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Our laboratory focuses on fundamental understanding of the bio-nano interface and translating this to biomedical applications. Current efforts focus on the thermo-plasmonic fundamentals and its effects at the interface between biological systems and nanomaterials. Specifically, experimental techniques and methods will be developed to understand the effects of nanoparticle plasmonic heating on proteins and other biomolecules immediately surrounding the nanoparticle. This can lead to new enabling tools for fundamental research, and to applications in both diagnostic and therapeutic areas.
= NTBEL Lab Sources Scheduler =
[https://calendar.google.com/calendar/b/1/r?pli=1 Google Calendar for ps laser reservation]<br>


= Neuro Nanotechnologies and Brain Biotransport =


== Photosensitive nanovesicles ==
*Support: NSF <br>


== Fundamentals of Thermo-Plasmonics ==
*Relevant Publication:
1. Li, X., Che, Z., Price, T. and Qin Z. [http://onlinelibrary.wiley.com/doi/10.1002/adfm.201605778/full Ultrafast Near-Infrared Light-triggered Intracellular Uncaging to Probe Cell Signaling]. '''Advanced Functional Materials''', (2016)


2. Randrianalisoa, J., Li, X., Serre, M. and Qin Z., [https://doi.org/10.1002/adom.201700403 Understanding the Collective Optical Properties of Complex Plasmonic Vesicles]. '''Advanced Optical Materials''', (2017)


Plasmonic absorption of light by metal nanoparticles can generate significant amount of heat, leading to different thermophysical events as shown in Fig. 1. Although increasingly used by biomedical applications, the fundamentals of these thermophysical events are not well understood, especially with the nanoscale confinement and curvature. Our laboratory is interested in developing experimental and computational methods to improve the understanding of these fundamental thermophysical processes.  
3. Xiuying Li, Peiyuan Kang, Zhuo Chen, Sneha Lal, Li Zhang, Jeremiah J. Gassensmithbd and Zhenpeng Qin* [http://pubs.rsc.org/en/content/articlehtml/2018/cc/c7cc09613e Rock the nucleus: significantly enhanced nuclear membrane permeability and gene transfection by plasmonic nanobubble induced nanomechanical transduction], '''Chemical Communications'''. (2018)


[[Image:Fig1Thermophysical.png]]
4. Karim, M.R., Li, X., Kang, P., Randrianalisoa, J., Qin, Z.* and Qian, D.*, [https://onlinelibrary.wiley.com/doi/full/10.1002/adom.201800726 Ultrafast Pulsed Laser Induced Nanocrystal Transformation in Colloidal Plasmonic Vesicles], '''Advanced Optical Materials''', (2018)
Fig. 1 Schematics of thermophysical responses of thermo-plasmonic heating shown in a phase diagram. Figure is from Qin et al. CSR 2012


== Biomedical Applications of Thermo-Plasmonics ==
5. Hejian Xiong, Xiuying Li, Peiyuan Kang, John Perish, Frederik Neuhaus, Jonathan Ploski, Sven Kroener, Maria O. Ogunyankin, Jeong Eun Shin, Joseph A. Zasadzinski, Hui Wang, Paul Slesinger, Andreas Zumbuehl, Zhenpeng Qin*<br>
[https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201915296 Near-infrared Light Triggered-release in Deep Brain Regions Using Ultra-photosensitive Nanovesicles], '''Angewandte Chemie International Edition'''. (2020)


A compelling vision in nanomedicine is the use of self directed nanoparticles that can accumulate in areas of disease to perform designed functions, such as molecular delivery or destruction, endosomal release of genes or siRNA, and selective cell or tumor destruction with nano to macroscale spatiotemporal control and precision. These functions are increasingly achieved by gold nanoparticles (GNPs, such as sphere, shell or rod) that can be activated with a laser ‘‘switch’’. A defining aspect of this ‘‘switch’’ is GNP absorption of laser light and the ensuing heat generation and temperature change (i.e. thermo-plasmonics) that can be confined or propagated through multiple scales from the nanoparticle surface up through bulk biological cells and tissues. Our laboratory is interested in developing novel biomedical applications of thermo-plasmonics for fundamental research in cell biology, and for applications in disease diagnostics and therapeutics.
== Molecular Hyperthermia ==


[[Image:Fig2Biological.gif]]
*Support: UT Dallas <br>
Fig. 2 Overview of example biomedical applications of thermo-plasmonic heating of gold nanoparticles. Figure is from Qin et al. CSR 2012
 
*Relevant Publication:
 
1. Kang, P., Chen, Z., Nielsen, S.O., Hoyt, K., D’Arcy, S., Gassensmith, J. and Qin Z. [http://dx.doi.org/10.1002/smll.201700841 Molecular Hyperthermia: Spatiotemporal Protein Unfolding and Inactivation by Nanosecond Plasmonic Heating]. '''Small'''. 1700841. (2017)
 
2. Daipayan Sarkar, Peiyuan Kang, Steven O. Nielsen, Zhenpeng Qin* [https://pubs.acs.org/doi/full/10.1021/acsnano.9b00068 Non-Arrhenius Reaction-Diffusion Kinetics for Protein Inactivation over a Large Temperature Range], '''ACS Nano'''. (2019)
 
