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| <div style="padding: 10px; color: #ffffff; background-color: #000; width: 730px">
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| [[Nijman lab:Contact | <font face="trebuchet ms" style="color:#ffffff"> '''Contact''' </font>]]
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| [[Nijman lab:Positions | <font face="trebuchet ms" style="color:#ffffff"> '''Positions''' </font>]]
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| [[Nijman lab:Lab Members | <font face="trebuchet ms" style="color:#ffffff"> '''Lab Members''' </font>]]
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| [[Nijman lab:Publications | <font face="trebuchet ms" style="color:#ffffff"> '''Publications''' </font>]]
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| [[Nijman lab:Links | <font face="trebuchet ms" style="color:#ffffff"> '''Links''' </font>]]
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| [[Category:Nijman lab]]
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| ==Ce-M-M-==
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| [[Image:Logo CeMM 3.gif|left|400px|Logo CeMM 3.gif]] The Nijman lab is the latest addition to [http://www.cemm.oeaw.ac.at/ CeMM]. CeMM is a novel, international, independent and interdisciplinary research Center in Molecular Medicine of the Austrian Academy of Sciences. “From the clinic to the clinic”: Driven by medical needs, CeMM integrates basic research and clinical expertise to pursue innovative diagnostic and therapeutic approaches focused on cancer, inflammation and immune disorders. At the center of CeMM’s interest are patients and associated diseases. CeMM’s mission is to combine insight obtained from basic and clinical research and use it to implement the development of innovative therapeutic and diagnostic strategies – from the clinic to the clinic. Located at the [http://en.wikipedia.org/wiki/Vienna_General_Hospital Vienna General Hospital] (AKH), Austria’s largest medical research complex, CeMM functions as bidirectional channel between basic research and clinical applications. CeMM provides access to post-genomic technologies for the biomedical community and is a training and teaching center for a new generation of researchers in molecular medicine. CeMM’s innovative approaches are based on a novel, post-genomic, molecular understanding of biological and pathological systems.The goal of CeMM is to assist in preparing the predictive, preventive and personalized medicine of the future.
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| ==Research scope==
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| Within the Nijman lab the aim is to produce high quality and conceptual science that contributes to the fundamental understanding of the cellular circuitry in health and disease with a particular focus on cancer. In order to achieve this, the lab employs state-of-the-art technology, genomics and bioinformatics.
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| ==Projects==
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| ===Synthetic lethal interactions in mammalian cells===
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| [[Image:Quote1.png|500px|right]] During the last 5 years, in vitro human cell genetics has become within reach for many laboratories around the world. One of the challenges for the coming years is to use the available tools in new and creative ways to fully exploit the power of experimental genetics. In this context, a major focus of the lab is the high-throughput assessment of [[synthetic lethality|synthetic lethal]] interactions using chemical compounds and [http://en.wikipedia.org/wiki/Rnai RNAi]. In particular we are trying to identify genotype-specific cancer vulnerabilites or <nowiki>"</nowiki>[http://en.wikipedia.org/wiki/Achilles%27_heel Achilles' heels"].
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| ===Cell circuits and cancer===
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| Side projects are generally focussed on cancer-relevant pathways and signaling dynamics, such as [http://en.wikipedia.org/wiki/Ubiquitination ubiquitination]/deubiquitination
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| ==Collaborations==
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| Collaborations are crucial for modern day science!
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| Listed here are some (science) friends and collaborators:
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| [http://www.med.nyu.edu/people/huangt03.html Tony Huang](NYU)
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| [http://www.wi.mit.edu/research/fellows/brummelkamp.html Thijn Brummelkamp](MIT, Whitehead Institute)
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| [http://www.biomedicalgenetics.nl/Members/Bernards/bernards.html Rene Bernards](Netherlands Cancer Institute)
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| [http://www.broad.mit.edu/about/bios/bio-golub.html Todd Golub] (Broad Institute, MIT/Harvard)
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| [http://www.broad.mit.edu/about/bios/bio-root.html Dave Root] (Broad Institute, MIT/Harvard)
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