OpenSourceMalaria
Open Source Malaria (OSM) is aimed at finding new medicines for malaria using strictly open source principles, embodied in the 6 Laws of Open Research. At the moment the majority of work involves the synthesis of analogs of compounds identified by big pharma, with the aim of improving their potency while making the molecules more "druggable", what is known as a hit-to-lead campaign. Medicinal chemists should head to the OpenSourceMalaria:Compound_Series compound series page, in particular the most active current series, OpenSourceMalaria:Triazolopyrazine_(TP)_Series Series 4.
This wiki describes where the project is up to, and contains summaries of relevant data. For everything else about the project, see the main Project Landing Page.
About OSM
Status: A short summary of the science to date can be found in The Story So Far.
Detail on the molecules investigated can be found in The Compound Series Page, the daughter pages of which contains aggregated data about those series.
A description of what open research is can be found in the Open Research Page.
Publications from the project and other outputs are in the Links page, along with media about the project.
What's Happening and What's Needed
Daily updates (including the current To Do list) can all be accessed through the project's main Landing Page.
At the moment (November 2013) there is residual activity on Series 3, but there is now movement towards Series 4.
The main resources needed in the OSM project are experimental input, particularly chemical compound synthesis and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.
If you have no access to a lab, there are a number of important other things needed, labelled as such on the To Do List.
Still unsure? If you want to ask anything, it's best to do that in the public domain through any of the ways shown on the Landing Page but you can contact the team using opensourcemalaria@gmail.com
Help Maintain this Wiki
If you would like to improve these wiki pages, you will just need to get an OpenWetWare account (which is easy).
Licence
The OSM project's licence unless otherwise stated is CC-BY-3.0 meaning you can use whatever you want for whatever purpose, provided you cite the project.
