OSDDMalaria:Arylpyrazole Series

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The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK [[OSDDMalaria:GSK_Arylpyrrole_Series|arylpyrrole set]].
The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK [[OSDDMalaria:GSK_Arylpyrrole_Series|arylpyrrole set]].
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ChEMBL-NTD has 18 hits in the TCAMS data set with an aryl pyrazole core. 14 with activity below 2 micromolar:
 
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[https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/638119 TCMDC-131674]: pXC50 3D7 147.17nM ALogP 4.88/ACD LogP 4.552
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ChEMBL-NTD TCAMS data set has 89 hits with aryl-pyrazole core; 18 hits with an 5-alkyl aryl pyrazole core; 14 with activity below 500 nanomolar:
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* [https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/638119 TCMDC-131674]: pXC50 3D7 147 nM ACD LogP 4.55
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* [https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/636460 TCMDC-123909]: pXC50 3D7 234 nM ACD LogP 3.18
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* [https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/641812 TCMDC-124020]: pXC50 3D7 253 nM ACD LogP 3.03
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* [https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/640905 TCMDC-124032]: pXC50 3D7 258 nM ACD LogP 4.06

Revision as of 00:00, 21 March 2012

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Aryl Pyrazole Sub-series

The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK arylpyrrole set.


ChEMBL-NTD TCAMS data set has 89 hits with aryl-pyrazole core; 18 hits with an 5-alkyl aryl pyrazole core; 14 with activity below 500 nanomolar:


Synthesis

Core: Synthesis

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