Levi T. Morran: Difference between revisions

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I am currently a postdoc in the [http://sites.bio.indiana.edu/~livelylab/ Lively lab] at Indiana University.
I am currently an NIH NRSA postdoc in the [http://sites.bio.indiana.edu/~livelylab/ Lively lab] at Indiana University.


Email me if you would like a full version of my CV.
Please email me if you would like a full version of my CV.


==Education==
==Education==
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I am broadly interested in factors that either facilitate or constrain '''adaptive evolution'''. Currently I am exploring the roles that mating systems and coevolutionary dynamics play in adaptive evolution.  
I am broadly interested in factors that either facilitate or constrain '''adaptive evolution'''. Currently I am exploring the roles that mating systems and coevolutionary dynamics play in adaptive evolution.  


I utilize [http://en.wikipedia.org/wiki/Experimental_evolution '''experimental evolution'''] to directly test hypotheses and determine the manner in which evolution proceeds by characterizing both the phenotypic and genetic changes that occur in evolving populations.
I utilize [http://en.wikipedia.org/wiki/Experimental_evolution '''experimental evolution'''] to directly test hypotheses and determine the manner in which evolution proceeds by characterizing both the phenotypic and genotypic changes that occur in evolving populations.


* '''MATING SYSTEM EVOLUTION'''
* '''MATING SYSTEM EVOLUTION'''
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I primarily work with the nematode ''Caenorhabditis elegans'' to study mating systems because this species utilizes two different mating strategies, outcrossing and self-fertilization.  
I primarily work with the nematode ''Caenorhabditis elegans'' to study mating systems because this species utilizes two different mating strategies, outcrossing and self-fertilization.  
'''Current Projects''':
- ''Genetics of Parallel Evolution in Experimentally Evolved Outcrossing Populations'': In a previous experimental evolution project, I exposed several obligate outcrossing ''C. elegans'' populations to a bacterial pathogen, ''Serratia marcescens''. Each population evolved the same defensive response to ''Serratia marcescens'' despite the fact that each population started the experiment with a different genetic background. I am currently working to determine the genetic basis of adaptation and parallel evolution of the behavioral response that arose in each population.
- ''Maintenance of Male-Specific Genes and Phenotypes in Selfing and Outcrossing Populations'': ''C. elegans'' maintains males at very low frequencies in most strains (male facilitate outcrossing, therefore outcrossing is rare in these strains). Theoretical work suggests that ''C. elegans'' naturally maintains males at frequencies sufficient to maintain male-specific genes through selection, and therefore preserve the male phenotype from mutation accumulation. I am using long-term experimental evolution to determine the consequences of maintaining males at low frequencies. I plan to measure the rate and magnitude of molecular and phenotypic change in male-specific genes and traits within populations that maintain males at different frequencies (ranging from obligate selfing to obligate outcrossing).


* '''COEVOLUTIONARY DYNAMICS'''
* '''COEVOLUTIONARY DYNAMICS'''
Coevolution accounts for a significant proportion of the evolutionary change that occurs in nature. This is quite reasonable because most, if not all, species live as members of communities composed of many species. As a result of interactions between members in a community, many species utilize not only their own genome, but also the genome of other species to facilitate survival and reproduction in context of mutualistic interactions. Conversely, antagonistic interactions between species are capable of driving rapid evolutionary change between interacting species. Thus intergenomic interactions, resulting from both mutualistic and antagonistic coevolution, play a major role in shaping the evolutionary trajectory of many species. I am interested in learning how coevolutionary interactions affect each interacting species, and also understanding the role that mating systems play in determining the outcome of coevolutionary interactions.
Coevolution accounts for a significant proportion of the evolutionary change that occurs in nature. This is quite reasonable because most, if not all, species live as members of communities composed of many species. As a result of interactions between members in a community, many species utilize not only their own genome, but also the genome of other species to facilitate survival and reproduction in context of mutualistic interactions. Conversely, antagonistic interactions between species are capable of driving rapid evolutionary change between interacting species. Thus intergenomic interactions, resulting from both mutualistic and antagonistic coevolution, play a major role in shaping the evolutionary trajectory of many species. I am interested in learning how coevolutionary interactions affect each interacting species, and also understanding the role that mating systems play in determining the outcome of coevolutionary interactions.


