OSDDMalaria:GSK Triazolourea Singleton - Revision history

Jim Cronshaw: /* Analogues */

Jim Cronshaw — Fri, 25 May 2012 11:26:11 GMT

Analogues

←Older revision		Revision as of 11:26, 25 May 2012
Line 98:		Line 98:
	The compounds of concern, which we're after, can be seen here:		The compounds of concern, which we're after, can be seen here:

-	[[Image:TriazDesire1.png\|center]][[Image:~~TriazDesire22~~.png\|center]]	+	[[Image:TriazDesire1.png\|center]][[Image:TriazDesire2.png\|center]]
	[[Image:TriazDesire3.png\|center]]		[[Image:TriazDesire3.png\|center]]

Jim Cronshaw: /* Analogues */

Jim Cronshaw — Fri, 25 May 2012 11:25:44 GMT

Analogues

←Older revision		Revision as of 11:25, 25 May 2012
Line 98:		Line 98:
	The compounds of concern, which we're after, can be seen here:		The compounds of concern, which we're after, can be seen here:

-	[[Image:~~TriDesire1~~.png\|center]][[Image:~~DesiredTriaz2~~.png\|center]]	+	[[Image:TriazDesire1.png\|center]][[Image:TriazDesire22.png\|center]]
-	[[Image:~~DesiredTriaz3~~.png\|center]]	+	[[Image:TriazDesire3.png\|center]]

	===References===		===References===

	Yasuda, N.; Nagakura, T.; Yamazaki, K.; Yoshikawa, S.; Okuda, T.; Ikuta, H.; Koyanagi, M. ( Eisai Co., Ltd.). Preparation of N-carbamoylazoles as dipeptidyl peptidase IV inhibitors. European Patent 1 258 480 A1, 2002; SciFinder Scholar AN 2002:886010 (accessed 2/3/2012).		Yasuda, N.; Nagakura, T.; Yamazaki, K.; Yoshikawa, S.; Okuda, T.; Ikuta, H.; Koyanagi, M. ( Eisai Co., Ltd.). Preparation of N-carbamoylazoles as dipeptidyl peptidase IV inhibitors. European Patent 1 258 480 A1, 2002; SciFinder Scholar AN 2002:886010 (accessed 2/3/2012).

Jim Cronshaw: /* Analogues */

Jim Cronshaw — Wed, 23 May 2012 11:12:02 GMT

Analogues

←Older revision		Revision as of 11:12, 23 May 2012
Line 73:		Line 73:
	==Analogues==		==Analogues==

-	These are analogues of my series which we're interested in obtaining. If you're reading this and interested in donating to the cause, feel free to contact me.	+	These are analogues of my series which we're interested in obtaining. If you're reading this and interested in donating to the cause, feel free to contact me: [http://openwetware.org/wiki/User:Jim_Cronshaw Jim Cronshaw]

	Iain Wallace created a cytoscape file which details purchaseable compounds related to the two series that I am trying to make. The file can be found [http://malaria.ourexperiment.org/in_silico_prediction/2962/Purchaseable_chemical_space_around_TCMDC_135294_TCMDC_134395.html here], and Cytoscape can be downloaded for free [http://www.cytoscape.org/ here] (one will need to activate the chemviz plugin, which can be activated from within Cytoscape). The results of this work, in the form of a list of purchaseable compounds, can be found [http://www.emolecules.com/cgi-bin/rene/visitor.cgi?h=6e7ea189a97a2ba9e5ddefe7286381332dce72297e598f2a here]		Iain Wallace created a cytoscape file which details purchaseable compounds related to the two series that I am trying to make. The file can be found [http://malaria.ourexperiment.org/in_silico_prediction/2962/Purchaseable_chemical_space_around_TCMDC_135294_TCMDC_134395.html here], and Cytoscape can be downloaded for free [http://www.cytoscape.org/ here] (one will need to activate the chemviz plugin, which can be activated from within Cytoscape). The results of this work, in the form of a list of purchaseable compounds, can be found [http://www.emolecules.com/cgi-bin/rene/visitor.cgi?h=6e7ea189a97a2ba9e5ddefe7286381332dce72297e598f2a here]

Jim Cronshaw: /* Analogues */

Jim Cronshaw — Wed, 23 May 2012 11:11:11 GMT

Analogues

←Older revision		Revision as of 11:11, 23 May 2012
Line 72:		Line 72:

	==Analogues==		==Analogues==
		+
		+	These are analogues of my series which we're interested in obtaining. If you're reading this and interested in donating to the cause, feel free to contact me.

