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[[Lee | <font face="trebuchet ms" style="color:#ffffff"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
== Principal investigator ==
[[Lee:Research | <font face="trebuchet ms" style="color:#ffffff"> '''Research''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
* Wooin Lee, Ph.D
[[Lee:Lab Members | <font face="trebuchet ms" style="color:#ffffff"> '''Lab Members''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Lee:Publications | <font face="trebuchet ms" style="color:#ffffff"> '''Publications''' </font>]]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Lee:Literature Transporters | <font face="trebuchet ms" style="color:#ffffff"> '''Transporters''' </font>]]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Lee:Literature Proteasomes | <font face="trebuchet ms" style="color:#ffffff"> '''Proteasomes''' </font>]]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Lee:Literature PK/PD/PGx | <font face="trebuchet ms" style="color:#ffffff"> '''PK/PD/PGx''' </font>]]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Lee:JC | <font face="trebuchet ms" style="color:#ffffff"> '''JC''' </font>]]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Lee:Links | <font face="trebuchet ms" style="color:#ffffff"> '''Links''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Lee:Back Door | <font face="trebuchet ms" style="color:#ffffff"> '''Internal''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Lee:Contact | <font face="trebuchet ms" style="color:#ffffff"> '''Contact''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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== Principal investigator ==
== Graduate students ==
Wooin Lee, Ph.D.
 
* 이성수 Seongsu Lee (Combined MS/PhD program, 2021 Fall - )
* 김지영 Jiyoung Kim (PhD program, 2021 Fall - )
* 박신영 Shinyoung Park (Combined MS/PhD program, 2023 Spring - )
* 곽희천 (PhD program)
* 진성민 (Combined MS/PhD program, 2024 Spring - )
* 도경민 (Combined MS/PhD program, 2024 Spring - )
* 양승아 (Combined MS/PhD program, 2024 Spring - )
* 변선영 (MS program, 2024 Spring - )


== Post-doctoral associate ==
== Alumni ==
Eun Ryoung Jang, Ph.D.
* Kyunghwa Kim (2009-2011, a research assistant at UK, currently at CJ Healthcare)
* Eun Ryoung Jang, Ph.D. (a postdoc at UK, 2009-2011)
* Dong-hern Kim, Ph.D. (a postdoc at UK, 2011)
* Daniel Machado (UK, an undergrad research student and a research assistant, 2009-2012)
* Songhee Han, Ph.D. (an exchange student at UK, 2011-2012; a postdoc at SNU, 2015-2016; currently at 안전성평가연구원)
* Kyungbo Kim (2012-2013, currently a postdoc at UK)
* Youngran Lim (Konkuk University, an exchange student at UK, 2012-2013)
* 백우현 (2020-2021)
* Jingyan Chen (2021)
* 박세원 Sewon Park (2022-3)
{| border="1"
|+
|width='140'|'''Name (degree)'''
|width='60'|'''Year'''
|width='500'|'''Thesis Title (current position)'''
|-
|Nilay Thakkar (PhD) || 2010-15 || Molecular & Functional Investigations of Cancer-type and Liver-type Variants of Organic Anion Transporting Polypeptide 1B3 (currently at GSK, USA)
|-
|Lin Ao (PhD) || 2012-16 || Investigating Mechanisms Determining Cancer Cell Sensitivity to Carfilzomib and Novel Strategies to Overcome Carfilzomib Resistance (currently at Dana-Farber Cancer Institute, USA)
|-
|Se Eun Chun (MS)|| 2015-17  || The N-terminal Region of OATP1B3 Plays an Essential Role in Regulating its Plasma Membrane Trafficking (currently at LG Chem)
|-
|Yunseok Oh (MS) || 2016-18 || Inhibition of Organic Anion Transporting Polypeptides (OATP1B1 & 1B3) by Betulinic Acid: Effects of Pre-incubation and Albumin in the Media (currently at Dong-A Pharmaceutical. Co.)
|-
|Gongmi Ryoo (MS)|| 2016-18 || Mechanisms Regulating the Expression of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) in Hepatic Cancer Cells: Hypoxia and Epigenetic Alteration
|-
|Ji Eun Park (PhD)|| 2015-19 || Pharmacokinetics and pharmacodynamics of novel nanoformulations for the proteasome inhibitor drug carfilzomib: Expanding its therapeutic utility against solid cancers (currently at Riken, Japan)
|-
|Yearin Jun (MS)|| 2017-19 || Pharmacokinetic profiles of quinic acid-conjugated nanoparticles for the proteasome inhibitor drug carfilzomib: Improved ''in vivo'' stability and tumoral drug accumulation (currently at Dong-A Pharmaceutical. Co.)
|-
|Ji Yoon Choi (MS)|| 2018 - 2020 || Impact of histone deacetylase inhibitor romidepsin on the expression and function of organic anion transporter polypeptide 2B1 (OATP2B1) in liver cancer cell lines (currently at 안국약품)
|-
|Naeun Yoon (MS)|| 2018 - 2020 || Regulation of organic anion-transporting polypeptide 1B3 (OATP1B3) variants in human hepatic cancer cells: Impact of hypoxia-mimicking agents and DNA methyltransferase 1 inhibitors (currently at 한국 MSD)
|-
|Jisu Yoo (MS)|| 2018 - 2020 || Evaluation of Epoxyketone-based Immunoproteasome-selective Inhibitors with Enhanced Brain Distribution and Stability In Vitro & In Vivo
|-
|Hyeryung Jang (MS)|| 2019 - 2021 || Pharmacokinetic evaluation of the novel macrocyclic immunoproteasome-selective inhibitor DB55 in mice: Focus on brain penetration and metabolic stability
|-
|Jeong-min Ha (MS)|| 2019 - 2021 || Impact of the naturally occurring c.421C>A variation of the ATP binding cassette superfamily G member 2 (ABCG2) gene on its protein degradation and dimerization
|-
|}<br>


