Lee:Literature Transporters

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• Recent OATP papers: PubMed, Cite-U-Like

Transporters general review

1. Alrefai WA and Gill RK. Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm Res. 2007 Oct;24(10):1803-23. DOI:10.1007/s11095-007-9289-1 |
2. Dawson PA, Lan T, and Rao A. Bile acid transporters. J Lipid Res. 2009 Dec;50(12):2340-57. DOI:10.1194/jlr.R900012-JLR200 |
3. DuBuske LM. The role of P-glycoprotein and organic anion-transporting polypeptides in drug interactions. Drug Saf. 2005;28(9):789-801. DOI:10.2165/00002018-200528090-00004 |

OATP family general review

1. Hagenbuch B and Meier PJ. Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch. 2004 Feb;447(5):653-65. DOI:10.1007/s00424-003-1168-y |
2. Niemi M. Role of OATP transporters in the disposition of drugs. Pharmacogenomics. 2007 Jul;8(7):787-802. DOI:10.2217/14622416.8.7.787 |

OATP1B3

1. Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, Nunoki K, Sato E, Kakyo M, Nishio T, Sugita J, Asano N, Tanemoto M, Seki M, Date F, Ono K, Kondo Y, Shiiba K, Suzuki M, Ohtani H, Shimosegawa T, Iinuma K, Nagura H, Ito S, and Matsuno S. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. DOI:10.1053/gast.2001.24804 |
2. Gui C and Hagenbuch B. Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport. Biochemistry. 2008 Sep 2;47(35):9090-7. DOI:10.1021/bi8008455 |
3. Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, and Tsuji A. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DOI:10.1006/bbrc.2000.2922 |
4. Vavricka SR, Jung D, Fried M, Grützner U, Meier PJ, and Kullak-Ublick GA. The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma. J Hepatol. 2004 Feb;40(2):212-8. DOI:10.1016/j.jhep.2003.10.008 |
5. Muto M, Onogawa T, Suzuki T, Ishida T, Rikiyama T, Katayose Y, Ohuchi N, Sasano H, Abe T, and Unno M. Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma. Cancer Sci. 2007 Oct;98(10):1570-6. DOI:10.1111/j.1349-7006.2007.00570.x |
6. Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N, Venzon D, Maeda K, Nagao K, Sparreboom A, Mitsuya H, Dahut WL, and Figg WD. Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer. Clin Cancer Res. 2008 Jun 1;14(11):3312-8. DOI:10.1158/1078-0432.CCR-07-4118 |
7. Ohtsuka H, Abe T, Onogawa T, Kondo N, Sato T, Oshio H, Mizutamari H, Mikkaichi T, Oikawa M, Rikiyama T, Katayose Y, and Unno M. Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene. J Gastroenterol. 2006 Apr;41(4):369-77. DOI:10.1007/s00535-006-1784-3 |
8. Sharifi N, Hamada A, Sissung T, Danesi R, Venzon D, Baum C, Gulley JL, Price DK, Dahut WL, and Figg WD. A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer. BJU Int. 2008 Aug 5;102(5):617-21. DOI:10.1111/j.1464-410X.2008.07629.x |
9. Gui C, Miao Y, Thompson L, Wahlgren B, Mock M, Stieger B, and Hagenbuch B. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65. DOI:10.1016/j.ejphar.2008.01.042 |
10. Yamaguchi H, Kobayashi M, Okada M, Takeuchi T, Unno M, Abe T, Goto J, Hishinuma T, and Mano N. Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes. Cancer Lett. 2008 Feb 18;260(1-2):163-9. DOI:10.1016/j.canlet.2007.10.040 |
11. Mahagita C, Grassl SM, Piyachaturawat P, and Ballatori N. Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport. Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G271-8. DOI:10.1152/ajpgi.00075.2007 |
12. Komatsu M, Furukawa T, Ikeda R, Takumi S, Nong Q, Aoyama K, Akiyama S, Keppler D, and Takeuchi T. Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3. Toxicol Sci. 2007 Jun;97(2):407-16. DOI:10.1093/toxsci/kfm054 |
13. Monks NR, Liu S, Xu Y, Yu H, Bendelow AS, and Moscow JA. Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells. Mol Cancer Ther. 2007 Feb;6(2):587-98. DOI:10.1158/1535-7163.MCT-06-0500 |
14. Smith NF, Marsh S, Scott-Horton TJ, Hamada A, Mielke S, Mross K, Figg WD, Verweij J, McLeod HL, and Sparreboom A. Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics. Clin Pharmacol Ther. 2007 Jan;81(1):76-82. DOI:10.1038/sj.clpt.6100011 |
15. Briz O, Romero MR, Martinez-Becerra P, Macias RI, Perez MJ, Jimenez F, San Martin FG, and Marin JJ. OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes?. J Biol Chem. 2006 Oct 13;281(41):30326-35. DOI:10.1074/jbc.M602048200 |

P-glycoprotein (MDR1)

1. Aszalos A. Drug-drug interactions affected by the transporter protein, P-glycoprotein (ABCB1, MDR1) I. Preclinical aspects. Drug Discov Today. 2007 Oct;12(19-20):833-7. DOI:10.1016/j.drudis.2007.07.022 |
2. Aszalos A. Drug-drug interactions affected by the transporter protein, P-glycoprotein (ABCB1, MDR1) II. Clinical aspects. Drug Discov Today. 2007 Oct;12(19-20):838-43. DOI:10.1016/j.drudis.2007.07.021 |
3. Marchetti S, Mazzanti R, Beijnen JH, and Schellens JH. Concise review: Clinical relevance of drug drug and herb drug interactions mediated by the ABC transporter ABCB1 (MDR1, P-glycoprotein). Oncologist. 2007 Aug;12(8):927-41. DOI:10.1634/theoncologist.12-8-927 |

bile acid signaling

1. Donnellan F, Keating N, Geoghegan P, Murray FE, Harvey BJ, and Keely SJ. JNK mitogen-activated protein kinase limits calcium-dependent chloride secretion across colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2010 Jan;298(1):G37-44. DOI:10.1152/ajpgi.00202.2009 |
2. Cáceres M, Tobar N, Guerrero J, Smith PC, and Martínez J. c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway. J Cell Biochem. 2008 Feb 15;103(3):986-93. DOI:10.1002/jcb.21469 |
3. Sommerfeld A, Reinehr R, and Häussinger D. Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. J Biol Chem. 2009 Aug 14;284(33):22173-22183. DOI:10.1074/jbc.M109.005355 |
4. Takeuchi K, Shin-ya T, Nishio K, and Ito F. Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase. FEBS J. 2009 Mar;276(5):1255-65. DOI:10.1111/j.1742-4658.2008.06861.x |
5. Ding G, Zhang A, Huang S, Pan X, Zhen G, Chen R, and Yang T. ANG II induces c-Jun NH2-terminal kinase activation and proliferation of human mesangial cells via redox-sensitive transactivation of the EGFR. Am J Physiol Renal Physiol. 2007 Dec;293(6):F1889-97. DOI:10.1152/ajprenal.00112.2007 |