	Iain Wallace created a cytoscape file which details purchaseable compounds related to the two series that I am trying to make. The file can be found [http://malaria.ourexperiment.org/in_silico_prediction/2962/Purchaseable_chemical_space_around_TCMDC_135294_TCMDC_134395.html here], and Cytoscape can be downloaded for free [http://www.cytoscape.org/ here] (one will need to activate the chemviz plugin, which can be activated from within Cytoscape). The results of this work, in the form of a list of purchaseable compounds, can be found [http://www.emolecules.com/cgi-bin/rene/visitor.cgi?h=6e7ea189a97a2ba9e5ddefe7286381332dce72297e598f2a here]		Iain Wallace created a cytoscape file which details purchaseable compounds related to the two series that I am trying to make. The file can be found [http://malaria.ourexperiment.org/in_silico_prediction/2962/Purchaseable_chemical_space_around_TCMDC_135294_TCMDC_134395.html here], and Cytoscape can be downloaded for free [http://www.cytoscape.org/ here] (one will need to activate the chemviz plugin, which can be activated from within Cytoscape). The results of this work, in the form of a list of purchaseable compounds, can be found [http://www.emolecules.com/cgi-bin/rene/visitor.cgi?h=6e7ea189a97a2ba9e5ddefe7286381332dce72297e598f2a here]
Line 94:		Line 96:
	E157-8415		E157-8415

-	The compounds of concern can be ~~found~~ here:	+	The compounds of concern, which we're after, can be seen here:

	[[Image:TriDesire1.png\|center]][[Image:DesiredTriaz2.png\|center]]		[[Image:TriDesire1.png\|center]][[Image:DesiredTriaz2.png\|center]]

Jim Cronshaw: /* Analogues */

Jim Cronshaw — Wed, 23 May 2012 11:09:46 GMT

Analogues

←Older revision		Revision as of 11:09, 23 May 2012
Line 93:		Line 93:
	E157-8412		E157-8412
	E157-8415		E157-8415
		+
		+	The compounds of concern can be found here:
		+
		+	[[Image:TriDesire1.png\|center]][[Image:DesiredTriaz2.png\|center]]
		+	[[Image:DesiredTriaz3.png\|center]]

	===References===		===References===

	Yasuda, N.; Nagakura, T.; Yamazaki, K.; Yoshikawa, S.; Okuda, T.; Ikuta, H.; Koyanagi, M. ( Eisai Co., Ltd.). Preparation of N-carbamoylazoles as dipeptidyl peptidase IV inhibitors. European Patent 1 258 480 A1, 2002; SciFinder Scholar AN 2002:886010 (accessed 2/3/2012).		Yasuda, N.; Nagakura, T.; Yamazaki, K.; Yoshikawa, S.; Okuda, T.; Ikuta, H.; Koyanagi, M. ( Eisai Co., Ltd.). Preparation of N-carbamoylazoles as dipeptidyl peptidase IV inhibitors. European Patent 1 258 480 A1, 2002; SciFinder Scholar AN 2002:886010 (accessed 2/3/2012).

Jim Cronshaw: /* Analogues */

Jim Cronshaw — Tue, 22 May 2012 02:12:31 GMT

Analogues

←Older revision		Revision as of 02:12, 22 May 2012
Line 76:		Line 76:

	A list, in .csv format, of the above molecules can be found [http://openwetware.org/wiki/Image:Triazolourea_Table.csv here]. Listed are the identifiers of the above molecules in InChi, InChiKey, SMILES and eMolecules formats.		A list, in .csv format, of the above molecules can be found [http://openwetware.org/wiki/Image:Triazolourea_Table.csv here]. Listed are the identifiers of the above molecules in InChi, InChiKey, SMILES and eMolecules formats.
		+
		+	ChemDiv ID numbers, for future reference:
		+	G680-0512
		+	E157-8439
		+	E157-8431
		+	E157-8441
		+	E157-8446
		+	E157-5439
		+	E157-8413
		+	E157-8416
		+	E157-8423
		+	G404-0645
		+	E157-8442
		+	E157-8420
		+	E157-8408
		+	E157-8412
		+	E157-8415