== Research Associate ==
== Research rotation/internship students (past) ==
Kyunghwa Kim, M.S.
* Joshua Spicer (Asbury University, 2009 Summer)
* Emily Boone (UK, Pharmacy, 2010 Summer)
* Trang Nguyen (UK, Pharmacy)
* Michael Agius (Grand Valley State University, 2011 Summer undergrad research program)
* Yijia "Selina" Yi (Centre College, 2012 Summer undergrad research program)
* Christian Rhudy (Transylvania University, 2013 Summer undergrad research program)
* Jiamin Liu (China Pharmaceutical University, 2018 research internship program)
* Joanne Yu-Xuan Lin (Purdue Univ, 2018 Summer global undergrad internship program)
* Jungwon Jason Park (Purdue Univ, 2019 Summer global undergrad internship program)
* Seungbin Kwon (Purdue Univ, 2020 Summer)
* 김경민 (성균관대학교, 2021 Summer)
* 박세원 (중앙대학교, 2021 Summer)
* 박신영 (중앙대학교, 2021 Winter)
* 김지은 (DGIST, 2022 Summer)
* 박신영 (아주대학교, 2022 Summer)
* 김예원 (동덕여대, 2023 Winter)
* 최종우 (중앙대학교, 2023 Winter)
* 변선영 (덕성여대, 2023 May)
* 양승아 (경희대학교, 2023 July)
* 도경민 (건국대학교, 2023 July)
* 유다영 (우석대학교, 2023 July)
* 진성민 (경희대학교, 2023 July)
* 함세희 (순천향대학교, 2024 Winter)
* 양희서 (중앙대학교, 2024 Winter)
* 김시원 (건국대학교, 2024 Winter)


== Undergraduate student ==
심화실습@SNU (15-week research rotation)
Joshua Spicer (Asbury College, 09Summer)
{| border="1"
|+
|width='130'|'''Name'''
|width='60'|'''Year'''
|-
|신진아, 오윤석  || 2015 
|-
|이연희, 김민경 || 2016
|-
|유지수, 윤나은 || 2017
|-
|장혜령, 하정민 || 2018 
|-
|유선아 || 2019 
|-
|고상균 || 2022 
|-
|}<br>

Latest revision as of 04:39, 12 February 2024

Home                  Research                  Lab Members                  Publications                  JC                      Links                  Internal                  Contact                 

Principal investigator

  • Wooin Lee, Ph.D

Graduate students

  • 이성수 Seongsu Lee (Combined MS/PhD program, 2021 Fall - )
  • 김지영 Jiyoung Kim (PhD program, 2021 Fall - )
  • 박신영 Shinyoung Park (Combined MS/PhD program, 2023 Spring - )
  • 곽희천 (PhD program)
  • 진성민 (Combined MS/PhD program, 2024 Spring - )
  • 도경민 (Combined MS/PhD program, 2024 Spring - )
  • 양승아 (Combined MS/PhD program, 2024 Spring - )
  • 변선영 (MS program, 2024 Spring - )