'''Current Projects''':
I am working with ''C. elegans'' and the bacterial pathogen, ''Serratia marcescens'', to study antagonistic coevolution. I am also working with the nematode ''Steinernema carpocapsae'' and its bacterial symbiont, ''Xenorhabdus nematophila'', to study mutualistic coevolution.
 
-'''Antagonistic coevolution'''
- ''Experimental Coevolution Test of the Red Queen'': This project combines my interests in both mating system evolution and coevolutionary dynamics! The Red Queen Hypothesis predicts that selective pressure from coevolving parasites can select for increased sexual reproduction (or outcrossing) in host populations because sex (or outcrossing) can produce offspring with rare genotypes that may avoid infection. I am using the nematode ''C. elegans'', along with several components of the ''C. elegans'' genetic tool-kit, to experimentally test Red Queen Hypothesis predictions, as they pertain to outcrossing and self-fertilization, via experimental coevolution with the virulent bacterial pathogen ''Serratia marcescens''.
 
-'''Mutualistic coevolution'''
- ''Empirical Tests and Genomic Analysis of the Constraints Imposed by Coevolution Within a Mutualism'': The mutualistic relationship between the nematode, ''Steinernema carpocapsae'', and its symbiotic bacteria, ''Xenorhabdus nematophila'', provides a rich experimental context for testing coevolutionary hypotheses. The two symbiotic partners operate in conjunction to infect a wide range of insect hosts. Although the nematode and bacterium share a very close mutualistic relationship, each can be maintained separately in the laboratory. This aspect of the system permits the deconstruction of the relationship and the opportunity to study the evolutionary constraints of an intimate mutualistic relationship. In this system suites of genes in both mutualist species facilitate interactions between both species and can ultimately determine the collective fitness of the pair. Thus, the genetic basis of these crucial emergent traits exhibited by the species pair is partitioned across the species barrier. This distribution of correlated genes between separate species may limit the adaptive potential and alter the evolutionary trajectory of the symbiotic relationship and/or each species separately. I am using experimental evolution in this system to determine the effect of coevolution within a mutualism on adaptation rates in ''X. nematophila'' either maintained within or independent of its nematode symbiont.


==Collaborators==
==Collaborators==
*[http://www.uoregon.edu/~pphil/ Jennifer Anderson, University of Oregon, Phillips Lab]
*[http://people.biology.ufl.edu/cbaer/Baer_lab/Home.html Charlie Baer, University of Florida]
*[http://www.indiana.edu/~bioweb/faculty/directory/profile.php?person=fbasheyv Farrah Bashey-Visser, Indiana University]
*[http://www.indiana.edu/~bioweb/faculty/directory/profile.php?person=fbasheyv Farrah Bashey-Visser, Indiana University]
*[http://sites.bio.indiana.edu/~moylelab/labmembers.html Dean Castillo, Indiana University, Moyle Lab]
*[http://sites.bio.indiana.edu/~delphlab/ Lynda Delph, Indiana University]
*[http://sites.bio.indiana.edu/~delphlab/ Lynda Delph, Indiana University]
*[http://www.bact.wisc.edu/faculty.php?init=HGB Heidi Goodrich-Blair, University of Wisconsin-Madison]
*[http://www.bact.wisc.edu/faculty.php?init=HGB Heidi Goodrich-Blair, University of Wisconsin-Madison]
*[http://sites.bio.indiana.edu/~hahnlab/ Matt Hahn, Indiana University]
*[http://www.indiana.edu/~curtweb/ Curt Lively, Indiana University]
*[http://www.indiana.edu/~curtweb/ Curt Lively, Indiana University]
*[http://www.uoregon.edu/~pphil/ Michelle Parmenter, University of Oregon, Phillips Lab]
*[http://www.uoregon.edu/~pphil/ Patrick Phillips, University of Oregon]
*[http://www.uoregon.edu/~pphil/ Patrick Phillips, University of Oregon]


