanismen der signaltransduktion]] ss2009 → [[Quint_Lab:Signaling seminar papers| '''unterlagen hier''']]<br>


*[[Quint_Lab:Teaching | previous semesters]]
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===contact===
email: mquint (at) ipb-halle (dot) de <br>
phone: +49-345-5582 1480<br>
[http://www.ipb-halle.de/en/ leibniz-institut für pflanzenbiochemie halle (saale)] →[[Quint_Lab:Contact| how to get there]]
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Revision as of 01:37, 24 April 2015

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the quint lab is part of the department of molecular signal processing at the leibniz institute of plant biochemistry in halle (saale), germany. 5 keywords to describe our major research interests:
- auxin
- natural variation
- evo-devo
- genomics/transcriptomics
- quantitative genetics


selected publications:

Ibañez C, Poeschl Y, Peterson T, Bellstädt J, Denk K, Gogol-Döring A, Quint M, Delker C (2015) Developmental plasticity of Arabidopsis thaliana accessions across an ambient temperature range. bioRxiv preprint (open access).


Raschke A, Ibañez C, Ullrich KK, Anwer MU, Becker S, Glöckner A, Trenner J, Denk K, Saal B, Sun X, Ni M, Davis SJ, Delker C, Quint M (2015) Natural Variants of ELF3 Affect Thermomorphogenesis by Transcriptionally Modulating PIF4-Dependent Auxin Response Genes. bioRxiv preprint (open access).


Drost H-G, Gabel A, Grosse I, Quint M (2015) Evidence for active maintenance of phylotranscriptomic hourglass patterns in animal and plant embryogenesis. Molecular Biology and Evolution 32:1221-1231. (open access)


Delker C, Sonntag L, Velikkakam James G, Janitza P, Ibañez C, Ziermann, H, Peterson T, Denk K, Mull S, Ziegler J, Davis SJ, Schneeberger K, Quint M (2014) The DET1-COP1-HY5 pathway constitutes a multipurpose signaling module regulating plant photomorphogenesis and thermomorphogenesis. Cell Reports 9:1983-1989. (open access)

Degrading new insights into temperature sensing in plants: Commentary by Christine Queitsch


Navarro-Quezada A, Schumann N, Quint M (2013) Plant F-Box protein evolution is determined by lineage-specific timing of major gene family expansion waves. PloS ONE 8:e68672. (open access)


Quint M, Drost H-G, Gabel A, Ullrich KK, Boenn M, Grosse I (2012) A transcriptomic hourglass in plant embryogenesis. Nature 490:98-101.

cover; Faculty of 1000 recommended


Delker C, Quint M (2011) Expression level polymorphisms: heritable traits shaping natural variation. Trends in Plant Science 9:481-488.


Schumann N, Navarro-Quezada AR, Ullrich K, Kuhl C, Quint M (2011) Molecular Evolution and Selection Patterns of Plant F-box Proteins with C-terminal Kelch Repeats. Plant Physiology 155:835-850. (open access)


Delker C, Pöschl Y, Raschke A, Ullrich K, Ettingshausen S, Hauptmann V, Grosse I, Quint M (2010) Natural variation of transcriptional auxin response networks in Arabidopsis thaliana. Plant Cell 22:2184-2200. (open access)


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