Quint Lab: Difference between revisions

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'''NEWS''': our lab has moved to a new location within the [http://www.ipb-halle.de/en/ IPB]. we are now located in the department of [http://www.ipb-halle.de/en/research/molecular-signal-processing/ molecular signal processing] in lab B104-106. marcel and carolin's new phone number is +49-345-5582-1230. the lab's phone number is -1221.
 
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[[Image:Arabidopsis_smiley-compressed.jpg‎|400px|left]][[Image:Wordle_03-13.png‎|350px|right]] <br>
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[[Image:Homepic.jpg‎|260px|right]]
 
<h3><font style="color:#F8B603;">research</font></h3>
 
'''HOW''' do organisms adapt to the environment and how do they react to different biotic and abiotic stimuli? <br>
 
major players in the conversion of such stimuli into cellular responses are hormones acting as signaling molecules.
 
our lab is primarily interested in understanding the genetics and molecular biology of
 
[http://en.wikipedia.org/wiki/Auxin auxin] and other [http://en.wikipedia.org/wiki/Plant_hormone plant hormone] responses in the tiny weed [http://en.wikipedia.org/wiki/Arabidopsis_thaliana arabidopsis thaliana] and related [http://en.wikipedia.org/wiki/Brassicaceae brassicaceae]. since several of these hormone-triggered signaling cascades are regulated by the [http://en.wikipedia.org/wiki/Proteasome ubiquitin-proteasome system] SCF-type E3 ubiquitin ligases and functional characterization of their selective f-box protein subunits are another focus of our research activities.<br>
the quint lab is part of the [http://www.ipb-halle.de/en/research/molecular-signal-processing/ department of molecular signal processing] at the [http://www.ipb-halle.de/en/ leibniz institute of plant biochemistry] in halle (saale), germany. 5 keywords to describe our major [http://openwetware.org/wiki/Quint_Lab:Research research interests]: <br>
we apply mostly [http://en.wikipedia.org/wiki/Genomics genomics] approaches, such as:
- [http://en.wikipedia.org/wiki/Auxin auxin]<br>
*forward [http://en.wikipedia.org/wiki/Genetic_screen genetic screens] and [http://en.wikipedia.org/wiki/Reverse_genetics reverse genetics]
- [http://en.wikipedia.org/wiki/Genetic_diversity natural variation]<br>
*whole genome [http://en.wikipedia.org/wiki/Expression_profiling expression profiling]
- [http://en.wikipedia.org/wiki/Evo-devo evo-devo]<br>
*utilizing natural [http://en.wikipedia.org/wiki/Genetic_variation genetic variation] within the global arabidopsis gene pool
- [http://en.wikipedia.org/wiki/Genomics genomics]/[http://en.wikipedia.org/wiki/Transcriptomics transcriptomics]<br>
*[http://en.wikipedia.org/wiki/Quantitative_genetics quantitative genetics] → [http://en.wikipedia.org/wiki/Quantitative_trait_locus qtl] mapping
- [http://en.wikipedia.org/wiki/Quantitative_genetics quantitative genetics]
*evolutionary and [http://en.wikipedia.org/wiki/Population_genomics population genomics]
 
*[http://en.wikipedia.org/wiki/Comparative_genomics comparative genomics]<br>


we are located at the leibniz institute of plant biochemistry [http://www.ipb-halle.de/en/ (ipb)] in halle. our junior research group is part of a larger research network that deals with structures and mechanisms of biological information processing, the so-called [http://www.exzellenznetzwerk-biowissenschaften.uni-halle.de/component/option,com_frontpage/Itemid,1/ exzellenznetzwerk für biowissenschaften]. see our [http://www.ipb-halle.de/de/forschung/stress-und-entwicklungsbiologie/forschungsgruppen/auxin-signaltransduktion/ static website].
'''selected publications''':
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===publications===
*C Delker, Pöschl Y, Raschke A, Ullrich K, Ettingshausen S, Hauptmann V, Grosse I, Quint M ('''2010''') Natural variation of transcriptional auxin response networks in Arabidopsis thaliana. '''Plant Cell''' 22:2184-2200 [http://www.ncbi.nlm.nih.gov/pubmed/20622145 Pubmed] [http://www.plantcell.org/cgi/reprint/tpc.110.073957v1?ijkey=cA9kBGzbeSu5aPE&keytype=ref pdf full text].


