OHSU Knight Cancer Institute Research Groups:OCI Cancer Journal Club

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Objectives of the OHSU Cancer Biology Journal Club

Cross-departmental journal club composed of students, postdocs, fellows and clinical and basic science faculty with shared interest in basic principles, emerging discoveries, and new therapeutic approaches in Cancer Biology. The goals of the meetings are to:

• Critically evaluate new cutting edge literature on mechanisms underlying the development and maintenance of cancer to inform the development of new therapeutics. Papers should be paradigm shifting and set a backdrop for discussion into therapeutics facilitated by the clinical attendees.
• Provide students, postdocs and fellows with training and interactions with faculty interested in Cancer Biology and emerging therapeutics

KCI CJC Information

Want to join us? All are invited!

• To get on the listserve:

go to the following web site:

http://mailman.ohsu.edu/cgi-bin/mailman/listinfo/oncobio

follow instructions for subscribing

• To send out your paper

Send an e-mail to 'oncobioATohsu.edu' with your paper attached

• When and where we meet

MacHall 2136

Thursdays noon-1 PM

Lunch provided by KCI

• Organizer contact information:

Rosie Sears-searsr@ohsu.edu

Charlie Lopez- lopezc@ohsu.edu

Member Labs and Affiliations

Lopez Lab Hem Onc

Sears Lab

Hoatlin Lab

Thayer Lab

Wong Lab

Lloyd Lab CROET

McCullough Lab CROET

Schedule

• Scheduling In Progress

Date	Presenters	Topic	Links & Comments
10/1/2013		Organization
10/8/2013
10/15/2013
10/22/2013
10/29/2013
11/5/2013
11/12/2013
11/19/2013
11/26/2013
12/3/2013
12/10/2013
12/17/2013
12/24/2013	Canceled
12/31/2013
1/7/2014
1/14/2014
2/14/2013	Tiffany Devine	The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites	[1]
2/21/2013	Ellie Juarez	Poly(beta-aminoester) nanoparticle-delivery of p53 has activity against small cell lung cancer in vitro and in vivo Molecular Cancer Therapeutics	[2]
2/28/2013	Tim Butler	tumor heterogeneity, focusing mostly on a recent science paper (Kreso 2013) which shows serially passages clones responding differently to chemotherapy	Kreso 2013Gerlinger 2012
3/7/2013	Toni West	Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties	Schwitalla S et al Cell 152, 25-38 (2013)
3/14/2013	Jared Fischer	Intestinal label-retaining cells are secretory precursors expressing Lgr5	[3]
3/21/2013	Mushui Dai	Splicing-Factor Oncoprotein SRSF1 Stabilizes p53 via RPL5 and Induces Cellular Senescence.	[4]
4/4/2013	Nathalie Javidi-Sharifi	Tumor Stem Cells Generate Vasculature	[5] [6]
4/11/2013	Amy Farrell	Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer	Stefan Eser, et al
4/18/2013	Trevor Levin	DNA damage foci formation around double strand breaks and regulation of NHEJ and HR repair mechanisms	ZimmermanVirgilioKukas
4/25/2013	Kevin Watanabe-Smith	"Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models"	[7] [8]
5/2/2013	Stacey Lin	Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion	[9]
5/9/2013	Juan Liang	Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53	[10]
5/16/201	Xiaoxin Sun	Restoring p53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-Phosphorylated Nuclear iASPP	[11]
5/23/2013	Dr. Charles Lopez	CANCELED DUE TO RESEARCH WEEK
5/30/2013	Mahnaz Janghorban	Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer	Dong et al
6/6/2013	Marcus Calkins	The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation	[12]