	===References===		===References===

	Yasuda, N.; Nagakura, T.; Yamazaki, K.; Yoshikawa, S.; Okuda, T.; Ikuta, H.; Koyanagi, M. ( Eisai Co., Ltd.). Preparation of N-carbamoylazoles as dipeptidyl peptidase IV inhibitors. European Patent 1 258 480 A1, 2002; SciFinder Scholar AN 2002:886010 (accessed 2/3/2012).		Yasuda, N.; Nagakura, T.; Yamazaki, K.; Yoshikawa, S.; Okuda, T.; Ikuta, H.; Koyanagi, M. ( Eisai Co., Ltd.). Preparation of N-carbamoylazoles as dipeptidyl peptidase IV inhibitors. European Patent 1 258 480 A1, 2002; SciFinder Scholar AN 2002:886010 (accessed 2/3/2012).

Jim Cronshaw: /* Analogues */

Jim Cronshaw — Wed, 25 Apr 2012 08:32:08 GMT

Analogues

←Older revision		Revision as of 08:32, 25 April 2012
Line 74:		Line 74:

	Iain Wallace created a cytoscape file which details purchaseable compounds related to the two series that I am trying to make. The file can be found [http://malaria.ourexperiment.org/in_silico_prediction/2962/Purchaseable_chemical_space_around_TCMDC_135294_TCMDC_134395.html here], and Cytoscape can be downloaded for free [http://www.cytoscape.org/ here] (one will need to activate the chemviz plugin, which can be activated from within Cytoscape). The results of this work, in the form of a list of purchaseable compounds, can be found [http://www.emolecules.com/cgi-bin/rene/visitor.cgi?h=6e7ea189a97a2ba9e5ddefe7286381332dce72297e598f2a here]		Iain Wallace created a cytoscape file which details purchaseable compounds related to the two series that I am trying to make. The file can be found [http://malaria.ourexperiment.org/in_silico_prediction/2962/Purchaseable_chemical_space_around_TCMDC_135294_TCMDC_134395.html here], and Cytoscape can be downloaded for free [http://www.cytoscape.org/ here] (one will need to activate the chemviz plugin, which can be activated from within Cytoscape). The results of this work, in the form of a list of purchaseable compounds, can be found [http://www.emolecules.com/cgi-bin/rene/visitor.cgi?h=6e7ea189a97a2ba9e5ddefe7286381332dce72297e598f2a here]
		+
		+	A list, in .csv format, of the above molecules can be found [http://openwetware.org/wiki/Image:Triazolourea_Table.csv here]. Listed are the identifiers of the above molecules in InChi, InChiKey, SMILES and eMolecules formats.

	===References===		===References===

	Yasuda, N.; Nagakura, T.; Yamazaki, K.; Yoshikawa, S.; Okuda, T.; Ikuta, H.; Koyanagi, M. ( Eisai Co., Ltd.). Preparation of N-carbamoylazoles as dipeptidyl peptidase IV inhibitors. European Patent 1 258 480 A1, 2002; SciFinder Scholar AN 2002:886010 (accessed 2/3/2012).		Yasuda, N.; Nagakura, T.; Yamazaki, K.; Yoshikawa, S.; Okuda, T.; Ikuta, H.; Koyanagi, M. ( Eisai Co., Ltd.). Preparation of N-carbamoylazoles as dipeptidyl peptidase IV inhibitors. European Patent 1 258 480 A1, 2002; SciFinder Scholar AN 2002:886010 (accessed 2/3/2012).