*A Hendrickson Culler, Quint M, Slovin JP, Cohen JD ('''2010''') Auxin chemical and molecular biology. In: [http://www.elsevier.com/wps/find/bookdescription.cws_home/719035/description#description Comprehensive Natural Products Chemistry – II; Volume 4: Chemical Ecology]. Ed. K Mori, Elsevier, UK. (''in press'')  
[[Image:Cell_reports_logo3.png|100px|left]] Delker C, Sonntag L, Velikkakam James G, Janitza P, Ibañez C, Ziermann, H, Peterson T, Denk K, Mull S, Ziegler J, Davis SJ, Schneeberger K, Quint M ('''2014''') The DET1-COP1-HY5 pathway constitutes a multipurpose signaling module regulating plant photomorphogenesis and thermomorphogenesis. [http://www.cell.com/cell-reports/abstract/S2211-1247%2814%2901009-2# ''Cell Reports'' 9:1983-1989]. ('''open access''')<br>
Degrading new insights into temperature sensing in plants: [http://news.cell.com/cellreports/cell-reports/degrading-new-insights-into-temperature-sensing-in-plants-commentary-by-christine-queitsch Commentary by Christine Queitsch]


*J Ludwig-Müller, Denk K, Cohen JD, Quint M ('''2010''') An inhibitor of tryptophan-dependent biosynthesis of indole-3-acetic acid alters seedling development in Arabidopsis. '''Journal of Plant Growth Regulation''' 29:242-248 [http://www.springerlink.com/content/h52m48m283g25777/?p=2fa0ab5fecfe47fdb442effb9736ddc2&pi=0 Abstract].


*M Quint, Barkawi LS, Fan K-T, Cohen JD, Gray WM ('''2009''') Arabidopsis IAR4 modulates auxin response by regulating auxin homeostasis. '''Plant Physiology''' 150:748-758 [http://www.ncbi.nlm.nih.gov/pubmed/19395411?ordinalpos=1&itool=Email.EmailReport.Pubmed_ReportSelector.Pubmed_RVDocSum  Pubmed].
[[Image:logo_pone.png|100px|left]] Navarro-Quezada A, Schumann N, Quint M ('''2013''') Plant F-Box protein evolution is determined by lineage-specific timing of major gene family expansion waves. [http://dx.plos.org/10.1371/journal.pone.0068672 ''PloS ONE'' 8:e68672]. ('''open access''') <br>


*W Zhang, Ito H, Quint M, Huang H, Noël LD, Gray WM ('''2008''') Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex. '''PNAS''' 105:8470-8475 [http://www.ncbi.nlm.nih.gov/pubmed/18550827?dopt=AbstractPlus Pubmed]. <br>


*C Delker, Raschke A, Quint M ('''2008''') Auxin dynamics: the dazzling complexity of a small molecule’s message. '''Planta''' 227:929-941 [http://www.ncbi.nlm.nih.gov/pubmed/18299888?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Pubmed]. <br>
[[Image:Logo_naturesmall.png|100px|left]] Quint M, Drost H-G, Gabel A, Ullrich KK, Boenn M, Grosse I ('''2012''') A transcriptomic hourglass in plant embryogenesis. [http://www.ncbi.nlm.nih.gov/pubmed/22951968 ''Nature'' 490:98-101]. <br>
[[Media:Nature_cover_10-04-2012.jpg|cover]]; [http://f1000.com/717957827?bd=1 Faculty of 1000 recommended]<br>


*M Quint, Gray WM ('''2006''') Auxin signaling. '''Current Opinion in Plant Biology''' 9:448-453 [http://www.ncbi.nlm.nih.gov/pubmed/16877027?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Pubmed].<br>


