OHSU Knight CI Genomic Instability Interest Group

Member Labs and Affiliations

Hoatlin Lab Biochemistry and Molecular Biology (BMB)

Thayer Lab BMB

Lu Lab BMB

Lloyd Lab Center for Research on Occupational and Environmental Toxicology (CROET)

Liskay Lab Molecular and Medical Genetics (MMG)

McCullough Lab CROET & MMG

Grompe Lab MMG

Turker Lab CROET

Schedule

Time & Location

DNA Tuesdays! The meetings will be held in MRB 634, typically on the first and last Tuesdays of the month at 9AM. This way, nearly every week will have "DNA Tuesday". For those of you who are new, the second Tuesday is when the Fanconi anemia program project team meets, and the third Tuesday is reserved for the DNA repair videoconference for the DNA Repair Interest Group at NIH. NIH videoconference is held in the CROET 2nd floor conference room (BSAC 2501M).

Coming Soon (please add your guests and seminars of interest to the DNA R3 Club schedule below for planning, or email Maureen [hoatlinm AT ohsu dot edu] with details)

• Dr. Patrick Sung- September 18. Host: Amanda McCullough (CROET)
• Dr. Karlene Cimprich- TBA. Host: Maureen Hoatlin (BMB)

Previous Talks

2006

May 16th: Guest speaker Dr. Junjie Chen from the Mayo Clinic College of Medicine "DNA damage checkpoints and tumorigenesis" Host: Hua Lu (BMB)

May 2: Guest speaker Dr. Rachel Klevit University of Washington, Seattle "Structural and Functional Insights into the BRCA1/BARD1 Ubiquitin Ligase" Host: M. Hoatlin (BMB)

April 24th and 25th: Guest speaker Dr. Mark Kelley Wells Center for Pediatric Research, Indiana University School of Medicine "Going Ape over Ref-1; Translation Implications of the DNA Repair Enzyme Ape1/Ref1 as a DNA Repair and Redox Target" Co-Hosts: M. Hoatlin (BMB) & A. McCullough (MMG)

April 4th: Stephen Lloyd. CROET, "Base excision repair of DNA damaged by reactive oxygen Species"

March 28th: Alex Sobeck (BMB, Hoatlin Lab) will cover highlights of a newly-recognized component of the BLM helicase complex called BLAP75. BLM is a member of the recQ family of 3'-5' DNA helicases, which includes five human homologues (RECQL, BLM, WRN, RECQ4, and RECQ5). Loss-of-function mutations in BLM, WRN, and RECQ4 give rise to Bloom's syndrome (BS), Werner's syndrome (WS), and Rothmund-Thomson syndrome (RTS)....all are cancer susceptibility disorders. Fascinating stuff, and, by the way, Alex co-discovered BLAP75 with Weidong's lab.

March 15th: Extra Meeting. Please join the weekly lab meeting of the Hoatlin Lab (MRB 634 at 1:30-3PM) for the review of the highlights of the Cancer Susceptibility Special Conference by Maureen Hoatlin. Warning: Pictures of DNA repair luminaries in skimpy bathing suits might be displayed.

March 7th: Guest speaker Dr. Stephen Kowalczykowski from the University of California, Davis "Recombinational DNA Repair: Visualization at the Single-Molecule Level" Host: M. Hoatlin (BMB)

February 28th: Stacie Stone (Hoatlin Lab, BMB) will give perspectives and background in preparation for the visit of Stephen Kowalczykowski (UC Davis). Dr. Kowalczykowski’s lab has made major contributions to understanding how certain dual DNA helicases unwind duplex DNA, motoring with great speed along antiparallel tracks.

February 7th: Henri Van de Vrugt (Grompe Lab, MMG) will lead the discussion on assessing new insights and perspectives about the connection between the BACH1 helicase and BRCA1 in the Fanconi Pathway.

February 3rd: Our first speaker this year will be Julie Bailis, PhD from the Salk Institute. The title is "The DNA damage response during replication." This talk will be at a special time, Friday February 3 at 2PM in MRB 634. I have attached 3 review articles suggested by Julie that I hope will prepare you for the type of lively and interactive discussion we have enjoyed in our past meetings. Related papers will be emailed in a timely fashion for the following sessions. Host: M. Hoatlin (BMB)

External Meetings of Interest

1. August 9-13, 2006 Salk DNA Replication and Genome Integrity--Matt Thayer and Dan Pankratz are going
2. Sept 12-16 2006 11th Annual Xenopus Conference, Kazusa City, Japan
3. January 17-22 2007 Genome Instability and Repair Meeting Breckenridge, Colorado

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