==Publications==
==Publications==


# Morran, L.T., O.G. Schmidt, I.A. Gelarden, R.C. Parrish II, C.M. Lively. 2011. Running with the Red Queen: Host-parasite coevolution selects for bi-parental sex. Science. Jul 8; 333 (6039): 216-8.
# Morran, L.T., A. Ohdera, and P.C. Phillips. 2010. Purging deleterious mutations under self-fertilization: Paradoxical recovery in fitness with increasing mutation rate in Caenorhabditis elegans. PLoS ONE. 5(12): e14473. doi: 10.1371/journal.pone.0014473
# Morran, L.T., A. Ohdera, and P.C. Phillips. 2010. Purging deleterious mutations under self-fertilization: Paradoxical recovery in fitness with increasing mutation rate in Caenorhabditis elegans. PLoS ONE. 5(12): e14473. doi: 10.1371/journal.pone.0014473
# Anderson JL, Morran LT, Phillips PC. 2010. Outcrossing and the maintenance of males within C. elegans populations. J Hered. Mar-Apr;101 Suppl 1:S62-74.
# Anderson J.L., Morran L.T., Phillips P.C. 2010. Outcrossing and the maintenance of males within C. elegans populations. J Hered. Mar-Apr; 101 Suppl 1: S62-74.
# Morran LT, Parmenter MD, Phillips PC. 2009. Mutation load and rapid adaptation favour outcrossing over self-fertilization. Nature. Nov 19;462(7271):350-2.
# Morran L.T., Parmenter M.D., Phillips P.C. 2009. Mutation load and rapid adaptation favour outcrossing over self-fertilization. Nature. Nov 19; 462 (7271): 350-2.
# Morran LT, Cappy BJ, Anderson JL, Phillips PC. 2009. Sexual partners for the stressed: facultative outcrossing in the self-fertilizing nematode Caenorhabditis elegans. Evolution. Jun;63(6):1473-82.   
# Morran L.T., Cappy B.J., Anderson J.L., Phillips P.C. 2009. Sexual partners for the stressed: facultative outcrossing in the self-fertilizing nematode Caenorhabditis elegans. Evolution. Jun; 63 (6): 1473-82.   
# Bashey, F., L.T. Morran, and C.M. Lively.  2007.  Coinfection, kin selection, and the rate of host exploitation by a parasitic nematode.  Evolutionary Ecology Research 9: 947-958.
# Bashey, F., L.T. Morran, and C.M. Lively.  2007.  Coinfection, kin selection, and the rate of host exploitation by a parasitic nematode.  Evolutionary Ecology Research 9: 947-958.


==Research in News and Media Coverage==
==Research in News and Media Coverage==
'''Running with the Red Queen:'''
[http://www.ncbi.nlm.nih.gov/pubmed/21737728 Science Perspectives, Brockhurst, MA. 2011 Evolution: Sex, death, and the Red Queen.]
[http://www.bbc.co.uk/news/science-environment-14046316 BBC News]
[http://www.npr.org/2011/07/07/137681962/have-sex-to-stay-one-evolutionary-step-ahead NPR]
[http://www.washingtonpost.com/blogs/federal-eye/post/sex-matters-says-team-of-indiana-university-biologists/2011/03/23/gIQA0ngcBI_blog.html The Washington Post]
[http://blogs.discovermagazine.com/loom/2011/07/07/why-is-there-sex-to-fight-the-parasite-army/ Discover]
[http://www.livescience.com/14946-parasite-infection-sex.html LiveScience]
[http://gawker.com/5819692/scientists-figure-out-the-point-of-sex Gawker]
[http://newswatch.nationalgeographic.com/2011/07/11/birds-do-it-bees-do-it-but-why/ National Geographic News Watch]


