Qianben Wang Laboratory: Difference between revisions

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<center><font face="lucida fax" style= "color:Yellow" size="+10">'''Qianben Wang Laboratory'''</font>
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[[Wang | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Wang:Research | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<center><font face="lucida fax" style= "color:Yellow" size="+2">'''Laboratory of Cancer Epigenomics'''</font></center>
[[Wang:Publications | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Publications''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Wang:Lab Members | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Lab Members''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<center><font face="lucida fax" style= "color:Yellow" size="+1">'''Department of Cancer Biology and Genetics, The Ohio State University'''</font>
[[Wang:Contact | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Contact''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Wang:News | <font face="lucida fax" style="color:#ffffff" size="+1"> '''News''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Research | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Publications | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Publications''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Lab Members | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Lab Members''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Contact | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Contact''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:News | <font face="lucida fax" style="color:#ffffff" size="+1"> '''News''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang:Gallery | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Gallery''' </font>]]  
[[Wang:Gallery | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Gallery''' </font>]]  
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<font face="lucia fax" color= "crimson" size="+1"> '''Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, <br> College of Medicine, The Ohio State University'''</font>
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<div style="text-align:left" font face="lucia fax">'''The schematic diagram of androgen receptor binding element (ARBE)-directed AR transcriptional regulation. Upper panel shows that agonist-bound AR (red) recognizes an agonist-ARBE in an agonist-specific manner, whereas the bottom panel indicates that antagonist-bound AR (blue) binds to an antagonist-ARBE in an antagonist-dependent manner. The binding of AR to two distinctly different motifs leads to distinct transcriptional outcomes in prostate cancer. The crystal structures of the DNA binding domain (DBD), dihydrotestosterone-ligand binding domain (DHT-LBD) and bicalutamide-LBD are modified from 1R4I, 1T7T and 1Z95, respectively.
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<font face="lucia fax">'''Our laboratory focuses on studying the role of Androgen Receptor in prostate cancer.'''</font>
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Revision as of 09:01, 1 July 2016

Qianben Wang Laboratory


Laboratory of Cancer Epigenomics


Department of Cancer Biology and Genetics, The Ohio State University


Home              Research              Publications              Lab Members              Contact              News              Gallery

The schematic diagram of androgen receptor binding element (ARBE)-directed AR transcriptional regulation. Upper panel shows that agonist-bound AR (red) recognizes an agonist-ARBE in an agonist-specific manner, whereas the bottom panel indicates that antagonist-bound AR (blue) binds to an antagonist-ARBE in an antagonist-dependent manner. The binding of AR to two distinctly different motifs leads to distinct transcriptional outcomes in prostate cancer. The crystal structures of the DNA binding domain (DBD), dihydrotestosterone-ligand binding domain (DHT-LBD) and bicalutamide-LBD are modified from 1R4I, 1T7T and 1Z95, respectively.
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