OSDDMalaria:Arylpyrazole Series
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The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK [[OSDDMalaria:GSK_Arylpyrrole_Series|arylpyrrole set]]. | The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK [[OSDDMalaria:GSK_Arylpyrrole_Series|arylpyrrole set]]. | ||
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| + | ChEMBL-NTD has 18 hits in the TCAMS data set with an aryl pyrazole core. 14 with activity below 2 micromolar: | ||
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| + | [https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/638119 TCMDC-131674]: pXC50 3D7 147.17nM ALogP 4.88/ACD LogP 4.552 | ||
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=== Synthesis === | === Synthesis === | ||
Core: [http://dx.doi.org/10.1002/jhet.5570240634 Synthesis] | Core: [http://dx.doi.org/10.1002/jhet.5570240634 Synthesis] | ||
Revision as of 22:45, 20 March 2012
OSDD Home Malaria Home The Story So Far GSK Arylpyrrole Series GSK Triazolourea Singleton GSK Amino-thienopyrimidine Series Other GSK Series Under Consideration Links
Aryl Pyrazole Sub-series
The OSDDMalaria pyrazole series is derived from the OSDDMalaria GSK arylpyrrole set.
ChEMBL-NTD has 18 hits in the TCAMS data set with an aryl pyrazole core. 14 with activity below 2 micromolar:
TCMDC-131674: pXC50 3D7 147.17nM ALogP 4.88/ACD LogP 4.552
Synthesis
Core: Synthesis
