Nachury
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 BBS patients suffer from a variety of symptoms including obesity and polydactyly (upper right). Recently, we discovered that a core complex of BBS proteins (the BBSome) coordinates vesicular transport to the primary cilium (lower left). We study the primary cilium, a surface-exposed organelle required for vision, olfaction and developmental signaling and whose dysfunction leads to obesity, skeletal malformations and kidney cysts. To decode the fundamental principles of ciliary trafficking and to understand how trafficking shapes signaling at the primary cilium, we leverage a broad expertise in biochemistry, proteomics, cell biology and in vitro reconstitution.
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