OSDDMalaria:Arylpyrazole Series

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The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK [[OSDDMalaria:GSK_Arylpyrrole_Series|arylpyrrole set]].
The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK [[OSDDMalaria:GSK_Arylpyrrole_Series|arylpyrrole set]].
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ChEMBL-NTD has 18 hits in the TCAMS data set with an aryl pyrazole core. 14 with activity below 2 micromolar:
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[https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/638119 TCMDC-131674]: pXC50 3D7 147.17nM ALogP 4.88/ACD LogP 4.552
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=== Synthesis ===
=== Synthesis ===
Core: [http://dx.doi.org/10.1002/jhet.5570240634 Synthesis]
Core: [http://dx.doi.org/10.1002/jhet.5570240634 Synthesis]

Revision as of 21:45, 20 March 2012

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Aryl Pyrazole Sub-series

The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK arylpyrrole set.

ChEMBL-NTD has 18 hits in the TCAMS data set with an aryl pyrazole core. 14 with activity below 2 micromolar:

TCMDC-131674: pXC50 3D7 147.17nM ALogP 4.88/ACD LogP 4.552


Synthesis

Core: Synthesis

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