Peyton:Research: Difference between revisions

Latest revision as of 21:24, 5 December 2013

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-== Engineered Materials to Study Mechanisms of Stem Cell Motility in Metastasis ==
-The overwhelming cause of morbidity in cancer patients is metastasis: the ability of tumor cells to mobilize, leave the primary tumor site, invade distant tissue, and launch secondary tumors.  In 1889, Dr. Steven Paget analyzed data from hundreds of breast cancer fatalities and noted that metastases were most often found in a specific subset of organs, e.g. the lung and liver.  In addition to the primary site, the pre-metastatic niche is also an area of inflammation, and stem cells (mesenchymal, hematopoietic, and endothelial progenitors) are recruited to this distant site before the arrival of metastatic tumor cells.  These stem cells initiate the premetastatic niche by remodeling the local tissue microenvironment, altering matrix physicochemical properties, and attracting circulating tumor cells.  We are using engineered materials to study this metastatic cascade of events: stem cell-tumor cell crosstalk, stem cell mobilization and ensuing adhesion, proliferation, and remodeling of the pre-metastatic tissue, and the preferential attraction of circulating tumor cells.
+==We Have Moved!==
-[[Image:NewInnovator.jpg|center|500px]]
+Check out [http://www.peytonlab.org Peytonlab.Org]