OSDDMalaria:Arylpyrazole Series

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m (Aryl Pyrazole Sub-series)
(Aryl Pyrazole Sub-series: added more pubchem compounds, from Chris Southan)
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* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]
* [http://www.ncbi.nlm.nih.gov/pccompound?term=11609708 CID11609708]
* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]
* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3568222&loc=ec_rcs CID3568222]. Commercially available. Has been assayed for antimalarial activity [http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=504832 AID504832], data submitted by [http://www.microbiology.columbia.edu/faculty/fidock.html David Fidock]
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* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4028326&loc=ec_rcs CID4028326]. Commercially available.
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* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=45589299&loc=ec_rcs CID45589299]. Limited commercial availability.
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* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46188955&loc=ec_rcs CID46188955]
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* [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15338085&loc=ec_rcs CID15338085]
=== Synthesis ===
=== Synthesis ===

Revision as of 23:45, 23 March 2012

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Aryl Pyrazole Sub-series

The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK arylpyrrole set.


ChEMBL-NTD TCAMS data set has 89 hits with aryl-pyrazole core; 18 hits with an 5-alkyl aryl pyrazole core; 14 with activity below 500 nanomolar:


Other compounds of interest from PubChem:

Synthesis

The core can be synthesised with apparent ease from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine.

Synthesis of pyrazole core
Synthesis of pyrazole core
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