Min-Ho Kim Lab:Research

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<h3>Overview</h3>
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<h3>Research goal</h3>
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<font size=3>The major research interest in our laboratory focuses on the development of novel therapeutics to promote the resolution of non-healing chronic wounds. The research goal of our laboratory is to (1) understand the molecular and cellular mechanisms by which local inflammatory environmental cues alter phenotypic switch of tissue infiltrating innate immune cells and these cells functionally interact with endogenous or exogenously implanted mesenchymal stem cells (MSCs), and (2) develop selective strategy to engineer microenvironmental cues towards tissue regeneration by utilizing micro/nano-engineered biomaterials that enable spatio-temporal control inflammatory response. To achieve this goal, we combine interdisciplinary approaches of immuno-biology, stem cell biology, cellular and tissue engineering, and nano-bioengineering.</font>
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<font size=3>The research goal of our laboratory is to (1) understand the molecular and cellular mechanisms by which local inflammatory environmental cues alter phenotypic switch of tissue infiltrating innate immune cells and these cells functionally interact with endogenous or exogenously implanted mesenchymal stem cells (MSCs), and (2) develop selective strategy to engineer microenvironmental cues towards tissue regeneration by utilizing micro/nano-engineered biomaterials that enable spatio-temporal control inflammatory response. To achieve this goal, we combine interdisciplinary approaches of immuno-biology, stem cell biology, cellular and tissue engineering, and nano-bioengineering.</font>

Revision as of 19:27, 18 June 2013

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Research goal

The research goal of our laboratory is to (1) understand the molecular and cellular mechanisms by which local inflammatory environmental cues alter phenotypic switch of tissue infiltrating innate immune cells and these cells functionally interact with endogenous or exogenously implanted mesenchymal stem cells (MSCs), and (2) develop selective strategy to engineer microenvironmental cues towards tissue regeneration by utilizing micro/nano-engineered biomaterials that enable spatio-temporal control inflammatory response. To achieve this goal, we combine interdisciplinary approaches of immuno-biology, stem cell biology, cellular and tissue engineering, and nano-bioengineering.


Current Research Projects

  1. Macrophage polarization on therapeutic potential of mesenchymal stem cells (MSCs).
  2. Targeted magnetic nanoparticle thermotherapy for the resolution of biofilm infection in diabetic wounds.
  3. Magnetically responsive injectable microgels for on-demand drug delivery and stem cell engineering.
  4. Nanoengineered biomaterial scaffold for immunomodulation.

Research Support

  • Farris Family Innovation Award
  • Kent State Postdoc Seed Program Award
  • Kent State Start-up Fund

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