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| - | <div style="padding: 10px; color: #ffffff; background-color: #000; width: 730px">
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| - | <center>
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| - | [[Nijman| <font face="trebuchet ms" style="color:#ffffff"> '''Take me back''' </font>]]
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| - | </center>
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| - | </div><br>
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| - | ==This century==
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| - | Selected publications:
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| - | Muellner MK, Uras IZ, Gapp BV, Kerzendorfer C, Smida M, Lechtermann H, Craig-Mueller N, Colinge J, Duernberger G, Nijman SM. A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer. Nat Chem Biol. 2011 Sep 25;7(11) [http://www.ncbi.nlm.nih.gov/pubmed/21946274]
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| - | Nijman SM. Synthetic lethality: General principles, utility and detection using genetic screens in human cells. FEBS Lett. 2010 Nov 19 [http://www.ncbi.nlm.nih.gov/pubmed/21094158 Pubmed]
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| - | Muellner MK, Nijman SM. Giving Rho(d) Directions. Nat Chem Biol. 2010 Jun;6(6):397-8 [http://www.ncbi.nlm.nih.gov/pubmed/20479746 Pubmed]
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| - | Perne P, Muellner MK, Steinrueck M, Craig-Mueller N, Mayerhofer J, Schwarzinger I, Sloane M, Uras IZ, Hoermann G, Nijman SMB, Mayerhofer M. Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis. PLoS ONE 4(12): e8292. doi:10.1371/journal.pone.0008292 [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008292 Free access]
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| - | Hoshida Y, Nijman SM, Kobayashi M, Chan JA, Brunet JP, Chiang DY, Villanueva A, Newell P, Ikeda K, Hashimoto M, Watanabe G, Gabriel S, Friedman SL, Kumada H, Llovet JM, Golub TR. Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. Cancer Res. 2009 Sep 15;69(18):7385-92. [http://www.ncbi.nlm.nih.gov/pubmed/19723656?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1 Pubmed]
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| - | Nijman SM, Hijmans EM, El Messaoudi S, van Dongen MM, Sardet C, Bernards R. A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta. ''J Biol Chem''. 2006 Aug 4;281(31):21582-7. [http://www.jbc.org/cgi/content/full/281/31/21582 Free access]
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| - | Oosterkamp HM, Neering H, Nijman SM, Dirac AM, Mooi WJ, Bernards R, Brummelkamp TR. An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis. ''Br J Dermatol''. 2006 Jul;155(1):182-5. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16792771&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Pubmed]
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| - | Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W, Gygi SP, Ploegh HL, Bernards R, D'Andrea AD. Regulation of monoubiquitinated PCNA by DUB autocleavage. ''Nat Cell Biol.'' 2006 Apr;8(4):339-47. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16531995&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Pubmed]
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| - | Nijman SM, Luna-Vargas MP, Velds A, Brummelkamp TR, Dirac AM, Sixma TK, Bernards R. A genomic and functional inventory of deubiquitinating enzymes.
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| - | ''Cell.'' 2005 Dec 2;123(5):773-86. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16325574&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Pubmed]
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| - | Dirac AM, Nijman SM, Brummelkamp TR, Bernards R. Functional annotation of deubiquitinating enzymes using RNA interference. ''Methods Enzymol.'' 2005;398:554-67. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16275358&ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Pubmed]
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| - | Nijman SM, Huang TT, Dirac AM, Brummelkamp TR, Kerkhoven RM, D'Andrea AD, Bernards R.
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| - | The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. ''Mol Cell.'' 2005 Feb 4;17(3):331-9. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=15694335&ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Pubmed]
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| - | Brummelkamp TR, Nijman SM, Dirac AM, Bernards R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. ''Nature.'' 2003 Aug 14;424(6950):797-801. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=12917690&ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Pubmed]
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| - | ==Last century==
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| - | De Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. ''Nature''. 1998 Dec 3;396(6710):474-7. [http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=9853756&ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Pubmed]
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