Pharmaceutics@SNU: Difference between revisions

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# Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8. doi: 10.1073/pnas. (PMID: 24961373) (5/26/15, 홍은진)
# Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8. doi: 10.1073/pnas. (PMID: 24961373) (5/26/15, 홍은진)
# Zamuner, S., Rabiner, E. A., Fernandes, S. A., Bani, M., Gunn, R. N., Gomeni, R., ... & Cunningham, V. J. A pharmacokinetic PET study of NK1 receptor occupancy. Eur J Nucl Med Mol Imaging, 2012, 39(2), 226-235. doi: 10.1007/s00259-011-1954-2. (6/2/15, 형성우)
# Zamuner, S., Rabiner, E. A., Fernandes, S. A., Bani, M., Gunn, R. N., Gomeni, R., ... & Cunningham, V. J. A pharmacokinetic PET study of NK1 receptor occupancy. Eur J Nucl Med Mol Imaging, 2012, 39(2), 226-235. doi: 10.1007/s00259-011-1954-2. (6/2/15, 형성우)
# Cvetkovic M1, Leake B, Fromm MF, Wilkinson GR, Kim RB. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. (PMID: 10421612) (6/9/15, 송유경)
# Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. (PMID: 10421612) (6/9/15, 송유경)
# Win KY, Feng SS. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials. 2005 May;26(15):2713-22. doi:10.1016/j.biomaterials.2004.07.050 (PMID: 15585275) (6/16/15, 남지우)
# Hallifax D, Foster JA, Houston JB. Prediction of human metabolic clearance from in vitro systems: retrospective analysis and prospective view. Pharm Res. 2010 Oct;27(10):2150-61. doi: 10.1007/s11095-010-0218-3 (PMID: 20661765) (6/23/15, 임창순)


==Discussed articles (2014 Fall)==
==Discussed articles (2014 Fall)==

Revision as of 00:57, 2 July 2015

Pharmaceutics JC at SNU

JC Schedule

Tue, 4 - 6 pm (Building 143, Rm 107, 일동홀)

Journal articles to be distributed to everyone by Wed prior to JC!

Date Discussion leader
3/24/15 정유성
3/31/15 no JC (reading assignment 1)
4/7/15 노치경
4/14/15 유헌민
4/21/15 no JC (reading assignment 2)
4/28/15 천세은
5/12/15 편원지
5/19/15 김경민
5/26/15 홍은진
6/2/15 형성우
6/9/15 송유경
6/16/15 남지우
6/23/15 임창순


Discussed articles (2015 Spring)

  1. Kikuchi R, Yagi S, Kusuhara H, Imai S, Sugiyama Y, Shiota K. Genome-wide analysis of epigenetic signatures for kidney-specific transporters. Kidney Int. 2010 Sep;78(6):569-77. doi: 10.1038/ki.2010.176. (PMID: 20555317) (3/24/15, 정유성)
  2. Li, J., Volpe, D. A., Wang, Y., Zhang, W., Bode, C., Owen, A., & Hidalgo, I. J. Use of transporter knockdown Caco-2 cells to investigate the in vitro efflux of statin drugs. Drug Metabolism and Disposition, 2011, 39(7), 1196-1202. doi: 1124/dmd.111.038075 (PMID: 21447733) (4/7/15, 노치경)
  3. Cummins CL, Salphati L, Reid MJ, Benet LZ. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. J Pharmacol Exp Ther. 2003 Apr;305(1):306-14. doi: 10.1124/jpet.102.044719 (PMID: 12649383) (4/14/15, 유헌민)
  4. Zhang P, Tian X, Chandra P, Brouwer KL. Role of glycosylation in trafficking of Mrp2 in sandwich-cultured rat hepatocytes. Mol Pharmacol. 2005 Apr;67(4):1334-41. doi: 10.1124/mol.104.004481 (PMID: 15662046) (4/28/15, 천세은)
  5. Fenart L, Buée-Scherrer V, Descamps L, Duhem C, Poullain MG, Cecchelli R, Dehouck MP. Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier. Pharm Res. 1998 Jul;15(7):993-1000. (PMID: 9688050) (5/12/15, 편원지)
  6. Vallon V1, Eraly SA, Wikoff WR, Rieg T, Kaler G, Truong DM, Ahn SY, Mahapatra NR, Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, Nigam SK. Organic anion transporter 3 contributes to the regulation of blood pressure. J Am Soc Nephrol. 2008 Sep;19(9):1732-40. doi: 10.1681/ASN.2008020180. (PMID: 18508962) (5/19/15, 김경민)
  7. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8. doi: 10.1073/pnas. (PMID: 24961373) (5/26/15, 홍은진)
  8. Zamuner, S., Rabiner, E. A., Fernandes, S. A., Bani, M., Gunn, R. N., Gomeni, R., ... & Cunningham, V. J. A pharmacokinetic PET study of NK1 receptor occupancy. Eur J Nucl Med Mol Imaging, 2012, 39(2), 226-235. doi: 10.1007/s00259-011-1954-2. (6/2/15, 형성우)
  9. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. (PMID: 10421612) (6/9/15, 송유경)
  10. Win KY, Feng SS. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials. 2005 May;26(15):2713-22. doi:10.1016/j.biomaterials.2004.07.050 (PMID: 15585275) (6/16/15, 남지우)
  11. Hallifax D, Foster JA, Houston JB. Prediction of human metabolic clearance from in vitro systems: retrospective analysis and prospective view. Pharm Res. 2010 Oct;27(10):2150-61. doi: 10.1007/s11095-010-0218-3 (PMID: 20661765) (6/23/15, 임창순)