'''Purging deleterious mutations under self-fertilization:'''  
'''Purging deleterious mutations under self-fertilization:'''  
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'''Mutation load and rapid adaptation favour outcrossing over self-fertilization:'''  
'''Mutation load and rapid adaptation favour outcrossing over self-fertilization:'''  


[http://f1000biology.com/article/id/1221956 Faculty of 1000 review]
[http://f1000.com/1221956 Faculty of 1000 review]


[http://www.ncbi.nlm.nih.gov/pubmed/19924202 News and Views, Agrawal, AF. 2009 Evolutionary biology: Why reproduction often takes two.]
[http://www.ncbi.nlm.nih.gov/pubmed/19924202 News and Views, Agrawal, AF. 2009 Evolutionary biology: Why reproduction often takes two.]
[http://comm.uoregon.edu/archive/news-release/2009/10/why-sex-partner-better University of Oregon news release]


[http://www.oregonlive.com/news/index.ssf/2009/10/the_laboratory_worm_turns_fina.html The Oregonian]
[http://www.oregonlive.com/news/index.ssf/2009/10/the_laboratory_worm_turns_fina.html The Oregonian]
Line 90: Line 90:


[http://www.healthfinder.gov/news/newsstory.aspx?docid=632209 healthfinder.gov]
[http://www.healthfinder.gov/news/newsstory.aspx?docid=632209 healthfinder.gov]
[http://blog.taragana.com/n/why-sex-with-partner-is-always-a-good-idea-203046/ Asian News International]


[http://news.cnet.com/8301-27083_3-10380276-247.html CNET News]
[http://news.cnet.com/8301-27083_3-10380276-247.html CNET News]
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[[Image:Em.jpg|left|thumb|Research Partner]]
[[Image:Wwem.jpg|left|thumb|Research Partner]]




[[Image:wormmag.jpg|left|thumb|Research Assistant #1........ Cute Baby]]
[[Image:Mags.jpg|left|thumb|Research Assistant #1........ Cute Kid]]


[[Image:Beast.jpg|left|thumb|Research Assistant #2........ Fierce Beast]]
[[Image:Beastie.jpg|left|thumb|Research Assistant #2........ Fierce Beast]]


==Fun Stuff==
==Fun Stuff==
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'''Movies'''
'''Movies'''


*[http://www.starwarsuncut.com/ Star Wars Uncut] The rumors that I own a jedi robe are in fact true.
*[http://www.starwarsuncut.com/ Star Wars Uncut] I own a jedi robe.


'''Food'''
'''Food'''
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I like cheeseburgers, burritos, and subs more than anyone really should. Here are a few of my favorites:
I like cheeseburgers, burritos, and subs more than anyone really should. Here are a few of my favorites:
*[http://www.eugenecatering.com/ Cornucopia]- Best burgers in Eugene, OR!
*[http://www.eugenecatering.com/ Cornucopia]- Best burgers in Eugene, OR!
*[http://www.opietaylors.com/welcome.html Opie Taylor's]- Best burgers in Bloomington, IN! I attempted the Double Tank Burger Challenge and failed miserably. If you are up for a challenge, go for it! I hope you have better luck than me!
*[http://www.opietaylors.com/welcome.html Opie Taylor's]- Great burgers in Bloomington, IN! I attempted the Double Tank Burger Challenge and failed miserably. If you are up for a challenge, go for it! I hope you have better luck than me!
* Laughing Planet Cafe - Great burritos in [http://www.laughingplanetcafe.com/ Eugene] and [http://thelaughingplanetcafe.com/ Bloomington]!
* Laughing Planet Cafe - Great burritos in [http://www.laughingplanetcafe.com/ Eugene] and [http://thelaughingplanetcafe.com/ Bloomington]!
* [http://www.dagwoodsandwiches.com/ Dagwood's]- Awesome subs in B-Town! I highly recommend the Dagwood Supreme.
* [http://www.dagwoodsandwiches.com/ Dagwood's]- Awesome subs in B-Town! I highly recommend the Dagwood Supreme.