3. Peiyuan Kang, Xiaoqing Li, Yaning Liu, Stephanie I. Shiers, Hejian Xiong, Monica Giannotta, Elisabetta Dejana, Theodore John Price, Jaona Randrianalisoa, Steven O. Nielsen, and Zhenpeng Qin* [https://pubs.acs.org/doi/10.1021/acsnano.9b01993 Transient Photoinactivation of Cell Membrane Protein Activity without Genetic Modification by Molecular Hyperthermia], '''ACS Nano'''. (2019)
 
== Blood-Brain Barrier ==
 
*Support: CPRIT <br>
 
*Relevant Publication: coming
 
= Point-of-care diagnosis for infectious diseases  =
 
*Support: NIH<br>
 
*Relevant Publication:
 
1. Godakhindi, V.S. *, Kang, P. *, Serre, M. *, Revuru, N.A., Roner, M., Kahn, J., Randrianalisoa, J. and Qin Z.  [http://dx.doi.org/10.1021/acssensors.7b00482 Tuning the gold nanoparticle colorimetric assay by nanoparticle size, concentration, and size combinations for oligonucleotide detection]. ACS Sensors. 2017 (* co-first authors)
 
2.Haihang Ye, Yaning Liu, Li Zhan, Yilin Liu, Zhenpeng Qin* [https://www.thno.org/v10p4359.htm Signal amplification and quantification on lateral flow assays by laser excitation of plasmonic nanomaterials], '''Theranostics'''. (2020)
 
 
<br> © 2018 Zhenpeng Qin

Latest revision as of 13:41, 25 September 2020

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NTBEL Lab Sources Scheduler

Google Calendar for ps laser reservation

Neuro Nanotechnologies and Brain Biotransport

Photosensitive nanovesicles

  • Support: NSF
  • Relevant Publication:

1. Li, X., Che, Z., Price, T. and Qin Z. Ultrafast Near-Infrared Light-triggered Intracellular Uncaging to Probe Cell Signaling. Advanced Functional Materials, (2016)

2. Randrianalisoa, J., Li, X., Serre, M. and Qin Z., Understanding the Collective Optical Properties of Complex Plasmonic Vesicles. Advanced Optical Materials, (2017)

3. Xiuying Li, Peiyuan Kang, Zhuo Chen, Sneha Lal, Li Zhang, Jeremiah J. Gassensmithbd and Zhenpeng Qin* Rock the nucleus: significantly enhanced nuclear membrane permeability and gene transfection by plasmonic nanobubble induced nanomechanical transduction, Chemical Communications. (2018)

4. Karim, M.R., Li, X., Kang, P., Randrianalisoa, J., Qin, Z.* and Qian, D.*, Ultrafast Pulsed Laser Induced Nanocrystal Transformation in Colloidal Plasmonic Vesicles, Advanced Optical Materials, (2018)

5. Hejian Xiong, Xiuying Li, Peiyuan Kang, John Perish, Frederik Neuhaus, Jonathan Ploski, Sven Kroener, Maria O. Ogunyankin, Jeong Eun Shin, Joseph A. Zasadzinski, Hui Wang, Paul Slesinger, Andreas Zumbuehl, Zhenpeng Qin*
Near-infrared Light Triggered-release in Deep Brain Regions Using Ultra-photosensitive Nanovesicles, Angewandte Chemie International Edition. (2020)

Molecular Hyperthermia

  • Support: UT Dallas
  • Relevant Publication:

1. Kang, P., Chen, Z., Nielsen, S.O., Hoyt, K., D’Arcy, S., Gassensmith, J. and Qin Z. Molecular Hyperthermia: Spatiotemporal Protein Unfolding and Inactivation by Nanosecond Plasmonic Heating. Small. 1700841. (2017)

2. Daipayan Sarkar, Peiyuan Kang, Steven O. Nielsen, Zhenpeng Qin* Non-Arrhenius Reaction-Diffusion Kinetics for Protein Inactivation over a Large Temperature Range, ACS Nano. (2019)

3. Peiyuan Kang, Xiaoqing Li, Yaning Liu, Stephanie I. Shiers, Hejian Xiong, Monica Giannotta, Elisabetta Dejana, Theodore John Price, Jaona Randrianalisoa, Steven O. Nielsen, and Zhenpeng Qin* Transient Photoinactivation of Cell Membrane Protein Activity without Genetic Modification by Molecular Hyperthermia, ACS Nano. (2019)

Blood-Brain Barrier

  • Support: CPRIT
  • Relevant Publication: coming

Point-of-care diagnosis for infectious diseases

  • Support: NIH
  • Relevant Publication:

1. Godakhindi, V.S. *, Kang, P. *, Serre, M. *, Revuru, N.A., Roner, M., Kahn, J., Randrianalisoa, J. and Qin Z. Tuning the gold nanoparticle colorimetric assay by nanoparticle size, concentration, and size combinations for oligonucleotide detection. ACS Sensors. 2017 (* co-first authors)

2.Haihang Ye, Yaning Liu, Li Zhan, Yilin Liu, Zhenpeng Qin* Signal amplification and quantification on lateral flow assays by laser excitation of plasmonic nanomaterials, Theranostics. (2020)



© 2018 Zhenpeng Qin

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