OHSU Knight Cancer Institute Research Groups:OCI Cancer Journal Club: Difference between revisions

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|10/4/2012
|10/4/2012
|Brittany Allen-Petersen
|Brittany Allen-Petersen
|
|Tumourmicro-environment elicits innate resistance to RAF inhibitors through HGF secretion
|
|[http://www.nature.com/nature/journal/v487/n7408/full/nature11183.html Straussman et al]
|--
|--
|10/11/2012
|10/11/2012
|
|Ellen Langer
|
|A restricted cell population propagates glioblastoma growth after chemotherapy
|
|[http://openwetware.org/images/3/3a/Chen_Nature_2012.pdf Chen, et al] Additional vivo detection papers [http://www.ncbi.nlm.nih.gov/pubmed/22854777 1] [http://www.ncbi.nlm.nih.gov/pubmed/22855427 2]
|--
|--
|10/18/2012
|10/18/2012
|
|Yulong Su
|
|Transcriptional Amplification in Tumor Cells with Elevated c-Myc;
|  
c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells
|[http://www.sciencedirect.com/science/article/pii/S0092867412010574 Lin 2012]
[http://www.sciencedirect.com/science/article/pii/S0092867412011014 Nie 2012]
|--
|--
|10/25/2012
|10/25/2012
|
|****CANCELLED****  Dr. Charles Lopez
|  
| Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
|
|[http://openwetware.org/images/a/a5/Nature11156.pdf Misale at. al] [http://openwetware.org/images/3/33/Nature11156-s1.pdf supp. info]
|--  
|--  
|11/1/2012
|11/1/2012
|
|Asia Mitchell
|
|Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks
|
|[http://www.sciencedirect.com/science/article/pii/S0092867412004199]
|--
|--
|11/8/2012
|11/8/2012
|
|Yuhan Wang
|
|"Loss of 5-Hydroxymethylcytosine is an Epigenetic Hallmark of Melanoma"
|
|[http://openwetware.org/images/4/4e/Journal_Club_paper-5hmc.pdf]
|--
|--
|11/17/2011
|11/15/2012
|canceled
|Tyler Risom
|  
|Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
|
| [http://openwetware.org/images/8/85/PI3K_and_Parp_1.full.pdf Ashish et. al.] [http://openwetware.org/images/8/82/PI3K_and_Parp_2.full.pdf Yasir et al]
|--
|--
|11/24/2011
|11/22/2012
|xxxxxxxxxx
|xxxxxxxxxx
|THANKSGIVING, NO JOURNAL CLUB
|THANKSGIVING, NO JOURNAL CLUB
|xxxxxxxxxx
|xxxxxxxxxx
|--
|--
|12/1/2011
|11/29/2012
|Aaron Wortham
|Dr. Swarnali Acharyya, a CDB/Knight faculty candidate seminar
|The Eph-Receptor A7 is a Soluble Tumor Suppressor for Follicular Lymphoma
|
|[http://openwetware.org/wiki/Image:EPHA7_and_FL.pdf Oricchio E et al 2011 Cell]
|--
|12/8/2011
|Myron Peto
|
|
|
|--
|--
|12/15/2011
|12/6/2012
|Chuck Pham Jr
|Marilynn Chow
|Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells
|Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression
|http://www.mendeley.com/research/efficient-delivery-liposomemediated-mgmtsirna-reinforces-cytotoxity-temozolomide-gbminitiating-cells/
|[http://openwetware.org/images/1/1d/2012_Oncogene_Pagliuca_et_al.pdf Pagliuca et al] [http://openwetware.org/images/3/3f/2012_Oncogene_Pagliuca_et_al_Supp.pdf supplement]
|--
|--
|1/5/2012
|1/10/2013
|Tim Butler
|Lilli Welch
|
|
|
|
|--
|--
|1/12/2012
|1/17/2013
|Jared Fischer
|Spencer Watson
|Single-molecule transcript counting of stem-cell markers in the mouse intestine.
|Mitochondrial dynamics regulates migration and invasion of breast cancer cells
|http://www.nature.com/ncb/journal/v14/n1/full/ncb2384.html
|[http://openwetware.org/images/4/4b/Onc2012494a.pdf]
|--
|1/24/2013
|Ping Wang
|Oncogenic Kras-Induced GM-CSF Projection Promotes the Development of Pancreatic Neoplasia
|[http://www.ncbi.nlm.nih.gov/pubmed/22698407] [http://www.ncbi.nlm.nih.gov/pubmed/22698406]
|--
|1/31/2013
|Aaron Wortham
|Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
|[http://openwetware.org/images/5/51/Luga_V_et_al_Cell_2012.pdf Luga V et al Cell 151, 1542-1556 (2012)]
|--
|2/7/2013
|Jeff Wu
|MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrinsubunits
| [http://www.nature.com/ncb/journal/v14/n6/pdf/ncb2491.pdf]
|--
|--
|1/19/2012
|2/14/2013
|Yulong Su
|Tiffany Devine
|The Metabolic Regulator ERRa, a Downstream Target of HER2/IGF-1R, as a Therapeutic Target in Breast Cancer.
