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The Nachury Lab is interested in using a combination of interdisciplinary approaches encompassing protein biochemistry, cell biology, in vitro assays, digital microscopy and mammalian cell engineering to study the molecular etiology of complex hereditary human diseases.
Our lab is part of the department of Molecular and Cellular Physiology and Stanford University School of Medicine.
A major focus of the lab is the study of the primary cilium, a once-obscure cellular organelle that has been "re-discovered" for its role in a number of signaling pathways (Hedgehog, Planar Cell Polarity,..). Most fascinatingly, defects in cilium biogenesis lead to a variety of symptoms such as retinal degeneration, kidney cysts, obesity, polydactyly, randomization of left-right asymmetry, etc.
