OHSU Knight Cancer Institute Research Groups:OCI Cancer Journal Club

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Equipped with his five senses, man explores the universe around him and calls the adventure Science.  ~Edwin Powell Hubble, The Nature of Science, 1954

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Contents

Objectives of the OHSU Cancer Biology Journal Club

Cross-departmental journal club composed of students, postdocs, fellows and clinical and basic science faculty with shared interest in basic principles, emerging discoveries, and new therapeutic approaches in Cancer Biology. The goals of the meetings are to:

  • Critically evaluate new cutting edge literature on mechanisms underlying the development and maintenance of cancer to inform the development of new therapeutics. Papers should be paradigm shifting and set a backdrop for discussion into therapeutics facilitated by the clinical attendees.
  • Provide students, postdocs and fellows with training and interactions with faculty interested in Cancer Biology and emerging therapeutics

KCI CJC Information

Want to join us? All are invited!

  • To get on the listserve:
go to the following web site:
http://mailman.ohsu.edu/cgi-bin/mailman/listinfo/oncobio
follow instructions for subscribing
  • To send out your paper
Send an e-mail to 'oncobioATohsu.edu' with your paper attached
  • When and where we meet
MacHall 2136
Thursdays noon-1 PM
Lunch provided by KCI
  • Organizer contact information:
Rosie Sears-searsr@ohsu.edu
Charlie Lopez- lopezc@ohsu.edu

Member Labs and Affiliations

Lopez Lab Hem Onc

Sears Lab

Hoatlin Lab

Thayer Lab

Wong Lab

Lloyd Lab CROET

McCullough Lab CROET

Schedule

  • Scheduling In Progress
Date Presenters Topic Links & Comments
9/79/2012 Rosalie Sears Organization
10/4/2012 Brittany Allen-Petersen
10/13/2011 Xiaoli Zhang Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway–dependent and PI3K pathway–independent mechanisms PI3KCA mechanisms
10/20/2011 Rosie Sears Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis Goetz 2009
10/27/2011 Katy Van Hook Competative RNA Karreth (2011)
11/3/2011 Mushui Dai A Critical Role for Noncoding 5S rRNA in Regulating Mdmx Stability. Mol Cell. 2011 Sep 16;43(6):1023-32. http://www.sciencedirect.com/science/article/pii/S109727651100640X
11/10/2011 Charlie Lopez CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans science 2011 Beatty
11/17/2011 canceled
11/24/2011 xxxxxxxxxx THANKSGIVING, NO JOURNAL CLUB xxxxxxxxxx
12/1/2011 Aaron Wortham The Eph-Receptor A7 is a Soluble Tumor Suppressor for Follicular Lymphoma Oricchio E et al 2011 Cell
12/8/2011 Myron Peto
12/15/2011 Chuck Pham Jr Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells http://www.mendeley.com/research/efficient-delivery-liposomemediated-mgmtsirna-reinforces-cytotoxity-temozolomide-gbminitiating-cells/
1/5/2012 Tim Butler
1/12/2012 Jared Fischer Single-molecule transcript counting of stem-cell markers in the mouse intestine. http://www.nature.com/ncb/journal/v14/n1/full/ncb2384.html
1/19/2012 Yulong Su The Metabolic Regulator ERRa, a Downstream Target of HER2/IGF-1R, as a Therapeutic Target in Breast Cancer. http://www.cell.com/cancer-cell/abstract/S1535-6108(11)00318-7
1/26/2012 Yuangang Liu An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor Opitz C et al 2011 Nature
2/2/2012 Mahnaz Janghorban
2/9/2012 Tiffany DeVine
2/16/2012 Jason Link
2/23/2012 Ellen Langer
3/1/2012 Aaron Jacobs BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance http://www.sciencedirect.com/science/article/pii/S1535610811004387
3/8/2012 Vince Bicocca TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers [1]
3/15/2012 Gordon Shore, Ph.D. Regulation of cell death by the Bcl-2 family member Mcl-1 Vollum seminar, M1441
3/22/2012 John Oyer Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia [2]
4/5/2012
4/12/2012 Stacey Lin The translational landscape of mTOR signalling steers cancer initiation and metastasis http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10912.html
4/19/2012 Juan Liang Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer Duncan (2012)
4/26/2012 Jeff Wu Metastasis of tumor cells is enhanced by downregulation of Bit1.

PLoS One.

[3]
5/3/2012 Arthur Edwards bone metastasis in breast cancer through NOTCH signaling with clinical implications in NOTCH directed therapies [4]
5/10/2012 Xiaoxin Sun A SUMOylation-Dependent Transcriptional Subprogram is Required for Myc-Driven Tumorigenesis [5]
5/17/2012 Nathalie Javidi-Sharifi Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance [6]
5/24/2012 Nichole Owen Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma [7]
5/31/2012 Zhiping Wang Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism [8]
6/7/2012 Kishore Challagundla Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase [9] [10]
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