|The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites
|http://www.cell.com/cancer-cell/abstract/S1535-6108(11)00318-7
|[http://openwetware.org/images/3/3c/Gao_Cell_2012_BMP_inhibitor_coco_reactivates_BCC_at_lung_met_sites.pdf]
|--
|--
|1/26/2012
|2/21/2013
|Yuangang Liu
|Ellie Juarez
|An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
|Poly(beta-aminoester) nanoparticle-delivery of p53 has activity against small cell lung cancer in vitro and in vivo Molecular Cancer Therapeutics
|[http://openwetware.org/images/a/a3/Opitz_C_et_al_2011_Nature.pdf Opitz C et al 2011 Nature]
|[http://openwetware.org/images/b/bd/Gene_Therapy_JC_and_class.pdf]
|--
|--
|2/2/2012
|2/28/2013
|Mahnaz Janghorban
|Tim Butler
|
|
|
|
|--
|--
|2/9/2012
|3/7/2013
|Tiffany DeVine
|Toni West
|Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties
|[http://openwetware.org/images/c/c3/Schwitalla_S_et_al_Cell_152%2C_25-38_%282013%29.pdf Schwitalla S et al Cell 152, 25-38 (2013)]
|--
|3/14/2013
|Jared Fischer
|
|
|
|
|--
|--
|2/16/2012
|3/21/2013
|Jason Link
|Mushui Dai
|
|
|
|
|--
|--
|2/23/2012
|4/4/2013
|Ellen Langer
|Nathalie Javidi-Sharifi
|
|
|
|
|--
|--
|3/1/2012
|4/11/2013
|Aaron Jacobs
|Amy Farrell
|BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance
|
|http://www.sciencedirect.com/science/article/pii/S1535610811004387
|
|--
|--
|3/8/2012
|4/18/2013
|Vince Bicocca
|Trevor Levin
|TAK1 Inhibition Promotes Apoptosis in KRAS-Dependent Colon Cancers
|
|[http://www.cell.com/abstract/S0092-8674%2812%2900102-X?script=true]
|
|--
|3/15/2012
|Gordon Shore, Ph.D.
|Regulation of cell death by the Bcl-2 family member Mcl-1
|Vollum seminar, M1441
|--
|3/22/2012
|John Oyer
|Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
|[http://openwetware.org/images/9/9d/Nature_2011_Dawson.pdf]
|--
|--
|4/5/2012
|4/25/2013
|
|Kevin Watanabe-Smith
|
|
|
|
|--
|--
|4/12/2012
|5/2/2013
|Stacey Lin
|Stacey Lin
|The translational landscape of mTOR signalling steers cancer initiation and metastasis
|
|http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10912.html
|
|--
|--
|4/19/2012
|5/9/2013
|Juan Liang
|Juan Liang
|Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
|
|[http://openwetware.org/images/3/30/2012_cell_Dynamic_Reprogramming_of_the_Kinome_in_Response_to_Targeted_MEK_Inhibition_in_Triple-Negative_Breast_Cancer.pdf Duncan (2012)]
|
|--
|4/26/2012
|Jeff Wu
|Metastasis of tumor cells is enhanced by downregulation of Bit1.
PLoS One.
|[http://openwetware.org/images/8/89/Karmali_bit1_PLosOne2011.pdf]
|--
|--
|5/3/2012
|5/16/201
|Arthur Edwards
|bone metastasis in breast cancer through NOTCH signaling with clinical implications in NOTCH directed therapies
|[http://www.cell.com/cancer-cell/abstract/S1535-6108(10)00531-3?switch=standard]
|--
|5/10/2012
|Xiaoxin Sun
|Xiaoxin Sun
|A SUMOylation-Dependent Transcriptional Subprogram is Required for Myc-Driven Tumorigenesis
|
|[http://openwetware.org/images/8/86/Journal_club_paper.pdf]
|
|--
|--
|5/17/2012
|5/23/2013
|Nathalie Javidi-Sharifi
|Dr. Charles Lopez
|Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance
|
|[http://www.cell.com/cancer-cell/abstract/S1535-6108(12)00079-7?switch=standard]
|
|--
|--
|5/24/2012
|5/30/2013
|Nichole Owen
|Mahnaz Janghorban
|Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
|
|[http://www.sciencedirect.com/science/article/pii/S1535610812000396]
|
|--
|--
|5/31/2012
|6/6/2013
|Zhiping Wang
|Marcus Calkins
|Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
|
|[http://www.sciencedirect.com/science/article/pii/S0092867412003522]
|
|--
|6/7/2012
|Kishore Challagundla
|Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase
|[http://openwetware.org/images/4/40/2012-Mol_Cell-Negative_regulation_of_tumor_supressor_function_of_FBW7gama_by_PIN1-pdf.pdf] [http://openwetware.org/images/7/74/2012-Mol_Cell-FBW7_gamma_and_PIN1-Supp_Info.pdf]
|}
|}
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Revision as of 09:04, 19 February 2013

