OSDDMalaria:Arylpyrazole Series: Difference between revisions
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=== Synthesis === | === Synthesis === | ||
The core can be synthesised with [http://dx.doi.org/10.1002/jhet.5570240634 apparent ease] from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine. | |||
[[Image:PMY43-1.png|thumb|center|450px|Synthesis of pyrazole core]] | |||
Revision as of 22:24, 20 March 2012
Aryl Pyrazole Sub-series
The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK arylpyrrole set.
ChEMBL-NTD TCAMS data set has 89 hits with aryl-pyrazole core; 18 hits with an 5-alkyl aryl pyrazole core; 14 with activity below 500 nanomolar:
- TCMDC-131674: pXC50 3D7 147 nM ACD LogP 4.55
- TCMDC-123909: pXC50 3D7 234 nM ACD LogP 3.18
- TCMDC-124020: pXC50 3D7 253 nM ACD LogP 3.03
- TCMDC-124032: pXC50 3D7 258 nM ACD LogP 4.06
Synthesis
The core can be synthesised with apparent ease from ethylacetoacetate, DMF dimethyl acetal and phenylhydrazine.
