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Schedule (biweekly, 10am - ) date Presenter 4/6 (Sat) zoom meeting 4/13 (Sat) zoom meeting 4/27 (Sat) zoom meeting 5/4 (Sat) zoom meeting 5/11 (Sat) zoom meeting Past papers 2024 Chen R, Yang J, Mao Y, Zhao X, Cheng R, Deng C, and Zhong Z. Antibody-Mediated Nanodrug of Proteasome Inhibitor Carfilzomib Boosts the Treatment of Multiple Myeloma. Biomacromolecules. 2023 Nov 13;24(11):5371-5380. DOI:10.1021/acs.biomac.3c00830 | Henriksen U, Gether U, and Litman T. Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2. J Cell Sci. 2005 Apr 1;118(Pt 7):1417-26. DOI:10.1242/jcs.01729 | Sahoo RK, Gothwal A, Rani S, Nakhate KT, Ajazuddin, and Gupta U. PEGylated Dendrimer Mediated Delivery of Bortezomib: Drug Conjugation versus Encapsulation. Int J Pharm. 2020 Jun 30;584:119389. DOI:10.1016/j.ijpharm.2020.119389 | Kim H, Yuk SA, Dieterly AM, Kwon S, Park J, Meng F, Gadalla HH, Cadena MJ, Lyle LT, and Yeo Y. Nanosac, a Noncationic and Soft Polyphenol Nanocapsule, Enables Systemic Delivery of siRNA to Solid Tumors. ACS Nano. 2021 Mar 23;15(3):4576-4593. DOI:10.1021/acsnano.0c08694 | Wook Kang D, Hee Kim J, and Cho HY. Approaches for estimating the clinical starting dose of new dosage forms: An example of a long-acting injectable formulation of finasteride. Int J Pharm. 2023 Jan 25;631:122510. DOI:10.1016/j.ijpharm.2022.122510 | Bartos Z and Homolya L. Identification of Specific Trafficking Defects of Naturally Occurring Variants of the Human ABCG2 Transporter. Front Cell Dev Biol. 2021;9:615729. DOI:10.3389/fcell.2021.615729 | 2023 Zhang Y, Hays A, Noblett A, Thapa M, Hua DH, and Hagenbuch B. Transport by OATP1B1 and OATP1B3 enhances the cytotoxicity of epigallocatechin 3-O-gallate and several quercetin derivatives. J Nat Prod. 2013 Mar 22;76(3):368-73. DOI:10.1021/np3007292 | Kim J, Park KE, Jeong YS, Kim Y, Park H, Nam JH, Jung K, Son WS, Jung HS, Lee JH, Jeong SH, Kim NA, Ha JD, Cho SY, Choi YL, Chung SJ, Choi JY, Hong S, and Shin YK. Therapeutic Efficacy of ABN401, a Highly Potent and Selective MET Inhibitor, Based on Diagnostic Biomarker Test in MET-Addicted Cancer. Cancers (Basel). 2020 Jun 15;12(6). DOI:10.3390/cancers12061575 | Modernelli A, Naponelli V, Giovanna Troglio M, Bonacini M, Ramazzina I, Bettuzzi S, and Rizzi F. EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism. Sci Rep. 2015 Oct 16;5:15270. DOI:10.1038/srep15270 | Sarankó H, Tordai H, Telbisz Á, Özvegy-Laczka C, Erdős G, Sarkadi B, and Hegedűs T. Effects of the gout-causing Q141K polymorphism and a CFTR ΔF508 mimicking mutation on the processing and stability of the ABCG2 protein. Biochem Biophys Res Commun. 2013 Jul 19;437(1):140-5. DOI:10.1016/j.bbrc.2013.06.054 | 2022 Sissung TM, Ley AM, Strope JD, McCrea EM, Beedie S, Peer CJ, Shukla S, van Velkinburgh J, Reece K, Troutman S, Campbell T, Fernandez E, Huang P, Smith J, Thakkar N, Venzon DJ, Brenner S, Lee W, Merino M, Luo J, Jager W, Price DK, Chau CH, and Figg WD. Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx. Mol Cancer Res. 2017 Aug;15(8):1096-1105. DOI:10.1158/1541-7786.MCR-16-0477 | Koyama S, Toshimoto K, Lee W, Aoki Y, and Sugiyama Y. Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy. Drug Metab Dispos. 2021 Apr;49(4):298-304. DOI:10.1124/dmd.120.000023 | Wang Z, Yang J, Kirk C, Fang Y, Alsina M, Badros A, Papadopoulos K, Wong A, Woo T, Bomba D, Li J, and Infante JR. Clinical pharmacokinetics, metabolism, and drug-drug interaction of carfilzomib. Drug Metab Dispos. 