Peyton - Revision history

Shelly Peyton at 18:42, 3 March 2013

Shelly Peyton — Sun, 03 Mar 2013 18:42:27 GMT

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		+	\| '''Barry and Afsanah Siadat'''
	\| [[Image:NSF-logo.jpg\|left\|100px]]		\| [[Image:NSF-logo.jpg\|left\|100px]]
	\| [[Image:NCI-logo.jpg\|left\|100px]]		\| [[Image:NCI-logo.jpg\|left\|100px]]

Shelly Peyton at 20:48, 16 November 2012

Shelly Peyton — Fri, 16 Nov 2012 20:48:42 GMT

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	\| [[Image:MRSEC_UMass.jpg\|left\|100px]]		\| [[Image:MRSEC_UMass.jpg\|left\|100px]]
	\| [[Image:Umass_logo.jpg\|center\|100px]]		\| [[Image:Umass_logo.jpg\|center\|100px]]

Shelly Peyton at 20:44, 16 November 2012

Shelly Peyton — Fri, 16 Nov 2012 20:44:30 GMT

←Older revision		Revision as of 20:44, 16 November 2012
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		+	\| [[Image:NSF-logo.jpg\|left\|100px]]
	\| [[Image:MRSEC_UMass.jpg\|left\|100px]]		\| [[Image:MRSEC_UMass.jpg\|left\|100px]]
	\| [[Image:Umass_logo.jpg\|center\|100px]]		\| [[Image:Umass_logo.jpg\|center\|100px]]

Shelly Peyton at 13:29, 4 February 2012

Shelly Peyton — Sat, 04 Feb 2012 13:29:25 GMT

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	<div style="padding: .4em .9em .9em">		<div style="padding: .4em .9em .9em">

-	== ~~Welcome to the~~ Peyton Lab ==	+	== The Peyton Lab: Engineering Migration ''to the max'' ==

-	~~Our~~ lab ~~focuses on diseases of~~ the ~~human body that are critically impacted by improper cell migration~~. We use polymeric biomaterials to create ~~mimics of the natural migratory microenvironment and study how cues from the ECM can direct cell migration~~ ''~~in vitro~~''~~. The vast majority of tissues~~ in the ~~human~~ body ~~are comprised of~~ cells ~~surrounded by a complex network of proteins~~ and ~~polysaccharides called~~ the ~~ECM~~. ~~It is becoming increasingly clear that~~ the ~~ECM possesses several properties~~, such as ~~mechanical integrity, adhesion specificity,~~ and ~~growth factor availability~~, ~~which~~ are ~~all individually and collectively critical~~ in ~~dictating~~ the ~~local cell and~~ tissue ~~behavior~~.	+	We are a lab in Chemical Engineering, and our goal is to find cures to disease through the use of novel engineered models to tissue. We use polymeric biomaterials to create small ''model tissues'', that trick cells into thinking they are actually in the body, and then study how cells move and respond to the physical and chemical properties of their surrounding tissue. Certain diseases of the human body, such as cardiovascular disease and cancer, are particularly dangerous because of how cells migrate in the diseased tissue. <br>

-	~~The~~ mission ~~of the Peyton lab~~ is to learn how a variety of different cell types are able to process information from ~~biochemical~~ and ~~biophysical~~ cues from the ~~ECM~~ and make decisions about migration ~~and phenotype. To do this, our lab uses both 2D and 3D biomaterial model systems, which can be engineered from the ground-up to instruct cells via both biochemical and biophysical signaling pathways~~. This broader mission ~~will be~~ focused onto ~~different research avenues with~~ applications toward: cardiovascular disease, where ~~tissue homeostasis is normally maintained~~ in ~~a mechanically dynamic ECM~~; ~~stem-cell therapeutics~~, ~~where rational scaffold design may be the key to directing appropriate progenitor~~ cell migration ~~and differentiation~~ for ~~tissue regeneration; and~~ cancer, where ~~disruptions~~ in the ~~local ECM microenvironment may cause drastic changes in individual cell motility~~ and ~~phenotype~~.	+	We are several women and men, all engineers, and our mission is to learn how a variety of different cell types are able to process information from chemical and physical cues from the surrounding tissue and make decisions about migration. This broader mission is focused onto specific applications toward: cardiovascular disease, where plaque formation in arteries causes smooth muscle cells to migrate and further block blood flow, causing heart attacks and stroke; cancer, cell migration out of the primary tumor is the cause for 9 out of every 10 cancer deaths, and stem cell engineering, where we are trying to create novel scaffolds that will carry stem cells in them to treat wounded soldiers. <br>
		+
		+	Here's us from the summer of 2011, taking a well-deserved break and enjoying the music and scenery of the Boston Symphony Orchestra at Tanglewood.

	[[Image:peyton_tanglewood.jpg\|center\|500px]]		[[Image:peyton_tanglewood.jpg\|center\|500px]]
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-	Thanks to our funding sources!!!	+	Thanks to our funding sources - you support our students and help us make this research happen!
-		+

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-	Members of the Peyton lab participate in three outstanding collaborative institutes at UMass-Amherst. Follow the links for more information!	+	Members of the Peyton lab participate in three outstanding collaborative institutes at UMass-Amherst. Follow the links for more information.