Equipped with his five senses, man explores the universe around him and calls the adventure Science. ~Edwin Powell Hubble, The Nature of Science, 1954

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Objectives of the OHSU Cancer Biology Journal Club

Cross-departmental journal club composed of students, postdocs, fellows and clinical and basic science faculty with shared interest in basic principles, emerging discoveries, and new therapeutic approaches in Cancer Biology. The goals of the meetings are to:

  • Critically evaluate new cutting edge literature on mechanisms underlying the development and maintenance of cancer to inform the development of new therapeutics. Papers should be paradigm shifting and set a backdrop for discussion into therapeutics facilitated by the clinical attendees.
  • Provide students, postdocs and fellows with training and interactions with faculty interested in Cancer Biology and emerging therapeutics

KCI CJC Information

Want to join us? All are invited!

  • To get on the listserve:
go to the following web site:
http://mailman.ohsu.edu/cgi-bin/mailman/listinfo/oncobio
follow instructions for subscribing
  • To send out your paper
Send an e-mail to 'oncobioATohsu.edu' with your paper attached
  • When and where we meet
MacHall 2136
Thursdays noon-1 PM
Lunch provided by KCI
  • Organizer contact information:
Rosie Sears-searsr@ohsu.edu
Charlie Lopez- lopezc@ohsu.edu

Member Labs and Affiliations

Lopez Lab Hem Onc

Sears Lab

Hoatlin Lab

Thayer Lab

Wong Lab

Lloyd Lab CROET

McCullough Lab CROET

Schedule

  • Scheduling In Progress
Date Presenters Topic Links & Comments
9/27/2012 Rosalie Sears Organization
10/4/2012 Brittany Allen-Petersen Tumourmicro-environment elicits innate resistance to RAF inhibitors through HGF secretion Straussman et al
10/11/2012 Ellen Langer A restricted cell population propagates glioblastoma growth after chemotherapy Chen, et al Additional vivo detection papers 1 2
10/18/2012 Yulong Su Transcriptional Amplification in Tumor Cells with Elevated c-Myc;

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

Lin 2012

Nie 2012

10/25/2012 ****CANCELLED**** Dr. Charles Lopez Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer Misale at. al supp. info
11/1/2012 Asia Mitchell Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks [1]
11/8/2012 Yuhan Wang "Loss of 5-Hydroxymethylcytosine is an Epigenetic Hallmark of Melanoma" [2]
11/15/2012 Tyler Risom Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer Ashish et. al. Yasir et al
11/22/2012 xxxxxxxxxx THANKSGIVING, NO JOURNAL CLUB xxxxxxxxxx
11/29/2012 Dr. Swarnali Acharyya, a CDB/Knight faculty candidate seminar
12/6/2012 Marilynn Chow Analysis of the combined action of miR-143 and miR-145 on oncogenic pathways in colorectal cancer cells reveals a coordinate program of gene repression Pagliuca et al supplement
1/10/2013 Lilli Welch
1/17/2013 Spencer Watson Mitochondrial dynamics regulates migration and invasion of breast cancer cells [3]
1/24/2013 Ping Wang Oncogenic Kras-Induced GM-CSF Projection Promotes the Development of Pancreatic Neoplasia [4] [5]
1/31/2013 Aaron Wortham Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration Luga V et al Cell 151, 1542-1556 (2012)
2/7/2013 Jeff Wu MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrinsubunits [6]
2/14/2013 Tiffany Devine The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites [7]
2/21/2013 Ellie Juarez Poly(beta-aminoester) nanoparticle-delivery of p53 has activity against small cell lung cancer in vitro and in vivo Molecular Cancer Therapeutics [8]
2/28/2013 Tim Butler
3/7/2013 Toni West Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties Schwitalla S et al Cell 152, 25-38 (2013)
3/14/2013 Jared Fischer
3/21/2013 Mushui Dai
4/4/2013 Nathalie Javidi-Sharifi
4/11/2013 Amy Farrell
4/18/2013 Trevor Levin
4/25/2013 Kevin Watanabe-Smith
5/2/2013 Stacey Lin
5/9/2013 Juan Liang
5/16/201 Xiaoxin Sun
5/23/2013 Dr. Charles Lopez
5/30/2013 Mahnaz Janghorban
6/6/2013 Marcus Calkins
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