OpenSourceMalaria

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{{OpenSourceMalaria}}
{{OpenSourceMalaria}}
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Open Source Malaria (OSM) is aimed at finding new medicines for malaria using strictly open source principles, embodied in the [[Open_Source_Research | 6 Laws of Open Research]]. At the moment the majority of work involves the synthesis of analogs of compounds identified by big pharma, with the aim of improving their potency while making the molecules more "druggable", what is known as a hit-to-lead campaign.
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[http://opensourcemalaria.org/ Open Source Malaria (OSM)] is aimed at finding new medicines for malaria using open source principles, embodied in the [[Open_Source_Research | 6 Laws of Open Research]]. At the moment the majority of work involves the synthesis of analogs of compounds identified by big pharma, with the aim of improving their potency while making the molecules more "druggable", what is known as a "hit-to-lead" campaign.
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This wiki describes where the project is up to, and contains summaries of relevant data. For everything else about the project, see the main [http://opensourcemalaria.org/# Project Landing Page].
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Medicinal chemists should head to the [[OpenSourceMalaria:Story_so_far|project summary]], then the [[OpenSourceMalaria:Compound_Series| individual compound series page]]. The most active series at the moment is [[OpenSourceMalaria:Triazolopyrazine_(TP)_Series|Series 4]].
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== About OSM ==
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For a good general overview, see the '''April 2014 newsletter''', which can be downloaded as a PDF [http://malaria.ourexperiment.org/data/files/10840/OSM%20Newsletter%20April%202014.pdf here]. Answers to many common questions can be found in the [[OpenSourceMalaria:FAQ | FAQ]] page
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Status: A short summary of the science to date can be found in [[OpenSourceMalaria:Story_so_far|'''The Story So Far''']].
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This wiki describes where the project is up to, and archives some data and loose ends. For everything else about the project, see the main [http://opensourcemalaria.org/# Project Landing Page]. For a list of current to do items that can be filtered by type and series, see the [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?state=open To Do List].
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Detail on the molecules investigated can be found in [[OpenSourceMalaria:Compound Series|'''The Compound Series Page''']], the daughter pages of which contains aggregated data about those series.
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==About OSM, What's Needed and how to Contact==
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A description of what open research is can be found in the [[Open_Source_Research|'''Open Research Page''']].
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The background to the project may be found in the [[OpenSourceMalaria:Story_so_far|Story so Far]]. Publications from the project and other outputs are in the [[OpenSourceMalaria:Links|'''Links''']] page, along with media about the project.
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Publications from the project and other outputs are in the [[OpenSourceMalaria:Links|'''Links''']] page, along with media about the project.
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The main resources needed in the OSM project are '''experimental input''', particularly [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=Being+Synthesised+Now&page=1&state=open chemical compound synthesis] and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.
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== What's Happening and What's Needed ==
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If you have no access to a lab, there are a number of important other things needed, labelled as such on the To Do List, such as things to do with [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=Writing&milestone=&page=1&state=open writing] or [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=PR&milestone=&page=1&state=open PR] to help spread the word.
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Daily updates (including the current To Do list) can all be accessed through [http://opensourcemalaria.org/# the project's main Landing Page].
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Ideally everything happens in the public domain through any of the ways shown on the [http://opensourcemalaria.org/# Landing Page] but you can in the last resort contact the consortium using opensourcemalaria@gmail.com
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At the moment (October 2013) there is most activity on [[OpenSourceMalaria:GSK Amino-thienopyrimidine Series|'''Series 3''']], but it is likely there will soon be a shift to [[OpenSourceMalaria:Triazolopyrazine (TP) Series|'''Series 4''']].
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The main resources needed in the OSM project are '''experimental input''', particularly chemical compound synthesis and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.
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If you have no access to a lab, there are a number of important other things needed, labelled as such on the [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?state=open To Do List].
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Still unsure? If you want to ask anything, it's best to do that in the public domain through any of the ways shown on the [http://opensourcemalaria.org/# Landing Page] but you can contact the team using opensourcemalaria@gmail.com
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==Help Maintain this Wiki==
==Help Maintain this Wiki==

Current revision

Malaria Home        OSM So Far        Compound Series        Links        Open Source Research Home        Tech Ops        FAQ       


Open Source Malaria (OSM) is aimed at finding new medicines for malaria using open source principles, embodied in the 6 Laws of Open Research. At the moment the majority of work involves the synthesis of analogs of compounds identified by big pharma, with the aim of improving their potency while making the molecules more "druggable", what is known as a "hit-to-lead" campaign.

Medicinal chemists should head to the project summary, then the individual compound series page. The most active series at the moment is Series 4.

For a good general overview, see the April 2014 newsletter, which can be downloaded as a PDF here. Answers to many common questions can be found in the FAQ page

This wiki describes where the project is up to, and archives some data and loose ends. For everything else about the project, see the main Project Landing Page. For a list of current to do items that can be filtered by type and series, see the To Do List.

About OSM, What's Needed and how to Contact

The background to the project may be found in the Story so Far. Publications from the project and other outputs are in the Links page, along with media about the project.

The main resources needed in the OSM project are experimental input, particularly chemical compound synthesis and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.

If you have no access to a lab, there are a number of important other things needed, labelled as such on the To Do List, such as things to do with writing or PR to help spread the word.

Ideally everything happens in the public domain through any of the ways shown on the Landing Page but you can in the last resort contact the consortium using opensourcemalaria@gmail.com

Help Maintain this Wiki

If you would like to improve these wiki pages, you will just need to get an OpenWetWare account (which is easy).

Licence

The OSM project's licence unless otherwise stated is CC-BY-3.0 meaning you can use whatever you want for whatever purpose, provided you cite the project.

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