Others 10. 박재형(JaeHyung Park)

caDNAno

1. 22 (Thu)

Paper Study

1. 3 (Sat)

Folding DNA to create nanoscale shapes and patterns - DNA origami

http://www.nature.com/nature/journal/v440/n7082/full/nature04586.html#close Box file name : Nature04586(PJH).pdf, PJH150103_dna origami.pptx
link title

• DNA Structure

1. DNA is double helix structure.
2. In DNA, there are four different types of nitrogenous base.
   According to base pairing rules (A with T and C with G), hydrogen bonds bind the nitrogenous bases of the two separate polynucleotide strands to make double-stranded DNA.
   • A is for adenine
   • G is for guanine
   • C is for cytosine
   • T is for thymine

• DNA origami

1. DNA origami is the nanoscale folding of DNA to create arbitrary two- and three-dimensional shapes at the nanoscale.
2. A long single strand DNA and staple DNA strand are required
   • The use of a long single strand DNA in M13mp18.
   • Staple DNA strand folded long single strand DNA.
   • Use a computer to determine the way to create the correct staples needed to form a certain shape. And we create arbitrary two- and three-dimensional shapes at the nanoscale.

• The application of DNA origami

1. DNA origami will enable making small computer.
2. DNA origami be used to create nanorobots capable of finding and destroying cancer cells in the human body.

• Consideration

DNA origami was very impressive and DNA origami technology development will continue.
So DNA origami can be adapted to create more complex or larger structures.