Latest revision as of 11:48, 18 July 2011

Contact Info

this is me
  • Levi T. Morran
  • lmorran@indiana.edu
Indiana University
Jordan Hall room 117
1001 E. 3rd St.
Bloomington, IN, USA


I am currently an NIH NRSA postdoc in the Lively lab at Indiana University.

Please email me if you would like a full version of my CV.

Education

  • 2009, PhD, University of Oregon
  • 2004, BS, Indiana University

Research interests

I am broadly interested in factors that either facilitate or constrain adaptive evolution. Currently I am exploring the roles that mating systems and coevolutionary dynamics play in adaptive evolution.

I utilize experimental evolution to directly test hypotheses and determine the manner in which evolution proceeds by characterizing both the phenotypic and genotypic changes that occur in evolving populations.

  • MATING SYSTEM EVOLUTION

Mating systems dictate the manner in which genes are transmitted from parent to offspring, and therefore determine the level of genetic variation within and between lineages of a population. Mating systems are a key component of reproduction, and reproduction is a basic requirement in biology. Despite this ubiquitous importance, many different mating systems exist in nature. I am interested in the selective pressures that favor specific mating systems, the genetic consequences of different mating systems, and their overall role in shaping the evolutionary trajectory of a population and/or lineage over time.

I primarily work with the nematode Caenorhabditis elegans to study mating systems because this species utilizes two different mating strategies, outcrossing and self-fertilization.

  • COEVOLUTIONARY DYNAMICS

Coevolution accounts for a significant proportion of the evolutionary change that occurs in nature. This is quite reasonable because most, if not all, species live as members of communities composed of many species. As a result of interactions between members in a community, many species utilize not only their own genome, but also the genome of other species to facilitate survival and reproduction in context of mutualistic interactions. Conversely, antagonistic interactions between species are capable of driving rapid evolutionary change between interacting species. Thus intergenomic interactions, resulting from both mutualistic and antagonistic coevolution, play a major role in shaping the evolutionary trajectory of many species. I am interested in learning how coevolutionary interactions affect each interacting species, and also understanding the role that mating systems play in determining the outcome of coevolutionary interactions.

I am working with C. elegans and the bacterial pathogen, Serratia marcescens, to study antagonistic coevolution. I am also working with the nematode Steinernema carpocapsae and its bacterial symbiont, Xenorhabdus nematophila, to study mutualistic coevolution.

Collaborators

Publications

  1. Morran, L.T., O.G. Schmidt, I.A. Gelarden, R.C. Parrish II, C.M. Lively. 2011. Running with the Red Queen: Host-parasite coevolution selects for bi-parental sex. Science. Jul 8; 333 (6039): 216-8.
  2. Morran, L.T., A. Ohdera, and P.C. Phillips. 2010. Purging deleterious mutations under self-fertilization: Paradoxical recovery in fitness with increasing mutation rate in Caenorhabditis elegans. PLoS ONE. 5(12): e14473. doi: 10.1371/journal.pone.0014473
  3. Anderson J.L., Morran L.T., Phillips P.C. 2010. Outcrossing and the maintenance of males within C. elegans populations. J Hered. Mar-Apr; 101 Suppl 1: S62-74.
  4. Morran L.T., Parmenter M.D., Phillips P.C. 2009. Mutation load and rapid adaptation favour outcrossing over self-fertilization. Nature. Nov 19; 462 (7271): 350-2.
  5. Morran L.T., Cappy B.J., Anderson J.L., Phillips P.C. 2009. Sexual partners for the stressed: facultative outcrossing in the self-fertilizing nematode Caenorhabditis elegans. Evolution. Jun; 63 (6): 1473-82.
  6. Bashey, F., L.T. Morran, and C.M. Lively. 2007. Coinfection, kin selection, and the rate of host exploitation by a parasitic nematode. Evolutionary Ecology Research 9: 947-958.

