Nijman lab
Ce-M-M-
The Nijman lab is the latest addition to CeMM. CeMM is a novel, international, independent and interdisciplinary research Center in Molecular Medicine of the Austrian Academy of Sciences. “From the clinic to the clinic”: Driven by medical needs, CeMM integrates basic research and clinical expertise to pursue innovative diagnostic and therapeutic approaches focused on cancer, inflammation and immune disorders. At the center of CeMM’s interest are patients and associated diseases. CeMM’s mission is to combine insight obtained from basic and clinical research and use it to implement the development of innovative therapeutic and diagnostic strategies – from the clinic to the clinic. Located at the Vienna General Hospital (AKH), Austria’s largest medical research complex, CeMM functions as bidirectional channel between basic research and clinical applications. CeMM provides access to post-genomic technologies for the biomedical community and is a training and teaching center for a new generation of researchers in molecular medicine. CeMM’s innovative approaches are based on a novel, post-genomic, molecular understanding of biological and pathological systems.The goal of CeMM is to assist in preparing the predictive, preventive and personalized medicine of the future.
Research scope
Within the Nijman lab the aim is to produce high quality and conceptual science that contributes to the fundamental understanding of the cellular circuitry in health and disease with a particular focus on cancer. In order to achieve this, the lab employs state-of-the-art technology, genomics and bioinformatics.
Projects
Synthetic lethal interactions in mammalian cells
During the last 5 years, in vitro human cell genetics has become within reach for many laboratories around the world. One of the challenges for the coming years is to use the available tools in new and creative ways to fully exploit the power of experimental genetics. A major focus of the lab is the high-throughput assessment of synthetic lethal interactions using chemical compounds and RNAi
Cell circuits and cancer
Side projects are generally focussed on cancer-relevant pathways and signaling dynamics, such as ubiquitination/deubiquitination
Collaborations
Collaborations are crucial for modern day science!
Listed here are (science) friends and collaborators:
Tony Huang lab(NYU)
Thijn Brummelkamp lab(MIT, Whitehead Institute)
Rene Bernards lab(Netherlands Cancer Institute)
Todd Golub lab (Broad Institute, MIT/Harvard)
Dave Root (Broad Institute, MIT/Harvard)
