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[[Image:Mukhopadhyay_Pump.jpg‎ |thumb|220px|right|Efflux Pumps provide a direct mechanism to alleviate product toxicity (Image prepared by [http://www.jbei.org/management/people2.shtml Everett Kaplan] (JBEI))]]
 
<font face="calibri" size="+1" style="color:#000000">Welcome to the Mukhopadhyay Group page!!
<font face="calibri" size="+1" style="color:#000000">'''Welcome to the Mukhopadhyay Group page'''!!
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[[Image:JBEI pumpkin 2015.png |thumb|220px|right|]]We are an interdisciplinary team at [http://www.lbl.gov/ Berkeley Lab] studying both engineered and environmental microbes. We are the Host Engineering group at [http://www.jbei.org/ JBEI], and we adopt targeted and systems biology approaches to elucidate causes of inhibition during fuel and chemicals production in microbial systems such as ''Escherichia coli'' and ''Saccharomyces cerevisiae''. We focus on engineering robust hosts for metabolite production, and we develop strategies that are universally useful, for microbial host engineering. We also engineer microbes towards catabolism of environmental pollutants,  where we address bioremediation of hydrocarbons, organophosphate and phosphonate compounds. We are part of the [http://enigma.lbl.gov/ ENIGMA] project where we take comprehensive systems biology approaches to examine bacterial signaling in ubiquitous and environmentally important, sulfate and metal reducing bacteria. We also study rainfall events and signaling in the fabulous cyanobacteria that dominate the desert soil crusts on our planet.
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[http://openwetware.org/wiki/User:Aindrila_Mukhopadhyay About Aindrila]
 
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== '''GROUP NEWS!!''' ==
 
=== Jan 20th 2015===
[[Image:Mingardon et al 3.png|thumb|300px|left| The Total efflux pump team: Angelique, Melissa, Florence, Aindrila and Camille (..only missing Kat and Eric)]] Flo's paper is out in [http://onlinelibrary.wiley.com/doi/10.1002/bit.25511/pdf Biotechnology and Bioengineering] A heroic effort in generating an improved pump for a volatile organic compound. We will look to the metabolic engineering community for a hexene production strain to implement this discovery.
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We are an interdisciplinary team at the [http://www.lbl.gov/ Berkeley Lab] studying signaling and stress response in both environmental and engineered organisms. We are part of the [http://enigma.lbl.gov/ ENIGMA] project where our research includes the study of two component signaling in the model sulfate reducing bacterium ''Desulfovibrio vulgaris'' Hildenborough. As part of the [http://jbei.org/index.html Joint BioEnergy Institute] we adopt targeted and systems biology approaches to elucidate causes of inhibition during fuel/ solvent production from lignocellulose using the host microbes such as ''Escherichia coli'' and ''Saccharomyces cerevisiae''. We hope to engineer better hosts for metabolite production and develop tools that are universally useful for microbial cellular engineering. Recently we have also become interested in studying signaling and response in cyanobacteria that dominate desert soil crusts.
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More about [http://openwetware.org/wiki/User:Aindrila_Mukhopadhyay Aindrila]
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== '''GROUP NEWS!!''' ==
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=== Nov 4th 2014===
[[Image:Jensen and foo et al.jpg|thumb|300px|right|Jensen, Foo et al 2014 gets a nice [http://newscenter.lbl.gov/2014/10/27/boosting-biogasoline-production-in-microbes/ write up] by Lynn Yarris and was featured on the front page of our DOE webpage!]] We published our study on improving Isopentenol tolerance and production in the [http://mbio.asm.org/content/5/6/e01932-14 mBio journal]. mBio featured it in their [http://mbioblog.asm.org/mbiosphere/2014/11/tolerance-engineering-boosts-production-of-biogasoline-in-bacteria.html blog]. We have gotten many more mentions ([http://www.rdmag.com/news/2014/10/boosting-biogasoline-production-microbes RDmag], [http://www.sciencedaily.com/releases/2014/11/141105122058.htm Science Daily], [http://www.greencarcongress.com/2014/10/20141027-jbei.html#comments Green car congress]...). Congratulations to Heather, Jee Loon and the rest of the team!!
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=== Feb 26th 2014===
[[Image:QUEST CAREER SPOTLIGHT.png|thumb|300px|left|KQED QUEST Career spotlight [http://www.youtube.com/watch?v=DMXHbi6XBQw video]]]
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=== June 6th 2013===
=== June 6th 2013===
[[Image:Rajeev et al 2013 Figure 1.jpg|thumb|300px|right|Lara's Microcoleus Desert soil crust paper in online in the [http://www.nature.com/ismej/journal/vaop/ncurrent/full/ismej201383a.html ISME Journal]!]] And we get a wonderful article in [http://newscenter.lbl.gov/feature-stories/2013/06/14/biological-soil-crust-secrets-uncovered TABL] by Lynn Yarris.
[[Image:Rajeev et al 2013 Figure 1.jpg|thumb|300px|right|Lara's Microcoleus Desert soil crust paper in online in the [http://www.nature.com/ismej/journal/vaop/ncurrent/full/ismej201383a.html ISME Journal]!]] And we get a wonderful article in [http://newscenter.lbl.gov/feature-stories/2013/06/14/biological-soil-crust-secrets-uncovered TABL] by [http://www.lynnyarris.com/ Lynn Yarris].
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We receive funding from:


