OpenSourceMalaria

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{{OSDDMalaria}}
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{{OpenSourceMalaria}}
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A hub for global efforts in open source drug discovery for malaria. If you are interested in open source drug discovery and would like to do something to combat malaria, then:
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[http://opensourcemalaria.org/ Open Source Malaria (OSM)] is aimed at finding new medicines for malaria using open source principles, embodied in the [[Open_Source_Research | 6 Laws of Open Research]]. At the moment the majority of work involves the synthesis of analogs of compounds identified by big pharma, with the aim of improving their potency while making the molecules more "druggable", what is known as a "hit-to-lead" campaign.
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* Get an OpenWetWare account
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Medicinal chemists should head to the [[OpenSourceMalaria:Story_so_far|project summary]], then the [[OpenSourceMalaria:Compound_Series| individual compound series page]]. The most active series at the moment is [[OpenSourceMalaria:Triazolopyrazine_(TP)_Series|Series 4]].
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* Edit this and other pages.
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* Contribute to current projects or even start new ones!
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== Meetings ==
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This wiki describes where the project is up to, and archives some data and loose ends. For everything else about the project, see the main [http://opensourcemalaria.org/# Project Landing Page]. For a list of current to do items that can be filtered by type and series, see the [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?state=open To Do List].
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[[OSDDMalaria:OSDD_Malaria_Meeting_Sydney_2012|OSDDMalaria Meeting]] - University of Sydney, 24 February 2012
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==About OSM, What's Needed and how to Contact==
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=== Current Participants ===
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The background to the project may be found in the [[OpenSourceMalaria:Story_so_far|Story so Far]]. Publications from the project and other outputs are in the [[OpenSourceMalaria:Links|'''Links''']] page, along with media about the project.
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==== Medicinal Chemistry ====
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The main resources needed in the OSM project are '''experimental input''', particularly [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=Being+Synthesised+Now&page=1&state=open chemical compound synthesis] and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.
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* [[Todd| Todd Group]] at the [http://sydney.edu.au/science/chemistry/ University of Sydney]
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If you have no access to a lab, there are a number of important other things needed, labelled as such on the To Do List, such as things to do with [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=Writing&milestone=&page=1&state=open writing] or [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?labels=PR&milestone=&page=1&state=open PR] to help spread the word.
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* [http://www.mmv.org/ Medicines for Malaria Venture]
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* [http://www.cdriindia.org/sanjay.htm Sanjay Batra] at [http://www.cdriindia.org/home.asp CDRI India]
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* [http://malaria.osdd.net/ OSDDm] project at [http://www.osdd.net/about-us/osdd-malaria OSDD CDRI]
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==== Biology ====
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Ideally everything happens in the public domain through any of the ways shown on the [http://opensourcemalaria.org/# Landing Page] but you can in the last resort contact the consortium using opensourcemalaria@gmail.com
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* [http://www.discoverybiology.org/team/vicky-avery Avery Group] at Discovery Biology, Griffith University
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==Help Maintain this Wiki==
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* [http://www.bio21.org/group-leaders/bio-chemistry/stuart-ralph Ralph Group], Bio21, Melbourne
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* [http://www.openlabfoundation.org/gsk.aspx GSK Tres Cantos], Spain
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== Current Projects ==
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If you would like to improve these wiki pages, you will just need to get an OpenWetWare account ([[OpenWetWare:How_to_join |which is easy]]).
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There are lots of things needed, but the main thing is experimental input. If you're a scientist with access to a lab, open source drug discovery needs you in particular. If you want to know what open source drug discovery is, go [[OSDD:Huh%3F|here]]. For anyone new to the project here is a [[short guide to using the Electronic Lab Notebook]].
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==Licence==
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Currently there is an active project on-going:
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The OSM project's licence unless otherwise stated is [http://creativecommons.org/licenses/by/3.0/ CC-BY-3.0] meaning you can use whatever you want for whatever purpose, provided you cite the project.
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* [[OSDDMalaria:GSK_Arylpyrrole_Series|GSK arylpyrrole series]]
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* [[OSDDMalaria:GSK_Triazolourea_Singleton|GSK Triazolourea Singleton]]
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* [[OSDDMalaria:GSK_Amino-thienopyrimidine_Series|GSK Amino-thienopyrimidine Series]]
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Project entries will be listed at [[OSDDMalaria:Projects|link]] in above menu.
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== Discussion ==
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This is a wiki, meaning it's meant as a site for how projects are going. For discussion try [http://www.thesynapticleap.org/malaria/community The Synaptic Leap], and for feeds try the [http://twitter.com/#!/osddmalaria Twitter feed]. If you would like access to the Twitter account, in order to help post updates about malaria projects, please email OSDD.Malaria@gmail.com.
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Relevant papers are available in the [http://www.mendeley.com/groups/1846251/osddmalaria/ Mendeley group], please feel free to add new relevant content anywhere!
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Revision as of 19:26, 20 January 2014

Malaria Home        OSM So Far        Compound Series        Links        Open Source Research Home        Technical Operations       


Open Source Malaria (OSM) is aimed at finding new medicines for malaria using open source principles, embodied in the 6 Laws of Open Research. At the moment the majority of work involves the synthesis of analogs of compounds identified by big pharma, with the aim of improving their potency while making the molecules more "druggable", what is known as a "hit-to-lead" campaign.

Medicinal chemists should head to the project summary, then the individual compound series page. The most active series at the moment is Series 4.

This wiki describes where the project is up to, and archives some data and loose ends. For everything else about the project, see the main Project Landing Page. For a list of current to do items that can be filtered by type and series, see the To Do List.

About OSM, What's Needed and how to Contact

The background to the project may be found in the Story so Far. Publications from the project and other outputs are in the Links page, along with media about the project.

The main resources needed in the OSM project are experimental input, particularly chemical compound synthesis and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.

If you have no access to a lab, there are a number of important other things needed, labelled as such on the To Do List, such as things to do with writing or PR to help spread the word.

Ideally everything happens in the public domain through any of the ways shown on the Landing Page but you can in the last resort contact the consortium using opensourcemalaria@gmail.com

Help Maintain this Wiki

If you would like to improve these wiki pages, you will just need to get an OpenWetWare account (which is easy).

Licence

The OSM project's licence unless otherwise stated is CC-BY-3.0 meaning you can use whatever you want for whatever purpose, provided you cite the project.

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