	[http://www.pse.umass.edu/mrsec/ The Materials Research Science and Engineering Center]		[http://www.pse.umass.edu/mrsec/ The Materials Research Science and Engineering Center]

Shelly Peyton at 12:44, 26 July 2011

Shelly Peyton — Tue, 26 Jul 2011 12:44:09 GMT

←Older revision		Revision as of 12:44, 26 July 2011
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	The mission of the Peyton lab is to learn how a variety of different cell types are able to process information from biochemical and biophysical cues from the ECM and make decisions about migration and phenotype. To do this, our lab uses both 2D and 3D biomaterial model systems, which can be engineered from the ground-up to instruct cells via both biochemical and biophysical signaling pathways. This broader mission will be focused onto different research avenues with applications toward: cardiovascular disease, where tissue homeostasis is normally maintained in a mechanically dynamic ECM; stem-cell therapeutics, where rational scaffold design may be the key to directing appropriate progenitor cell migration and differentiation for tissue regeneration; and cancer, where disruptions in the local ECM microenvironment may cause drastic changes in individual cell motility and phenotype.		The mission of the Peyton lab is to learn how a variety of different cell types are able to process information from biochemical and biophysical cues from the ECM and make decisions about migration and phenotype. To do this, our lab uses both 2D and 3D biomaterial model systems, which can be engineered from the ground-up to instruct cells via both biochemical and biophysical signaling pathways. This broader mission will be focused onto different research avenues with applications toward: cardiovascular disease, where tissue homeostasis is normally maintained in a mechanically dynamic ECM; stem-cell therapeutics, where rational scaffold design may be the key to directing appropriate progenitor cell migration and differentiation for tissue regeneration; and cancer, where disruptions in the local ECM microenvironment may cause drastic changes in individual cell motility and phenotype.

-	[[Image:~~Website_flow~~.jpg\|center\|500px]]	+	[[Image:peyton_tanglewood.jpg\|center\|500px]]

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Shelly Peyton at 23:19, 3 June 2011

Shelly Peyton — Fri, 03 Jun 2011 23:19:02 GMT

←Older revision		Revision as of 23:19, 3 June 2011
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	Thanks to our funding sources!!!		Thanks to our funding sources!!!
-	~~[[Image:ICE_logo.jpg\|right\|100px]][[Image:Umass_logo.jpg\|center\|100px]][[Image:MRSEC_UMass.jpg\|left\|100px]]~~
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		+	\| [[Image:Umass_logo.jpg\|center\|100px]]
		+	\| [[Image:ICE_logo.jpg\|right\|100px]]
		+	\|}

Shelly Peyton at 23:15, 3 June 2011

Shelly Peyton — Fri, 03 Jun 2011 23:15:16 GMT

←Older revision		Revision as of 23:15, 3 June 2011
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	Thanks to our funding sources!!!		Thanks to our funding sources!!!
-	[[Image:ICE_logo.jpg\|right\|100px]]	+	[[Image:ICE_logo.jpg\|right\|100px]][[Image:Umass_logo.jpg\|center\|100px]][[Image:MRSEC_UMass.jpg\|left\|100px]]
-	[[Image:Umass_logo.jpg\|center\|100px]]	+
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Shelly Peyton at 23:14, 3 June 2011

Shelly Peyton — Fri, 03 Jun 2011 23:14:59 GMT

←Older revision		Revision as of 23:14, 3 June 2011
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	Thanks to our funding sources!!!		Thanks to our funding sources!!!
-		+	[[Image:ICE_logo.jpg\|right\|100px]]
-	[[Image:~~MRSEC_UMass~~.jpg\|~~left~~\|100px]] [[Image:Umass_logo.jpg\|center\|100px]] [[Image:~~ICE_logo~~.jpg\|~~right~~\|100px]]	+	[[Image:Umass_logo.jpg\|center\|100px]]
		+	[[Image:MRSEC_UMass.jpg\|left\|100px]]

Shelly Peyton at 23:14, 3 June 2011

Shelly Peyton — Fri, 03 Jun 2011 23:14:11 GMT

←Older revision		Revision as of 23:14, 3 June 2011
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Shelly Peyton at 23:13, 3 June 2011

Shelly Peyton — Fri, 03 Jun 2011 23:13:48 GMT

←Older revision		Revision as of 23:13, 3 June 2011
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	Thanks to our funding sources!!!		Thanks to our funding sources!!!

-	[[Image:MRSEC_UMass.jpg\|left\|100px]]	+	[[Image:MRSEC_UMass.jpg\|left\|100px]] [[Image:Umass_logo.jpg\|center\|100px]] [[Image:ICE_logo.jpg\|right\|100px]]
-	[[Image:Umass_logo.jpg\|center\|100px]]	+
-	[[Image:ICE_logo.jpg\|right\|100px]]	+

←Older revision		Revision as of 18:42, 3 March 2013
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	{\|		{\|
		+	\| '''Barry and Afsanah Siadat'''
	\| [[Image:NSF-logo.jpg\|left\|100px]]		\| [[Image:NSF-logo.jpg\|left\|100px]]
	\| [[Image:NCI-logo.jpg\|left\|100px]]		\| [[Image:NCI-logo.jpg\|left\|100px]]

←Older revision		Revision as of 20:48, 16 November 2012
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	{\|		{\|
	\| [[Image:NSF-logo.jpg\|left\|100px]]		\| [[Image:NSF-logo.jpg\|left\|100px]]
		+	\| [[Image:NCI-logo.jpg\|left\|100px]]
	\| [[Image:MRSEC_UMass.jpg\|left\|100px]]		\| [[Image:MRSEC_UMass.jpg\|left\|100px]]
	\| [[Image:Umass_logo.jpg\|center\|100px]]		\| [[Image:Umass_logo.jpg\|center\|100px]]

←Older revision		Revision as of 20:44, 16 November 2012
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	{\|		{\|
		+	\| [[Image:NSF-logo.jpg\|left\|100px]]
	\| [[Image:MRSEC_UMass.jpg\|left\|100px]]		\| [[Image:MRSEC_UMass.jpg\|left\|100px]]
	\| [[Image:Umass_logo.jpg\|center\|100px]]		\| [[Image:Umass_logo.jpg\|center\|100px]]