OhioMod2013:Design/NuclearPore: Difference between revisions
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[[Image:NuclearPore.jpg|center|600px]] | [[Image:NuclearPore.jpg|center|600px]] | ||
*Image courtesy of Martin Goldberg | *Image courtesy of Martin Goldberg | ||
*Left image: Cytosol side of the membrane. Composed of the cytoplasmic ring, of eight 50 nm long cytoplasmic filaments, with a gap of 70 nm. | *Left image: Cytosol side of the membrane. Composed of the cytoplasmic ring, of eight 50 nm long cytoplasmic filaments, with a gap of 70 nm. These filaments are assymetrical and connect the core structure to the cytoskeleton and protein synthesis assembly lines. | ||
*Right image: Nucleus side of the membrane. Composed of nuclear filaments joining to create a basket-like ring with a gapa of 30-50 nm. The central pore itself has a gap of 45-50 nm. | *Right image: Nucleus side of the membrane. Composed of nuclear filaments joining to create a basket-like ring with a gapa of 30-50 nm. This basket is involved with a dynamic molecular platform for nuclear activity such as transcriptional regulation . | ||
*The central pore itself has a gap of 45-50 nm. | |||
The nucleoporin is composed of around 50 different nucleoporins, which occur in multiples of eight. | The nucleoporin is composed of around 50 different nucleoporins, which occur in multiples of eight. | ||
The nuclear pore complex(NPC) is necessary for both the importing of nuclear proteins into the nucleus and the exporting of mRNA. We are soley focused on importation of genes into the nucleus, and so will be focusing on that single direction. The NPC is a selective barrier in order to prevent foreign objects from entering the nucleus that may have a malicious effect on the chromosomes. | |||
<biblio> | |||
#Nuclearpore1 pmid=16525863 | |||
#Nuclearpore2 pmid=20571586 | |||
</biblio> | |||
Revision as of 12:36, 3 June 2013
The Nuclear Pore
- Image courtesy of Martin Goldberg
- Left image: Cytosol side of the membrane. Composed of the cytoplasmic ring, of eight 50 nm long cytoplasmic filaments, with a gap of 70 nm. These filaments are assymetrical and connect the core structure to the cytoskeleton and protein synthesis assembly lines.
- Right image: Nucleus side of the membrane. Composed of nuclear filaments joining to create a basket-like ring with a gapa of 30-50 nm. This basket is involved with a dynamic molecular platform for nuclear activity such as transcriptional regulation .
- The central pore itself has a gap of 45-50 nm.
The nucleoporin is composed of around 50 different nucleoporins, which occur in multiples of eight.
The nuclear pore complex(NPC) is necessary for both the importing of nuclear proteins into the nucleus and the exporting of mRNA. We are soley focused on importation of genes into the nucleus, and so will be focusing on that single direction. The NPC is a selective barrier in order to prevent foreign objects from entering the nucleus that may have a malicious effect on the chromosomes.
- van der Aa MA, Mastrobattista E, Oosting RS, Hennink WE, Koning GA, and Crommelin DJ. The nuclear pore complex: the gateway to successful nonviral gene delivery. Pharm Res. 2006 Mar;23(3):447-59. DOI:10.1007/s11095-005-9445-4 |
- Strambio-De-Castillia C, Niepel M, and Rout MP. The nuclear pore complex: bridging nuclear transport and gene regulation. Nat Rev Mol Cell Biol. 2010 Jul;11(7):490-501. DOI:10.1038/nrm2928 |
