Phys 14. 장하나(Hana Jang)

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2015. 01. 29. Thur

Next paper

mk - http://bric.postech.ac.kr/myboard/view_report.php?Board=report&id=2288&type=1&filename=pdf_0002288.pdf

2015. 01. 27. Tue

Paper

Synthetic Lipid Membrane Channels Formed by Designed DNA Nanostructures

(Martin Langecker,1* Vera Arnaut,1* Thomas G. Martin,2* Jonathan List,1 Stephan Renner,1 Michael Mayer,3 Hendrik Dietz,2† Friedrich C. Simmel1†)

• Synthetic DNA membrane channels

1. nanometer-scale transmembrane channels in lipid bilayers by means of self-assembled DNA-based nanostructures
2. a stem that penetrated and spanned a lipidmembrane
3. a barrel-shaped cap that adhered to the membrane, in part via 26 cholesterol moieties

• Red denotes transmembrane stem; orange strands with orange ellipsoids indicate cholesterol-modified oligonucleotides that hybridize to single-stranded DNA adaptor strands.

DNA로 만든 Lipid Membrane Channels

막에 DNA 구조를 고정시킴 - 콜레스테롤 분자를 사용함

2015. 01. 20. Tue

paper

Folding DNA into Twisted and Curved Nanoscale Shapes

(Hendrik Dietz,1,2* Shawn M. Douglas,1,2,3 William M. Shih1,2,3†)

• Design principles

1. Every 7 base pairs (bp), the helical path of a strand rotates by 240° - a B-form–DNA
2. deletion of a base pair - a left-handed torque and a pull on its neighbors
3. insertion of a base pair - a right-handed torque and a push on its neighbors

• the pattern of insertions and deletions installed to induce bending.

DNA structure folding

canDNAno에서 skip base, loop 기능을 사용하면 휘어진 구조체를 디자인 할 수 있다.
-> 그 개수에 따라 휘는 각도가 달라짐