OSDDMalaria:Arylpyrazole Series - Revision history

Paul M. Ylioja: /* Synthesis */

Paul M. Ylioja — Thu, 05 Apr 2012 06:16:02 GMT

Synthesis

←Older revision		Revision as of 06:16, 5 April 2012
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	=== Synthesis ===		=== Synthesis ===

-	The core can be synthesised with [http://dx.doi.org/10.1002/jhet.5570240634 apparent ease] from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine. ELN entries [http://malaria.ourexperiment.org/uri/c0 PMY 43-1] [http://malaria.ourexperiment.org/uri/c4 PMY 44-1] for the core synthesis and hydrolysis respectively.	+	The core can be synthesised with [http://dx.doi.org/10.1002/jhet.5570240634 apparent ease] from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine. See ELN entries [http://malaria.ourexperiment.org/uri/c0 PMY 43-1] [http://malaria.ourexperiment.org/uri/c4 PMY 44-1] for the core synthesis and hydrolysis respectively.

	[[Image:PMY43-1.png\|thumb\|center\|450px\|Synthesis of pyrazole core]]		[[Image:PMY43-1.png\|thumb\|center\|450px\|Synthesis of pyrazole core]]

Paul M. Ylioja: /* Synthesis */ eln links

Paul M. Ylioja — Thu, 05 Apr 2012 06:01:11 GMT

Synthesis: eln links

←Older revision		Revision as of 06:01, 5 April 2012
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	=== Synthesis ===		=== Synthesis ===

-	The core can be synthesised with [http://dx.doi.org/10.1002/jhet.5570240634 apparent ease] from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine.	+	The core can be synthesised with [http://dx.doi.org/10.1002/jhet.5570240634 apparent ease] from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine. ELN entries [http://malaria.ourexperiment.org/uri/c0 PMY 43-1] [http://malaria.ourexperiment.org/uri/c4 PMY 44-1] for the core synthesis and hydrolysis respectively.

	[[Image:PMY43-1.png\|thumb\|center\|450px\|Synthesis of pyrazole core]]		[[Image:PMY43-1.png\|thumb\|center\|450px\|Synthesis of pyrazole core]]

Matthew Todd: /* Aryl Pyrazole Sub-series */

Matthew Todd — Sat, 24 Mar 2012 04:00:37 GMT

Aryl Pyrazole Sub-series

←Older revision		Revision as of 04:00, 24 March 2012
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	* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]		* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available (ABI Chem, AKos, Ambinter, Molport, Specs). Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available (ABI Chem, AKos, Ambinter, Molport, Specs). Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]
-	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4028326&loc=ec_rcs CID4028326]. Commercially available.	+	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4028326&loc=ec_rcs CID4028326]. Commercially available (ABI Chem, Ambinter, Chemfrog, Molport, Vitas-M, Zinc).
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=45589299&loc=ec_rcs CID45589299]. Limited commercial availability (AKos).		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=45589299&loc=ec_rcs CID45589299]. Limited commercial availability (AKos).
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46188955&loc=ec_rcs CID46188955]		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46188955&loc=ec_rcs CID46188955]

Matthew Todd: /* Aryl Pyrazole Sub-series */

Matthew Todd — Sat, 24 Mar 2012 03:57:55 GMT

Aryl Pyrazole Sub-series

←Older revision		Revision as of 03:57, 24 March 2012
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	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=372804&loc=ec_rcs CID372804]. Commercially available (ABI Chem).		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=372804&loc=ec_rcs CID372804]. Commercially available (ABI Chem).
	* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]		* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]
-	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]	+	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available (ABI Chem, AKos, Ambinter, Molport, Specs). Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4028326&loc=ec_rcs CID4028326]. Commercially available.		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4028326&loc=ec_rcs CID4028326]. Commercially available.
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=45589299&loc=ec_rcs CID45589299]. Limited commercial availability (AKos).		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=45589299&loc=ec_rcs CID45589299]. Limited commercial availability (AKos).

Matthew Todd: /* Aryl Pyrazole Sub-series */

Matthew Todd — Sat, 24 Mar 2012 03:56:00 GMT

Aryl Pyrazole Sub-series

←Older revision		Revision as of 03:56, 24 March 2012
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	Other compounds of interest from PubChem:<br>		Other compounds of interest from PubChem:<br>
-	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=372804&loc=ec_rcs CID372804]. Commercially available.	+	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=372804&loc=ec_rcs CID372804]. Commercially available (ABI Chem).
	* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]		* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]

Matthew Todd: /* Aryl Pyrazole Sub-series */

Matthew Todd — Sat, 24 Mar 2012 03:55:22 GMT

Aryl Pyrazole Sub-series

←Older revision		Revision as of 03:55, 24 March 2012
Line 19:		Line 19:
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4028326&loc=ec_rcs CID4028326]. Commercially available.		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4028326&loc=ec_rcs CID4028326]. Commercially available.
-	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=45589299&loc=ec_rcs CID45589299]. Limited commercial availability.	+	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=45589299&loc=ec_rcs CID45589299]. Limited commercial availability (AKos).
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46188955&loc=ec_rcs CID46188955]		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46188955&loc=ec_rcs CID46188955]
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15338085&loc=ec_rcs CID15338085]		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15338085&loc=ec_rcs CID15338085]

Matthew Todd: /* Aryl Pyrazole Sub-series */

Matthew Todd — Sat, 24 Mar 2012 03:53:35 GMT

Aryl Pyrazole Sub-series

←Older revision		Revision as of 03:53, 24 March 2012
Line 15:		Line 15:

	Other compounds of interest from PubChem:<br>		Other compounds of interest from PubChem:<br>
-	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=372804&loc=ec_rcs ~~372804~~]. ~~Comercially~~ available.	+	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=372804&loc=ec_rcs CID372804]. Commercially available.
	* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]		* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]

Matthew Todd: /* Aryl Pyrazole Sub-series */ added 372804

Matthew Todd — Sat, 24 Mar 2012 03:53:10 GMT

Aryl Pyrazole Sub-series: added 372804

←Older revision		Revision as of 03:53, 24 March 2012
Line 15:		Line 15:

	Other compounds of interest from PubChem:<br>		Other compounds of interest from PubChem:<br>
		+	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=372804&loc=ec_rcs 372804]. Comercially available.
	* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]		* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]

Matthew Todd: /* Aryl Pyrazole Sub-series */ added more pubchem compounds, from Chris Southan

Matthew Todd — Sat, 24 Mar 2012 03:45:19 GMT

Aryl Pyrazole Sub-series: added more pubchem compounds, from Chris Southan

←Older revision		Revision as of 03:45, 24 March 2012
Line 17:		Line 17:
	* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]		* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]
	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]		* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]
-		+	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4028326&loc=ec_rcs CID4028326]. Commercially available.
		+	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=45589299&loc=ec_rcs CID45589299]. Limited commercial availability.
		+	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46188955&loc=ec_rcs CID46188955]
		+	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15338085&loc=ec_rcs CID15338085]

	=== Synthesis ===		=== Synthesis ===

Matthew Todd: /* Aryl Pyrazole Sub-series */

Matthew Todd — Sat, 24 Mar 2012 03:40:47 GMT

Aryl Pyrazole Sub-series

←Older revision		Revision as of 03:40, 24 March 2012
Line 16:		Line 16:
	Other compounds of interest from PubChem:<br>		Other compounds of interest from PubChem:<br>
	* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]		* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]
-	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222] - been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]	+	* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]