My name is Maureen Hoatlin, and I'm currently at Oregon Health and Science University in Portland, Oregon. My lab joined OpenWetWare in 2006. We use OWW almost every day for our lab website, sharing our reagents and protocols, and organizing courses and seminars series. You can email me through OpenWetWare or contact me by:
We are interested in understanding how cells maintain genomic stability. One of the mechanisms that regulates this critical process is defective in Fanconi anemia (FA), a genetic model for human susceptibility to cancer. FA is a rare but devastating multi-gene disease thought to have an underlying defect in DNA interstrand crosslink repair.
Our lab pioneered the use of cell-free assays for FA proteins in extracts from Xenopus eggs. These extracts allow analysis of FA protein function and post-translational modifications in a context that is permissive for naturally-regulated DNA synthesis. The recruitment of Fanconi proteins to chromatin in S-phase is providing us with a biochemical platform for elucidating the molecular function of the Fanconi proteins during the DNA damage response.
OWW Links and Pages in Progress
Medical Students, here are your movies:
More Early Factoids, in chronological order, with some fun links