[[Image:Doe-bioenergy-research-cent.jpg|75px|http://genomicscience.energy.gov/centers/]]
[[Image:Doe-bioenergy-research-cent.jpg|75px|http://genomicscience.energy.gov/centers/]]
[[Image:LBNL-Logo-Full.png|75px|http://www.lbl.gov]]
[[Image:LBNL-Logo-Full.png|75px|http://www.lbl.gov]]
[[Image:ENIGMA_logo.jpg|75px|http://enigma.lbl.gov/ENIGMA]]
[[Image:ENIGMA_logo.jpg|75px|http://enigma.lbl.gov/ENIGMA]]
[[Image:Index.jpg|75px]]
[[Image:Total.jpg|75px]]
[[Image:Total.jpg|75px]]
[[Image:Qb3 logo-PMS-660.jpg|75px]]


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Revision as of 22:21, 10 March 2015

About us            Contact            People            Research            Pubs etc            Internal           


Welcome to the Mukhopadhyay Group page!!

We are an interdisciplinary team at Berkeley Lab studying both engineered and environmental microbes. We are the Host Engineering group at JBEI, and we adopt targeted and systems biology approaches to elucidate causes of inhibition during fuel and chemicals production in microbial systems such as Escherichia coli and Saccharomyces cerevisiae. We focus on engineering robust hosts for metabolite production, and we develop strategies that are universally useful, for microbial host engineering. We also engineer microbes towards catabolism of environmental pollutants, where we address bioremediation of hydrocarbons, organophosphate and phosphonate compounds. We are part of the ENIGMA project where we take comprehensive systems biology approaches to examine bacterial signaling in ubiquitous and environmentally important, sulfate and metal reducing bacteria. We also study rainfall events and signaling in the fabulous cyanobacteria that dominate the desert soil crusts on our planet.


About Aindrila


GROUP NEWS!!

Jan 20th 2015

The Total efflux pump team: Angelique, Melissa, Florence, Aindrila and Camille (..only missing Kat and Eric)
Flo's paper is out in Biotechnology and Bioengineering A heroic effort in generating an improved pump for a volatile organic compound. We will look to the metabolic engineering community for a hexene production strain to implement this discovery.










Nov 4th 2014

Jensen, Foo et al 2014 gets a nice write up by Lynn Yarris and was featured on the front page of our DOE webpage!
We published our study on improving Isopentenol tolerance and production in the mBio journal. mBio featured it in their blog. We have gotten many more mentions (RDmag, Science Daily, Green car congress...). Congratulations to Heather, Jee Loon and the rest of the team!!









Feb 26th 2014

KQED QUEST Career spotlight video











June 6th 2013

Lara's Microcoleus Desert soil crust paper in online in the ISME Journal!
And we get a wonderful article in TABL by Lynn Yarris.















May 13th 2013

We get a chance to talk about our research at the Berkeley Rep at the Science at the theater organised by Friends of the Berkeley Lab!















March 19th 2013

women at energy
We get a mention in the Department Of Energy feature on STEM profiles.













Oct 1st 2012

Left to Right: Kavya, Melissa, Nhat-Tan, Lara, Marijke, Camille, Florence, Jee-Loon, Aindrila, Eric, Heather, Zain and Amanda
The whole group at the Can't Fail cafe. We have new members in the group - Amanda Reider Appel and Nhat Than Vuong!














Feb 14th 2012

Science Today, a UC Berkeley Radio channel, features comments on our study of the D. vulgaris two component system regulator network.









Nov 9th 2011

Lara and Eric's Response Regulator Map paper gets written about in Berkeley Lab's TABL site.











Oct 15th 2011

(Lara at the Soil crust display at the Berkeley Lab open house)
Lara and Eric's D. vulgaris Response Regulator map paper is out in Genome Biology.










Sept 27th 2011

(Photo by Roy Kaltschmidt, Berkeley Lab)
Mario (in the blue lab coat!!) features in the Berkeley Lab news letter TABL for his important contribution in developing Bisabolene production in yeast. Here is a link to Pamela and TaekSoon's Nature Communications paper










August 22nd 2011

Zain, Heather and Aindrila feature on the cover of the Biorefining magazine. Here is the article.










July 1st 2011

Our efflux pump paper gets a mention in the Microbe magazine. Other mentions of our study are in eureka alert, techblog, science daily, microbeworld, Materials Today to list a few!!!






We receive funding from:

http://genomicscience.energy.gov/centers/ http://www.lbl.gov http://enigma.lbl.gov/ENIGMA


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