Lerou:Research

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Embryonic Stem Cell Colony Research Goals Our research goals are to advance the fundamental understanding of pluripotent stem cell biology in order to unlock their therapeutic and research potential. To achieve this goal we will plan to apply novel cell imaging techniques and genomic approaches to explore differentiation dynamics in human pluripotent stem cells. These techniques are coupled with single cell analysis and computational biology approaches to improve our understanding of complex characteristics associated with human pluripotency. Research Interests Human pluripotent stem cells: embryonic stem (ES) cells and induced pluripotency stem (iPS) cells Genomic stability regulation in human pluripotent stem cells Cell cycle regulation of human pluripotent stem cells p53 dynamics of human pluripotent stem cells Multi-scale quantitative imaging and single-cell feature analysis Transcription dynamics in space and time during stem cell differentiation – in collaboration with Jeremy Purvis @UNC (LINK) and Hu Li @ Mayo Clinic Embryonic Stem Cells, DNA labeled with GFP