Alumni

  • Kyunghwa Kim (2009-2011, a research assistant at UK, currently at CJ Healthcare)
  • Eun Ryoung Jang, Ph.D. (a postdoc at UK, 2009-2011)
  • Dong-hern Kim, Ph.D. (a postdoc at UK, 2011)
  • Daniel Machado (UK, an undergrad research student and a research assistant, 2009-2012)
  • Songhee Han, Ph.D. (an exchange student at UK, 2011-2012; a postdoc at SNU, 2015-2016; currently at 안전성평가연구원)
  • Kyungbo Kim (2012-2013, currently a postdoc at UK)
  • Youngran Lim (Konkuk University, an exchange student at UK, 2012-2013)
  • 백우현 (2020-2021)
  • Jingyan Chen (2021)
  • 박세원 Sewon Park (2022-3)
Name (degree) Year Thesis Title (current position)
Nilay Thakkar (PhD) 2010-15 Molecular & Functional Investigations of Cancer-type and Liver-type Variants of Organic Anion Transporting Polypeptide 1B3 (currently at GSK, USA)
Lin Ao (PhD) 2012-16 Investigating Mechanisms Determining Cancer Cell Sensitivity to Carfilzomib and Novel Strategies to Overcome Carfilzomib Resistance (currently at Dana-Farber Cancer Institute, USA)
Se Eun Chun (MS) 2015-17 The N-terminal Region of OATP1B3 Plays an Essential Role in Regulating its Plasma Membrane Trafficking (currently at LG Chem)
Yunseok Oh (MS) 2016-18 Inhibition of Organic Anion Transporting Polypeptides (OATP1B1 & 1B3) by Betulinic Acid: Effects of Pre-incubation and Albumin in the Media (currently at Dong-A Pharmaceutical. Co.)
Gongmi Ryoo (MS) 2016-18 Mechanisms Regulating the Expression of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) in Hepatic Cancer Cells: Hypoxia and Epigenetic Alteration
Ji Eun Park (PhD) 2015-19 Pharmacokinetics and pharmacodynamics of novel nanoformulations for the proteasome inhibitor drug carfilzomib: Expanding its therapeutic utility against solid cancers (currently at Riken, Japan)
Yearin Jun (MS) 2017-19 Pharmacokinetic profiles of quinic acid-conjugated nanoparticles for the proteasome inhibitor drug carfilzomib: Improved in vivo stability and tumoral drug accumulation (currently at Dong-A Pharmaceutical. Co.)
Ji Yoon Choi (MS) 2018 - 2020 Impact of histone deacetylase inhibitor romidepsin on the expression and function of organic anion transporter polypeptide 2B1 (OATP2B1) in liver cancer cell lines (currently at 안국약품)
Naeun Yoon (MS) 2018 - 2020 Regulation of organic anion-transporting polypeptide 1B3 (OATP1B3) variants in human hepatic cancer cells: Impact of hypoxia-mimicking agents and DNA methyltransferase 1 inhibitors (currently at 한국 MSD)
Jisu Yoo (MS) 2018 - 2020 Evaluation of Epoxyketone-based Immunoproteasome-selective Inhibitors with Enhanced Brain Distribution and Stability In Vitro & In Vivo
Hyeryung Jang (MS) 2019 - 2021 Pharmacokinetic evaluation of the novel macrocyclic immunoproteasome-selective inhibitor DB55 in mice: Focus on brain penetration and metabolic stability
Jeong-min Ha (MS) 2019 - 2021 Impact of the naturally occurring c.421C>A variation of the ATP binding cassette superfamily G member 2 (ABCG2) gene on its protein degradation and dimerization

Research rotation/internship students (past)

  • Joshua Spicer (Asbury University, 2009 Summer)
  • Emily Boone (UK, Pharmacy, 2010 Summer)
  • Trang Nguyen (UK, Pharmacy)
  • Michael Agius (Grand Valley State University, 2011 Summer undergrad research program)
  • Yijia "Selina" Yi (Centre College, 2012 Summer undergrad research program)
  • Christian Rhudy (Transylvania University, 2013 Summer undergrad research program)
  • Jiamin Liu (China Pharmaceutical University, 2018 research internship program)
  • Joanne Yu-Xuan Lin (Purdue Univ, 2018 Summer global undergrad internship program)
  • Jungwon Jason Park (Purdue Univ, 2019 Summer global undergrad internship program)
  • Seungbin Kwon (Purdue Univ, 2020 Summer)
  • 김경민 (성균관대학교, 2021 Summer)
  • 박세원 (중앙대학교, 2021 Summer)
  • 박신영 (중앙대학교, 2021 Winter)
  • 김지은 (DGIST, 2022 Summer)
  • 박신영 (아주대학교, 2022 Summer)
  • 김예원 (동덕여대, 2023 Winter)
  • 최종우 (중앙대학교, 2023 Winter)
  • 변선영 (덕성여대, 2023 May)
  • 양승아 (경희대학교, 2023 July)
  • 도경민 (건국대학교, 2023 July)
  • 유다영 (우석대학교, 2023 July)
  • 진성민 (경희대학교, 2023 July)
  • 함세희 (순천향대학교, 2024 Winter)
  • 양희서 (중앙대학교, 2024 Winter)
  • 김시원 (건국대학교, 2024 Winter)

심화실습@SNU (15-week research rotation)

Name Year
신진아, 오윤석 2015
이연희, 김민경 2016
유지수, 윤나은 2017
장혜령, 하정민 2018
유선아 2019
고상균 2022