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| [[Image:CellCover4.jpg|thumb|300px|right|Bardet-Biedl Syndrome (BBS): a disease of the cilium.<br> BBS patients suffer from retinal degeneration (upper left), kidney malformations (lower right), obesity and polydactyly (upper right). The BBSome, a core complex of BBS proteins, coordinates vesicular transport to the primary cilium (lower left).]]
| | The openwetware wiki is no longer maintained. Our current website can be found at [http://nachurylab.weebly.com] |
| The Nachury Lab is part of the department of [http://mcp.stanford.edu/ Molecular and Cellular Physiology] at [http://med.stanford.edu/ Stanford University School of Medicine].<br>Our lab is interested in using a combination of interdisciplinary approaches encompassing protein biochemistry, cell biology, in vitro assays, digital microscopy and mammalian cell engineering to study the molecular etiology of complex hereditary human diseases.<br>
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| A major focus of the lab is the study of the primary cilium, a once-obscure cellular organelle that has recently been "re-discovered" for its role in a number of signaling pathways (Hedgehog, Planar Cell Polarity, PDGF,..). Most fascinatingly, molecular defects in cilium biogenesis lead to a variety of hereditary disorders (so-called "ciliopathies") characterized by retinal degeneration, kidney cysts, brain malformations, obesity, polydactyly, randomization of left-right asymmetry, etc. Our major goal is to characterize these ciliopathies at the molecular and cellular levels using state-of-the art proteomics and microscopy.
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Latest revision as of 18:06, 10 February 2016
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The openwetware wiki is no longer maintained. Our current website can be found at [1]
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