*M Quint, Ito H, Zhang, W, Gray WM ('''2005''') Characterization of a novel temperature-sensitive allele of the CUL1/AXR6 subunit of SCF ubiquitin-ligases. '''Plant Journal''' 43:371-383 [http://www.ncbi.nlm.nih.gov/pubmed/16045473?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Pubmed].<br>
[[Image:Logo_trends.png|100px|left]] Delker C, Quint M ('''2011''') Expression level polymorphisms: heritable traits shaping natural variation. [http://www.ncbi.nlm.nih.gov/pubmed/21700486 ''Trends in Plant Science'' 9:481-488].<br>
*... [[Quint_Lab:Publications | see more ...]]<br>


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===teaching this semester===
[[Image:Logo_plantphys.png‎|100px|left]] Schumann N, Navarro-Quezada AR, Ullrich K, Kuhl C, Quint M ('''2011''') Molecular Evolution and Selection Patterns of Plant F-box Proteins with C-terminal Kelch Repeats. [http://www.ncbi.nlm.nih.gov/pubmed/21119043 ''Plant Physiology'' 155:835-850]. ('''open access''')<br>
*'''dienstags''', '''15-17:00 uhr''', leibniz-institut für pflanzenbiochemie, phytotechnikum:
**seminar [[Quint_Lab:Signal transduction seminar 09 | molekulare mechanismen der signaltransduktion]] (signal transduction seminar)
*mqp genetik


*[[Quint_Lab:Teaching | previous semesters]]
[[Image:Logo_plant_cell.png|100px|left]] Delker C, Pöschl Y, Raschke A, Ullrich K, Ettingshausen S, Hauptmann V, Grosse I, Quint M ('''2010''') Natural variation of transcriptional auxin response networks in ''Arabidopsis thaliana''. [http://www.ncbi.nlm.nih.gov/pubmed/20622145 ''Plant Cell'' 22:2184-2200]. ('''open access''')<br>
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===contact===
email: mquint (at) ipb-halle (dot) de <br>
phone:(+49) 345 5582 1230<br>
[http://www.ipb-halle.de/en/ leibniz-institut für pflanzenbiochemie halle (saale)] →[[Quint_Lab:Contact| how to get there]]
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Revision as of 15:24, 19 December 2014

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the quint lab is part of the department of molecular signal processing at the leibniz institute of plant biochemistry in halle (saale), germany. 5 keywords to describe our major research interests:
- auxin
- natural variation
- evo-devo
- genomics/transcriptomics
- quantitative genetics


selected publications:

Delker C, Sonntag L, Velikkakam James G, Janitza P, Ibañez C, Ziermann, H, Peterson T, Denk K, Mull S, Ziegler J, Davis SJ, Schneeberger K, Quint M (2014) The DET1-COP1-HY5 pathway constitutes a multipurpose signaling module regulating plant photomorphogenesis and thermomorphogenesis. Cell Reports 9:1983-1989. (open access)

Degrading new insights into temperature sensing in plants: Commentary by Christine Queitsch


Navarro-Quezada A, Schumann N, Quint M (2013) Plant F-Box protein evolution is determined by lineage-specific timing of major gene family expansion waves. PloS ONE 8:e68672. (open access)


Quint M, Drost H-G, Gabel A, Ullrich KK, Boenn M, Grosse I (2012) A transcriptomic hourglass in plant embryogenesis. Nature 490:98-101.

cover; Faculty of 1000 recommended


Delker C, Quint M (2011) Expression level polymorphisms: heritable traits shaping natural variation. Trends in Plant Science 9:481-488.


Schumann N, Navarro-Quezada AR, Ullrich K, Kuhl C, Quint M (2011) Molecular Evolution and Selection Patterns of Plant F-box Proteins with C-terminal Kelch Repeats. Plant Physiology 155:835-850. (open access)


Delker C, Pöschl Y, Raschke A, Ullrich K, Ettingshausen S, Hauptmann V, Grosse I, Quint M (2010) Natural variation of transcriptional auxin response networks in Arabidopsis thaliana. Plant Cell 22:2184-2200. (open access)


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