OSDDMalaria:Arylpyrazole Series
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The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK [[OSDDMalaria:GSK_Arylpyrrole_Series|arylpyrrole set]]. | The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK [[OSDDMalaria:GSK_Arylpyrrole_Series|arylpyrrole set]]. | ||
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| - | [https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/638119 TCMDC-131674]: pXC50 3D7 147 | + | ChEMBL-NTD TCAMS data set has 89 hits with aryl-pyrazole core; 18 hits with an 5-alkyl aryl pyrazole core; 14 with activity below 500 nanomolar: |
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| + | * [https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/638119 TCMDC-131674]: pXC50 3D7 147 nM ACD LogP 4.55 | ||
| + | * [https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/636460 TCMDC-123909]: pXC50 3D7 234 nM ACD LogP 3.18 | ||
| + | * [https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/641812 TCMDC-124020]: pXC50 3D7 253 nM ACD LogP 3.03 | ||
| + | * [https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/640905 TCMDC-124032]: pXC50 3D7 258 nM ACD LogP 4.06 | ||
Revision as of 01:00, 21 March 2012
OSDD Home Malaria Home The Story So Far GSK Arylpyrrole Series GSK Triazolourea Singleton GSK Amino-thienopyrimidine Series Other GSK Series Under Consideration Links
Aryl Pyrazole Sub-series
The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK arylpyrrole set.
ChEMBL-NTD TCAMS data set has 89 hits with aryl-pyrazole core; 18 hits with an 5-alkyl aryl pyrazole core; 14 with activity below 500 nanomolar:
- TCMDC-131674: pXC50 3D7 147 nM ACD LogP 4.55
- TCMDC-123909: pXC50 3D7 234 nM ACD LogP 3.18
- TCMDC-124020: pXC50 3D7 253 nM ACD LogP 3.03
- TCMDC-124032: pXC50 3D7 258 nM ACD LogP 4.06
Synthesis
Core: Synthesis