Research in News and Media Coverage

Running with the Red Queen:

Science Perspectives, Brockhurst, MA. 2011 Evolution: Sex, death, and the Red Queen.

BBC News

NPR

The Washington Post

Discover

LiveScience

Gawker

National Geographic News Watch

Purging deleterious mutations under self-fertilization:

Discover

Mutation load and rapid adaptation favour outcrossing over self-fertilization:

Faculty of 1000 review

News and Views, Agrawal, AF. 2009 Evolutionary biology: Why reproduction often takes two.

The Oregonian

Not Exactly Rocket Science

Discover

healthfinder.gov

CNET News

The following two links include sexual content that may not be suitable for all individuals:

Fark

Esarcasm

Science and Faith

I am an evolutionary biologist and a follower of Jesus. I chose evolutionary biology (and specifically experimental evolution) as a field of study to get a firsthand look at the process of evolution as part of a personal search for truth. After almost 10 years of research, I am continually fascinated by, and an ardent proponent of, evolution and its comprehensive ability to explain the diversity of life on Earth. My quest for truth through the study of evolution has only served to strengthen my faith and allowed me to experience intellectual and spiritual freedom by embracing both faith and science as integral components in my life.

Given my faith and my love of science, it should be no surprise that I have a keen interest in the creation/evolution debate currently ongoing in the United States. I believe that Intelligent Design and certain forms of Creationism threaten to undermine the scientific integrity of science classrooms across the country, while also marginalizing and sabotaging religious faith. I am particularly interested in making science and the scientific method accessible, comprehensible, and nonthreatening to faith-based groups in an effort to preserve scientific integrity and reconcile the fact of evolution with the choice to have faith in the supernatural.

I am profoundly interested in the relationship between science and faith. It is one of my favorite discussion points, so please feel free to email me with your thoughts or comments. I truly enjoy civil discussion and hearing different points of view.

Ken Miller and Francis Collins are excellent scientists and scholars that present compelling cases regarding the compatibility of science and faith. I highly recommend their work to anyone exploring this topic.

Organizations I Support

  • Team Zachary raises funds for Lymphoma research through the University of Nebraska Medical Center in memory of my best friend Zach May.
  • Smoky Mountain Great Dane Rescue, run by my brother and his wife, fosters, adopts, and advocates for Great Danes in the Southeastern US.
  • National Center for Science Education is an organization that advocates for the inclusion of evolution and exclusion of nonscientific "origins" theories in public school science curricula.

Lifetime Collaborators

Research Partner


Research Assistant #1........ Cute Kid
Research Assistant #2........ Fierce Beast

Fun Stuff

Sports

Music

  • WTTS Fm 92.3 From Dylan to Marley to Dave, they play great music.
  • Carbon Leaf Great band everyone should check out!
  • Mat Kearney Excellent musician and great performer!
  • I've been known to listen to some George Strait every now and then too.

Movies

Food

I like cheeseburgers, burritos, and subs more than anyone really should. Here are a few of my favorites:

  • Cornucopia- Best burgers in Eugene, OR!
  • Opie Taylor's- Great burgers in Bloomington, IN! I attempted the Double Tank Burger Challenge and failed miserably. If you are up for a challenge, go for it! I hope you have better luck than me!
  • Laughing Planet Cafe - Great burritos in Eugene and Bloomington!
  • Dagwood's- Awesome subs in B-Town! I highly recommend the Dagwood Supreme.
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