OpenSourceMalaria

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{{OSDDMalaria}}
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{{OpenSourceMalaria}}
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A hub for global efforts in open source drug discovery for malaria. If you are interested in open source drug discovery and would like to do something to combat malaria, then:
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Open Source Malaria (OSM, pronounced "''awesome''") is aimed at finding new medicines for malaria using strictly open source principles, embodied in the [[Open_Source_Research | 6 Laws of Open Research]].
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* Get an OpenWetWare account
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This wiki describes where the project is up to, and summaries of relevant data. For other aspects of the project, see the main [http://opensourcemalaria.org/# Project Landing Page].
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* Edit this and other pages.
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* Contribute to current projects (below) or even start new ones!
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== Current Projects ==
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If you would like to improve these wiki pages, you will need to get an OpenWetWare account ([[OpenWetWare:How_to_join |which is easy]]).
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There are lots of things needed, but the main thing is experimental input. If you're a scientist with access to a lab, open source drug discovery needs you. If you want to know what open source drug discovery is, go [[OSDD:Huh%3F|here]]. For anyone new to the project here is a [[short guide to using the Electronic Lab Notebook]].
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== About the Malaria Project ==
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Currently there are three active projects on-going:
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A human-friendly summary of the science to date can be found in [[OpenSourceMalaria:Story_so_far|'''The Story So Far''']].
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* [[OSDDMalaria:GSK_Arylpyrrole_Series|GSK arylpyrrole series]] - plus a [[OSDDMalaria:GSK Arylpyrrole Series:Story so far|human-readable summary]] of the current project status.
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A description of what open research is can be found in the [[Open_Source_Research|'''Open Research Page''']].
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* [[OSDDMalaria:GSK_Triazolourea_Singleton|GSK Triazolourea Singleton]]
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* [[OSDDMalaria:GSK_Amino-thienopyrimidine_Series|GSK Amino-thienopyrimidine Series]]
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Project entries will be listed at [[OSDDMalaria:Projects|link]] in above menu.
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Aggregated data on various branches of the project so far can be found on the [[OpenSourceMalaria:Compound_Series|Compound Series Page]].
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=== Current Participants ===
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See publications from the project and what other people have written about it on the [[OpenSourceMalaria:Links|'''Links''']] page.
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==== Medicinal Chemistry ====
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== What's Happening and What's Needed ==
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* [[Todd| Todd Group]] at the [http://sydney.edu.au/science/chemistry/ University of Sydney] 
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Daily updates (including the To Do list) can be accessed through [http://opensourcemalaria.org/# the project's main hub].
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* [http://www.mmv.org/ Medicines for Malaria Venture]
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* [http://www.cdriindia.org/sanjay.htm Sanjay Batra] at [http://www.cdriindia.org/home.asp CDRI India]
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* [http://malaria.osdd.net/ OSDDm] project at [http://www.osdd.net/about-us/osdd-malaria OSDD CDRI]
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==== Biology ====
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At the moment (July 2013) there is most activity on [[OpenSourceMalaria:GSK_Amino-thienopyrimidine_Series|'''Series 2''']], with the raw data in [http://malaria.ourexperiment.org/aminotpseries this lab notebook].
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* [http://www.discoverybiology.org/team/vicky-avery Avery Group] at Discovery Biology, Griffith University
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The main resources needed in the OSM project are '''experimental input''', particularly chemical compound synthesis and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.
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* [http://www.bio21.org/group-leaders/bio-chemistry/stuart-ralph Ralph Group], Bio21, Melbourne
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* [http://www.openlabfoundation.org/gsk.aspx GSK Tres Cantos], Spain
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* [http://www.monash.edu.au/research/profiles/profile.html?sid=2143&pid=3154 Charman Group], Monash University
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==Open Source Drug Discovery More Generally==
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If you have no access to a lab, there are a number of important other things needed, labelled as such on the [https://github.com/OpenSourceMalaria/OSM_To_Do_List/issues?state=open To Do List].
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A [http://openwetware.org/wiki/OSDDMalaria:OSDD_Malaria_Meeting_Sydney_2012 one-day meeting on open source drug discovery for malaria] was held in February 2012. General issues surrounding the feasibility of open source drug discovery were discussed, followed by more specific malaria-related ideas. These talks are gradually [http://www.youtube.com/playlist?list=PL84A4E62C3C72863D going up on YouTube] with [http://www.thesynapticleap.org/node/390 annotations], and they frame many of the relevant issues, for example the landscape of drug discovery in neglected diseases, and whether patents are necessary in drug discovery. An important message is that open ''source'' drug discovery is where anyone may participate in driving the research, which is different from a more general use of the word "open" where data are made freely available, but perhaps after a delay which essentially prevents participation by others.
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==Licence==
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==How We Run the Project==
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The OSM project's licence unless otherwise stated is [http://creativecommons.org/licenses/by/3.0/ CC-BY-3.0] meaning you can use whatever you want for whatever purpose, provided you cite the project.
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The way the project is run is one of the novelties, though as with everything in this project nothing is static and advice is always welcome on improvements. Raw experimental data are recorded in an online, openly-readable [http://malaria.ourexperiment.org/ electronic lab notebook]. [http://www.thesynapticleap.org/malaria/community The Synaptic Leap] is being used to discuss ideas and results, as well as plan future work. The project's [https://plus.google.com/u/0/b/114702323662314783325/114702323662314783325/posts Google+ page] is a light way to keep up with developments and discuss. The project's [https://twitter.com/#!/OSDDMalaria Twitter feed] is a broadcast mechanism for updates. LinkedIn as used in the past on another project as a way of connecting with relevant experts, but has not been used much so far in this project. A [http://openwetware.org/wiki/Open_Source_Drug_Discovery_-_Malaria wiki] (that includes this page) is used to host the current overall project status. Updates on the project's progress can also be found at our  [http://www.facebook.com/OSDDforMalaria Facebook page], and this also a place for interaction. If you wish to participate in this project, you can sign up to all these sites, and you would then be sent the Twitter/G+ passwords so you can used the same accounts.
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== Discussion ==
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This is a wiki, meaning it's meant as a site for how projects are going. For discussion try [http://www.thesynapticleap.org/malaria/community The Synaptic Leap], or the project's [https://plus.google.com/u/0/b/114702323662314783325/114702323662314783325/posts Google+ page], and for updates try the [http://twitter.com/#!/osddmalaria Twitter feed] and [http://www.facebook.com/OSDDforMalaria Facebook Page]. If you would like access to the Twitter or G+ accounts because you've become a member of the project please email OSDD.Malaria@gmail.com.
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Relevant papers are available in the [http://www.mendeley.com/groups/1846251/osddmalaria/ Mendeley group], to which anyone can add.
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Revision as of 18:19, 8 July 2013