Discussed articles (2014 Fall)

  1. Iusuf D, Hendrikx JJ, van Esch A, van de Steeg E, Wagenaar E, Rosing H, Beijnen JH, Schinkel AH. Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel. Int J Cancer. 2014 May 13. doi: 10.1002/ijc.28970. (9/29/14, W)
  2. Kunze A, Huwyler J, Camenisch G, Poller B. Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data. Drug Metab Dispos. 2014 Sep;42(9):1514-21. doi: 10.1124/dmd.114.058412. (10/20/14, 정유성)
  3. Tsuda M , Terada T, Ueba M, Sato T, Masuda S, Katsura T, Inui K. Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells.J Pharmacol Exp Ther. 2009 Apr;329(1):185-91. doi: 10.1124/jpet.108.147918. (10/27/14, 천세은)
  4. Watanabe T, Kusuhara H, Watanabe T, Debori Y, Maeda K, Kondo T, Nakayama H, Horita S, Ogilvie BW, Parkinson A, Hu Z, Sugiyama Y. Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8. doi: 10.1124/dmd.110.036129. (11/10/14, 김경민)
  5. Kato K, Mori H, Kito T, Yokochi M, Ito S, Inoue K, Yonezawa A, Katsura T, Kumagai Y, Yuasa H, Moriyama Y, Inui K, Kusuhara H, Sugiyama Y. Investigation of endogenous compounds for assessing the drug interactions in the urinary excretion involving multidrug and toxin extrusion proteins. Pharm Res. 2014 Jan;31(1):136-47. doi: 10.1007/s11095-013-1144-y. (11/24/14, 송유경)
  6. Dufek MB, Knight BM, Bridges AS, Thakker DR. P-glycoprotein increases portal bioavailability of loperamide in mouse by reducing first-pass intestinal metabolism. Drug Metab Dispos. 2013 Mar;41(3):642-50. doi: 10.1124/dmd.112.049965. (12/08/14, 유헌민)
  7. Kasichayanula S, Chang M, Liu X, Shyu WC, Griffen SC, LaCreta FP, Boulton DW. Lack of pharmacokinetic interactions between dapagliflozin and simvastatin, valsartan, warfarin, or digoxin. Adv Ther. 2012 Feb;29(2):163-77. doi: 10.1007/s12325-011-0098-x. (12/15/14, 형성우)

Suggested articles

  1. Kodan A, Yamaguchi T, Nakatsu T, Sakiyama K, Hipolito CJ, Fujioka A, Hirokane R, Ikeguchi K, Watanabe B, Hiratake J, Kimura Y, Suga H, Ueda K, Kato H. Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4049-54. doi: 10.1073/pnas.1321562111
  2. Imai S, Kikuchi R, Tsuruya Y, Naoi S, Nishida S, Kusuhara H, Sugiyama Y. Epigenetic regulation of organic anion transporting polypeptide 1B3 in cancer cell lines. Pharm Res. 2013 Nov;30(11):2880-90. doi: 10.1007/s11095-013-1117-1
  3. Cvetkovic M1, Leake B, Fromm MF, Wilkinson GR, Kim RB. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71.
  4. Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM.OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9983-8. doi: 10.1073/pnas.1314939111.

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