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'''HOW''' do organisms adapt to the environment and how do they react to different biotic and abiotic stimuli? <br>
[[Image:Arabidopsis_smiley-compressed.jpg‎|400px|left]][[Image:Wordle_03-13.png‎|350px|right]] <br>
major players in the conversion of such stimuli into cellular responses are hormones acting as signaling molecules.
 
our lab is primarily interested in understanding the genetics and molecular biology of
 
[http://en.wikipedia.org/wiki/Auxin auxin] and other [http://en.wikipedia.org/wiki/Plant_hormone plant hormone] responses in the tiny weed [http://en.wikipedia.org/wiki/Arabidopsis_thaliana arabidopsis thaliana]. since several of these hormone-triggered signaling cascades are regulated by the [http://en.wikipedia.org/wiki/Proteasome ubiquitin-proteasome system] SCF-type E3 ubiquitin ligases and functional characterization of their selective f-box protein subunits are another focus of our research activities.<br>
 
we apply mostly genetic approaches, such as:  
 
*forward [http://en.wikipedia.org/wiki/Genetic_screen genetic screens]
 
*[http://en.wikipedia.org/wiki/Reverse_genetics reverse genetics]
 
*utilizing natural variation within the global arabidopsis gene pool
 
*quantitative genetics → [http://en.wikipedia.org/wiki/Quantitative_trait_locus qtl] mapping<br>
 
the quint lab is part of the [http://www.ipb-halle.de/en/research/molecular-signal-processing/ department of molecular signal processing] at the [http://www.ipb-halle.de/en/ leibniz institute of plant biochemistry] in halle (saale), germany. 5 keywords to describe our major [http://openwetware.org/wiki/Quint_Lab:Research research interests]: <br>
- [http://en.wikipedia.org/wiki/Auxin auxin]<br>
- [http://en.wikipedia.org/wiki/Genetic_diversity natural variation]<br>
- [http://en.wikipedia.org/wiki/Evo-devo evo-devo]<br>
- [http://en.wikipedia.org/wiki/Genomics genomics]/[http://en.wikipedia.org/wiki/Transcriptomics transcriptomics]<br>
- [http://en.wikipedia.org/wiki/Quantitative_genetics quantitative genetics] 
 
 
'''selected publications''':
 
[[Image:logo_pone.png|100px|left]] Navarro-Quezada A, Schumann N, Quint M ('''2013''') Plant F-Box protein evolution is determined by lineage-specific timing of major gene family expansion waves. [http://dx.plos.org/10.1371/journal.pone.0068672 PloS ONE 8: e68672] ('''open access'''). <br>
 
 
[[Image:Logo_naturesmall.png|100px|left]] Quint M, Drost H-G, Gabel A, Ullrich KK, Boenn M, Grosse I ('''2012''') A transcriptomic hourglass in plant embryogenesis. [http://www.ncbi.nlm.nih.gov/pubmed/22951968 Nature 490:98-101]; [[Media:Nature_cover_10-04-2012.jpg|cover]]; [http://f1000.com/717957827?bd=1 Faculty of 1000 recommended]<br>
 
 
[[Image:Logo_trends.png|100px|left]] Delker C, Quint M ('''2011''') Expression level polymorphisms: heritable traits shaping natural variation. [http://www.ncbi.nlm.nih.gov/pubmed/21700486 Trends in Plant Science 9:481-488].<br>
 
 
[[Image:Logo_plantphys.png‎|100px|left]] Schumann N, Navarro-Quezada AR, Ullrich K, Kuhl C, Quint M ('''2011''') Molecular Evolution and Selection Patterns of Plant F-box Proteins with C-terminal Kelch Repeats. [http://www.ncbi.nlm.nih.gov/pubmed/21119043 Plant Physiology 155:835-850] ('''open access''').<br>
 
[[Image:Logo_plant_cell.png|100px|left]] Delker C, Pöschl Y, Raschke A, Ullrich K, Ettingshausen S, Hauptmann V, Grosse I, Quint M ('''2010''') Natural variation of transcriptional auxin response networks in ''Arabidopsis thaliana''. [http://www.ncbi.nlm.nih.gov/pubmed/20622145 Plant Cell 22:2184-2200] ('''open access''').<br>
 
 
[[Image:Logo_plantphys.png‎|100px|left]] Quint M, Barkawi LS, Fan K-T, Cohen JD, Gray WM ('''2009''') Arabidopsis IAR4 modulates auxin response by regulating auxin homeostasis. [http://www.ncbi.nlm.nih.gov/pubmed/19395411?ordinalpos=1&itool=Email.EmailReport.Pubmed_ReportSelector.Pubmed_RVDocSum Plant Physiology 150:748-758] ('''open access''').<br>
 


we are located at the leibniz institute of plant biochemistry [http://www.ipb-halle.de/en/ (ipb)] in halle. our junior research group is part of a larger research network that deals with structures and mechanisms of biological information processing, the so-called [http://www.exzellenznetzwerk-biowissenschaften.uni-halle.de/component/option,com_frontpage/Itemid,1/ exzellenznetzwerk für biowissenschaften]. see our [http://www.ipb-halle.de/de/forschung/stress-und-entwicklungsbiologie/forschungsgruppen/auxin-signaltransduktion/ static website].
[[Image:Logo_pnas.jpg‎|100px|left]]  Zhang W, Ito H, Quint M, Huang H, Noël LD, Gray WM ('''2008''') Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex. [http://www.ncbi.nlm.nih.gov/pubmed/18550827?dopt=AbstractPlus Proc Natl Acad Sci U S A 105:8470-8475] ('''open access'''). <br>
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Revision as of 02:21, 31 October 2013

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the quint lab is part of the department of molecular signal processing at the leibniz institute of plant biochemistry in halle (saale), germany. 5 keywords to describe our major research interests:
- auxin
- natural variation
- evo-devo
- genomics/transcriptomics
- quantitative genetics


selected publications:

Navarro-Quezada A, Schumann N, Quint M (2013) Plant F-Box protein evolution is determined by lineage-specific timing of major gene family expansion waves. PloS ONE 8: e68672 (open access).


Quint M, Drost H-G, Gabel A, Ullrich KK, Boenn M, Grosse I (2012) A transcriptomic hourglass in plant embryogenesis. Nature 490:98-101; cover; Faculty of 1000 recommended


Delker C, Quint M (2011) Expression level polymorphisms: heritable traits shaping natural variation. Trends in Plant Science 9:481-488.


Schumann N, Navarro-Quezada AR, Ullrich K, Kuhl C, Quint M (2011) Molecular Evolution and Selection Patterns of Plant F-box Proteins with C-terminal Kelch Repeats. Plant Physiology 155:835-850 (open access).


Delker C, Pöschl Y, Raschke A, Ullrich K, Ettingshausen S, Hauptmann V, Grosse I, Quint M (2010) Natural variation of transcriptional auxin response networks in Arabidopsis thaliana. Plant Cell 22:2184-2200 (open access).


Quint M, Barkawi LS, Fan K-T, Cohen JD, Gray WM (2009) Arabidopsis IAR4 modulates auxin response by regulating auxin homeostasis. Plant Physiology 150:748-758 (open access).


Zhang W, Ito H, Quint M, Huang H, Noël LD, Gray WM (2008) Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex. Proc Natl Acad Sci U S A 105:8470-8475 (open access).


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