OpenSourceMalaria:GSK Triazolourea Singleton

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GSK Triazolourea Singleton

The triazolourea singleton has the following structure:

GSK Triazolourea Singleton: TCMDC 134395

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The proposed synthesis for this compound is below:

Proposed synthesis for the above compound

Step 3 in particular needs attention and since this is an open project, anyone can contribute to improving this synthesis. The following, from (insert citation) is a possible alternative. Any input is greatly appreciated.

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References

Yasuda, N.; Nagakura, T.; Yamazaki, K.; Yoshikawa, S.; Okuda, T.; Ikuta, H.; Koyanagi, M. ( Eisai Co., Ltd.). Preparation of N-carbamoylazoles as dipeptidyl peptidase IV inhibitors. European Patent 1 258 480 A1, 2002; SciFinder Scholar AN 2002:886010 (accessed 2/3/2012).