Jim Cronshaw at 02:47, 24 April 2012

Jim Cronshaw — Tue, 24 Apr 2012 02:47:51 GMT

←Older revision		Revision as of 02:47, 24 April 2012
Line 1:		Line 1:
	{{OSDDMalaria}}		{{OSDDMalaria}}

-	==GSK Triazolourea Singleton==	+	=GSK Triazolourea Singleton=

	The triazolourea singleton has the following structure:		The triazolourea singleton has the following structure:
Line 14:		Line 14:
	InChI=1S/C12H14ClN5O3S/c1-16(2)12(19)18-8-14-11(15-18)22(20,21)17(3)10-6-4-9(13)5-7-10/h4-8H,1-3H3		InChI=1S/C12H14ClN5O3S/c1-16(2)12(19)18-8-14-11(15-18)22(20,21)17(3)10-6-4-9(13)5-7-10/h4-8H,1-3H3

-	===Synthesis===	+	==Synthesis==

	The proposed synthesis for this compound is below:		The proposed synthesis for this compound is below:
Line 70:		Line 70:

	----		----
		+
		+	==Analogues==
		+
		+	Iain Wallace created a cytoscape file which details purchaseable compounds related to the two series that I am trying to make. The file can be found [http://malaria.ourexperiment.org/in_silico_prediction/2962/Purchaseable_chemical_space_around_TCMDC_135294_TCMDC_134395.html here], and Cytoscape can be downloaded for free [http://www.cytoscape.org/ here] (one will need to activate the chemviz plugin, which can be activated from within Cytoscape). The results of this work, in the form of a list of purchaseable compounds, can be found [http://www.emolecules.com/cgi-bin/rene/visitor.cgi?h=6e7ea189a97a2ba9e5ddefe7286381332dce72297e598f2a here]

	===References===		===References===

	Yasuda, N.; Nagakura, T.; Yamazaki, K.; Yoshikawa, S.; Okuda, T.; Ikuta, H.; Koyanagi, M. ( Eisai Co., Ltd.). Preparation of N-carbamoylazoles as dipeptidyl peptidase IV inhibitors. European Patent 1 258 480 A1, 2002; SciFinder Scholar AN 2002:886010 (accessed 2/3/2012).		Yasuda, N.; Nagakura, T.; Yamazaki, K.; Yoshikawa, S.; Okuda, T.; Ikuta, H.; Koyanagi, M. ( Eisai Co., Ltd.). Preparation of N-carbamoylazoles as dipeptidyl peptidase IV inhibitors. European Patent 1 258 480 A1, 2002; SciFinder Scholar AN 2002:886010 (accessed 2/3/2012).

Matthew Todd: /* Methods of chlorine production */

Matthew Todd — Thu, 08 Mar 2012 09:46:09 GMT

Methods of chlorine production

←Older revision		Revision as of 09:46, 8 March 2012
Line 37:		Line 37:

	====Methods of chlorine production====		====Methods of chlorine production====
		+
		+	''(Any input on Cl<sub>2</sub> production gratefully received directly below (if you're a member of OWW) or at [https://plus.google.com/u/0/115975655197247500095/posts this G+ post] or on Twitter at @osddmalaria.''

	There are five methods of chlorine production available that I’m aware of. Guidance here has been provided by len1 at [http://www.sciencemadness.org/talk/viewthread.php?tid=9713 Sciencemadness]		There are five methods of chlorine production available that I’m aware of. Guidance here has been provided by len1 at [http://www.sciencemadness.org/talk/viewthread.php?tid=9713 Sciencemadness]

Matthew Todd: /* Alternatives to chlorine */

Matthew Todd — Thu, 08 Mar 2012 09:44:01 GMT

Alternatives to chlorine

←Older revision		Revision as of 09:44, 8 March 2012
Line 65:		Line 65:
	Let’s have a vote. I’m of the opinion that trying it with chlorine gas. Though dangerous, it would also be a lot of fun.		Let’s have a vote. I’m of the opinion that trying it with chlorine gas. Though dangerous, it would also be a lot of fun.

-	''To comment/advise'' try [https://plus.google.com/u/0/115975655197247500095/posts here on G+], or Tweet to @osddmalaria.	+	'''To comment/advise''' try [https://plus.google.com/u/0/115975655197247500095/posts here on G+], or Tweet to @osddmalaria.

	----		----