OSDDMalaria:Arylpyrazole Series
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Aryl Pyrazole Sub-series
The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK arylpyrrole set.
ChEMBL-NTD has 18 hits in the TCAMS data set with an aryl pyrazole core. 14 with activity below 2 micromolar:
TCMDC-131674: pXC50 3D7 147.17nM ALogP 4.88/ACD LogP 4.552
Synthesis
Core: Synthesis