OpenSourceMalaria:Other GSK Series Under Consideration

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
(added hyperlinks)
(edited text)
Line 8: Line 8:
[[Image:TCMDC137322.png|thumb|center|540px|Scheme 1: TCMDC 137332]] <br>
[[Image:TCMDC137322.png|thumb|center|540px|Scheme 1: TCMDC 137332]] <br>
-
InChI=1S/C17H18ClNO2/c1-17(2,3)16(20)19-14-6-4-5-7-15(14)21-13-10-8-12(18)9-11-13/h4-11H,1-3H3,(H,19,20)
+
InChI=1S/C17H18ClNO2/c1-17(2,3)16(20)19-14-6-4-5-7-15(14)21-13-10-8-12(18)9-11-13/h4-11H,1-3H3,(H,19,20) <br>
-
ClC(C=C1)=CC=C1OC2=CC=CC=C2NC(C(C)(C)C)=O
+
ClC(C=C1)=CC=C1OC2=CC=CC=C2NC(C(C)(C)C)=O <br>
'''Citations for exact structure search:''' <br>
'''Citations for exact structure search:''' <br>
-
1. [http://pubs.acs.org/doi/abs/10.1021/ml200135p DOI:10.1021/ml200135p] – GSK Paper on Open Innovation
+
1. [http://pubs.acs.org/doi/abs/10.1021/ml200135p DOI:10.1021/ml200135p] – GSK Paper on Open Innovation <br>
-
2. WO 1994-GB1409 – Preparation of anti-atherosclerotic diaryl compound, The Wellcome Foundation <br>
+
2. [http://patentscope.wipo.int/search/en/WO1995001326 WO 1994-GB1409] – Preparation of anti-atherosclerotic diaryl compound, The Wellcome Foundation <br>
''Atherosclerosis  –  The clogging or hardening of arteries or blood vessels caused by plaques (accumulations of fatty deposits, usually cholesterol'' <br>
''Atherosclerosis  –  The clogging or hardening of arteries or blood vessels caused by plaques (accumulations of fatty deposits, usually cholesterol'' <br>
'''InChi Search:''' <br>
'''InChi Search:''' <br>
-
No hits on Google
+
No hits on Google <br>
'''Citations for sub-structure search:''' <br>
'''Citations for sub-structure search:''' <br>
-
1. WO 2000-EP1224 –  Preparation of phenyl and pyridinyl derivatives as NK-1 receptor antagonists, F. Hoffmann La Roche <br>
+
1. WO 2000-EP1224 –  Preparation of phenyl and pyridinyl derivatives as NK-1 receptor antagonists, ''F. Hoffmann La Roche'' <br>
''Neurokinin 1 (NK), Antagonists – Novel class of medication possessing antidepressant, anxiolytic and antiemetic action'' <br>
''Neurokinin 1 (NK), Antagonists – Novel class of medication possessing antidepressant, anxiolytic and antiemetic action'' <br>
-
2. ComGenex Compound (Scheme 2)
+
2. ComGenex Compound (Scheme 2) <br>
[[Image:ComGenex.png|thumb|center|540px|Scheme 2: ComGenex Compound]] <br>
[[Image:ComGenex.png|thumb|center|540px|Scheme 2: ComGenex Compound]] <br>
-
InChI=1S/C17H17Cl2NO2/c1-17(2,3)16(21)20-13-6-4-5-7-15(13)22-14-9-8-11(18)10-12(14)19/h4-10H,1-3H3,(H,20,21)
+
InChI=1S/C17H17Cl2NO2/c1-17(2,3)16(21)20-13-6-4-5-7-15(13)22-14-9-8-11(18)10-12(14)19/h4-10H,1-3H3,(H,20,21) <br>
-
ClC(C=C1)=CC(Cl)=C1OC2=CC=CC=C2NC(C(C)(C)C)=O
+
ClC(C=C1)=CC(Cl)=C1OC2=CC=CC=C2NC(C(C)(C)C)=O <br>

Revision as of 20:04, 12 May 2013

Malaria Home        OSM So Far        Compound Series        Links        Open Source Research Home        Tech Ops        FAQ       


Other GSK Series Under Consideration

The team have focused on the synthesis and evaluation of two series (the aryl pyrroles and aminothienopyrimidines) to date. The focus of the project could change quite rapidly following the receipt of new biological data (for highly active or inactive compounds). This page highlights other GSK compounds from the TCAMS data that look attractive.

TCMDC 137332

Scheme 1: TCMDC 137332
Scheme 1: TCMDC 137332

InChI=1S/C17H18ClNO2/c1-17(2,3)16(20)19-14-6-4-5-7-15(14)21-13-10-8-12(18)9-11-13/h4-11H,1-3H3,(H,19,20)
ClC(C=C1)=CC=C1OC2=CC=CC=C2NC(C(C)(C)C)=O

Citations for exact structure search:
1. DOI:10.1021/ml200135p – GSK Paper on Open Innovation
2. WO 1994-GB1409 – Preparation of anti-atherosclerotic diaryl compound, The Wellcome Foundation
Atherosclerosis – The clogging or hardening of arteries or blood vessels caused by plaques (accumulations of fatty deposits, usually cholesterol

InChi Search:
No hits on Google

Citations for sub-structure search:
1. WO 2000-EP1224 – Preparation of phenyl and pyridinyl derivatives as NK-1 receptor antagonists, F. Hoffmann La Roche
Neurokinin 1 (NK), Antagonists – Novel class of medication possessing antidepressant, anxiolytic and antiemetic action
2. ComGenex Compound (Scheme 2)

Scheme 2: ComGenex Compound
Scheme 2: ComGenex Compound

InChI=1S/C17H17Cl2NO2/c1-17(2,3)16(21)20-13-6-4-5-7-15(13)22-14-9-8-11(18)10-12(14)19/h4-10H,1-3H3,(H,20,21)
ClC(C=C1)=CC(Cl)=C1OC2=CC=CC=C2NC(C(C)(C)C)=O

Personal tools