Malaria Home        OSM So Far        Compound Series        Links        Open Source Research Home        Tech Ops        FAQ       


Open Source Malaria (OSM, pronounced "awesome") is aimed at finding new medicines for malaria using strictly open source principles, embodied in the 6 Laws of Open Research.

This wiki describes where the project is up to, and summaries of relevant data. For other aspects of the project, see the main Project Landing Page.

If you would like to improve these wiki pages, you will need to get an OpenWetWare account (which is easy).

About the Malaria Project

A human-friendly summary of the science to date can be found in The Story So Far.

A description of what open research is can be found in the Open Research Page.

Aggregated data on various branches of the project so far can be found on the Compound Series Page.

See publications from the project and what other people have written about it on the Links page.

What's Happening and What's Needed

Daily updates (including the To Do list) can be accessed through the project's main hub.

At the moment (July 2013) there is most activity on Series 2, with the raw data in this lab notebook.

The main resources needed in the OSM project are experimental input, particularly chemical compound synthesis and help with chem/bioinformatics. Anyone can make compounds, get them tested and contribute data. You don't have to be a research scientist - maybe you're an undergrad doing a lab.

If you have no access to a lab, there are a number of important other things needed, labelled as such on the To Do List.

Licence

The OSM project's licence unless otherwise stated is CC-BY-3.0 meaning you can use whatever you want for whatever purpose, provided you cite the project.

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