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| ''Back to [[Plastic Surgery Research Manchester - Staff and Students]]''
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| ==Dr Yusur Al-Nuaimi==
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| [[Image:yusur.jpg|100px|right|]]
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| Yusur completed her undergraduate studies at the University of Manchester when she obtained a BSc (2004) and MB ChB (2005). Yusur completed several research projects whilst a medical student. She presented at the British Association of Plastic, Reconstructive and Aesthetic Surgery’s Annual meeting and also published this work. Currently, she is working as a medical doctor in Hope Hospital, Manchester. She has been continuing involvement in research and was successfully awarded the EPSRC doctoral training centre scholarship which will be commencing in September 2007. At this time, she will commence her PhD concerned with keloid disease.
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| ==Mr Husam Bella==
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| [[Image:sam.jpg|100px|right|]]
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| MBBS MRCS
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| Background: Aesthetic Research Fellow, The healing foundation
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| Previous postgraduate work / experiences: I studied medicine in Sind Medical College and Jinnah Postgraduate Medical Centre (JPMC) in Karachi, Pakistan. I then proceeded to complete my medical internship in AlKhobar, Saudi Arabia at the King Fahad University Hospital. Following that I was a resident in General and Plastic Surgery at the tertiary referral centre of the eastern province of Saudi Arabia; Dammam Central Hospital. In my pursuit of a career in Plastic Surgery, I came to the UK in 2001 where I completed my Basic Surgical Training (BST) in the Northwest of England and worked at the departments of Plastic & Reconstructive Surgery at Booth Hall Children’s Hospital, Wythenshawe Hospital of the University in Manchester; and the Southwest of England at Frenchay Hospital in Bristol.
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| I am currently doing a PhD under the supervision of Dr Bayat. My project is aimed at identifying susceptibility genes to Keloid scarring. In October 2006, I was awarded the Aesthetic Research Fellowship by the Healing Foundation at the Royal College of Surgeons of England. The fellowship has enabled me to pursue fulfil my ambition in doing a higher degree and in this important and worthwhile subject area.
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| This is an international study looking at keloid families in Africa where keloid disease is endemic. Pedigrees will be established with a view to determine the heritability of keloid disease. Genetic samples from these patients will be analysed in Manchester at the Centre for Integrated Genomic Medical Research (CIGMR) and the Manchester Interdisciplinary Biocentre.
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| ==Mr Jean Philipe Frimat==
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| [[Image:jpfrimat.jpg|100px|right|]]
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| ==Mr Farzad Javad== | | ==Mr Farzad Javad== |
| [[Image:faz.jpg|100px|right|]] | | [[Image:faz.jpg|100px|right|]] |
| BSc, MSc
| | I finished my BSc in Immunology at King’s Collage London and started my MSc in Immunogenetics in Manchester. As part of my MSc, I was supervised by Dr Bayat and Dr Day for period of five months and I have been lucky to continue this for my PhD. My research in keloid scars involves gene expression, and cell cycle regulation. |
| Undergraduate University: King’s Collage London
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| Previous postgraduate work / experiences: I finished my BSc in Immunology at King’s Collage London and started my MSc in Immunogenetics in Manchester. As part of my MSc, I was supervised by Dr Bayat and Dr Day for period of five months and I have been lucky to continue this for my PhD. My research in keloid scars involves gene expression, and cell cycle regulation.
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| ==Miss Katherine Lau==
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| [[Image:klau.jpg|100px|right|]]
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| Qualification and research experience:
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| Katherine joined CIGMR in 2006 as a honorary research staff member. She obtained her MSc (2005) and her BSc Hons.(2004) from the University of Manchester and the University of Edinburgh respectively.
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| She has carried out research in various areas, including
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| -genetic ancestry (Y-SNPs and Y-microsatellites)
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| -lipid profiles of ancient Egyptian remains by GC-MS
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| -amoeba-flagellate differentiation
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| Research interests:
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| Katherine is interested in cell-cell interaction and how adult stem cells take part in wound healing and hopes to gain understanding in scarring disorders from the research. She is soon to start her PhD project at the Institute of Analytical Sciences in Dortmund, Germany.
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| ==Miss Lindsey Maccoux==
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| Originally from Wisconsin, USA where I obtained a BSc in Biology and Chemistry from 2000-2004. In 2005, I moved to England and studied at the University of Manchester on the Immunology and Immunogenetics master’s programme. As part of my MSc research, identified new reference genes for genetic expression analysis. Following the completion of my MSc in the fall of 2006, I began my PhD research at the Institute for Analytical Sciences (ISAS) in Dortmund, Germany under the supervision of Prof. Philip J. Day. My research is focused on quantitative analysis of nucleic acids in single cells. Currently, RT-qPCR is used to measure the average gene expression of a particular sample as a whole. This study will utilise new technology to develop an innovative way of measuring gene expression at the single cell level. A variety of novel techniques will be utilized to carry out studies, including quantitative-PCR.
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| [[Lindsey Maccoux - Publications|Lindsey Maccoux - Publications]]
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| [[Lindsey Maccoux - Presentations|Lindsey Maccoux - Presentations]]
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| ==Miss Melissa Mariani==
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| [[Image:melmariani.jpg|100px|right|]]
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| MSc
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| Master’s Thesis- March- August 2006, ‘Host- Parasite Interactions: The Trichiuris muris mouse model’
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| BSc Thesis- Jan- March 2005, ‘The Production of Monoclonal Antibodies To Mouse Anti-Müllerian Hormone’
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| Originally from United States, I carried out my Immunology and Immunogenetics MSc research under Dr. Kathryn J. Else at University of Manchester which began in the fall of 2005.
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| Following the completion of my MSc in the fall of 2006, I began PhD research at the Institute for Analytical Sciences (ISAS) in Dortmund, Germany and the Manchester Interdisciplinary Bioncentre at the University of Manchester under the supervision of Prof. Dr. Philip J. Day and Dr. Ardeshir Bayat. While at ISAS, my research is focused on the analysis of heterogeneous keloid tissues. Despite being of heterogeneous lineage, gene expression has been found to vary significantly resulting in a variety of inconsistent expression levels. As a result, the genetic variances between individual keloid and non-keloid derived cells will be investigated. This study will be carried out through the utilization of a variety of techniques, including quantitative- PCR.
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| ==Miss Samrina Rehman==
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| [[Image:samrina.jpg|100px|right|]]
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| MSc(2005) and MChem (2004) in Cheminformatics and Chemistry with Medicinal Chemistry from The University of Manchester.
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| Previous postgraduate work / experiences: Industrial work experiences include Inpharmatica Ltd (a drug discovery company) and Advanced Interconnection Technology (manufacturer of interconnection products).• Knowledge of commercial computational chemistry software and experience in the application of computational chemistry tools for database design, creation and analysis for drug discovery pipeline.
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| • Significant experience in working with Inpharmatica’s proprietary databases (StARLITe™ & Drugstore ™) and other commercial databases.
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| • Contributed to the development of various databases while working with Inpharmatica’s proprietary chemogenomics approach to drug discovery. Acknowledged work in ‘Nature Reviews, Vol 5, 2006’.
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| • Effective team member with good communication skills and enjoy learning new technologies.
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| Current Rotation project:
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| “Systems biology in clinical applications: Integrative ‘omics for patient to study Dupuytren's Disease.”
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| Systems biology approaches aim to provide a holistic and systems-level view of biological processes using computational tools and high-throughput technologies. It has emerged as an integrative approach that investigates inter and intra-cellular networks through mathematical modelling and simulation with the application of quantitative and mechanistic modelling to provide studies of genetic networks, signal transduction pathways and metabolic networks.
| | Co-supervisor: Dr Ardeshir Bayat. Co-supervisor: Dr Philip Day [http://www.mib.ac.uk. Manchester Interdisciplinary Biocentre] |
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| Dupuytren’s disease (DD) is a nodular palmar fibromatosis which causes progressive & permanent contracture of the digits. Current research on DD at CIGMR and MIB involves studies of tissue samples from patients with DD and integration of the datasets from genomics (SNPs), transcriptomics and proteomics collected from suitable test subjects and matched controls. Detailed quantitative phenotyping and correlation with microarray results as well as high-throughput genotyping has provided us with the datasets to implement systems biology approaches in fibrosis research.
| | [[Mr Farzad Javad - Publications]] |
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| Aims:
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| - Develop a systems biology approach to understand tissue fibrosis using the datasets integratively and generate a global model of nodular palmar fibromatosis (DD). | |
| - A review of current computational systems biology, bioinformatics and microarray tools available for data integration and management to compare and contrast the technological advances.
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