2013 Jan;41(1):230-7. DOI:10.1124/dmd.112.047662 | Hove VN, Anderson K, Hayden ER, Pasquariello KZ, Gibson AA, Shen S, Qu J, Jin Y, Miecznikowski JC, Hu S, and Sprowl JA. Influence of Tyrosine Kinase Inhibition on Organic Anion Transporting Polypeptide 1B3-Mediated Uptake. Mol Pharmacol. 2022 Jun;101(6):381-389. DOI:10.1124/molpharm.121.000287 | Byrgazov K, Kraus M, Besse A, Slipicevic A, Lehmann F, Driessen C, and Besse L. Up-regulation of multidrug resistance protein MDR1/ABCB1 in carfilzomib-resistant multiple myeloma differentially affects efficacy of anti-myeloma drugs. Leuk Res. 2021 Feb;101:106499. DOI:10.1016/j.leukres.2020.106499 | Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Fève B, Vigouroux C, Andreelli F, and Jeru I. EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. Elife. 2021 Aug 3;10. DOI:10.7554/eLife.68445 | Smith NF, Acharya MR, Desai N, Figg WD, and Sparreboom A. Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer Biol Ther. 2005 Aug;4(8):815-8. DOI:10.4161/cbt.4.8.1867 | Zhang Y, Ruggiero M, and Hagenbuch B. OATP1B3 Expression and Function is Modulated by Coexpression with OCT1, OATP1B1, and NTCP. Drug Metab Dispos. 2020 Aug;48(8):622-630. DOI:10.1124/dmd.119.089847 | Wang Q, Spenkelink B, Boonpawa R, and Rietjens IMCM. Use of Physiologically Based Pharmacokinetic Modeling to Predict Human Gut Microbial Conversion of Daidzein to S-Equol. J Agric Food Chem. 2022 Jan 12;70(1):343-352. DOI:10.1021/acs.jafc.1c03950 | Williamson B, Harlfinger S, and McGinnity DF. Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance. Drug Metab Dispos. 2020 Nov;48(11):1137-1146. DOI:10.1124/dmd.120.000131 | Kiriyama A, Honbo A, and Iga K. Analysis of hepatic metabolism affecting pharmacokinetics of propranolol in humans. Int J Pharm. 2008 Feb 12;349(1-2):53-60. DOI:10.1016/j.ijpharm.2007.07.019 | Chen W, Qian J, Fu J, Wu T, Lv M, Jiang S, and Zhang J. Changes in the Gut Microbiota May Affect the Clinical Efficacy of Oral Anticoagulants. Front Pharmacol. 2022;13:860237. DOI:10.3389/fphar.2022.860237 | 2021 Bartos Z and Homolya L. Identification of Specific Trafficking Defects of Naturally Occurring Variants of the Human ABCG2 Transporter. Front Cell Dev Biol. 2021;9:615729. DOI:10.3389/fcell.2021.615729 | Wang Z, Yang J, Kirk C, Fang Y, Alsina M, Badros A, Papadopoulos K, Wong A, Woo T, Bomba D, Li J, and Infante JR. Clinical pharmacokinetics, metabolism, and drug-drug interaction of carfilzomib. Drug Metab Dispos. 2013 Jan;41(1):230-7. DOI:10.1124/dmd.112.047662 | Woodle ES, Tremblay S, Brailey P, Girnita A, Alloway RR, Aronow B, Dasgupta N, Ebstein F, Kloetzel PM, Lee MJ, Kim KB, Singh H, and Driscoll JJ. Proteasomal adaptations underlying carfilzomib-resistance in human bone marrow plasma cells. Am J Transplant. 2020 Feb;20(2):399-410. DOI:10.1111/ajt.15634 | Ji P, Wang L, Chen Y, Wang S, Wu Z, and Qi X. Hyaluronic acid hydrophilic surface rehabilitating curcumin nanocrystals for targeted breast cancer treatment with prolonged biodistribution. Biomater Sci. 2020 Jan 1;8(1):462-472. DOI:10.1039/c9bm01605h | Wagner LK, Gilling KE, Schormann E, Kloetzel PM, Heppner FL, Krüger E, and Prokop S. Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice. Acta Neuropathol Commun. 2017 Jun 24;5(1):52. DOI:10.1186/s40478-017-0453-5 | Yu J, Liu J, Li D, Xu L, Hong D, Chang S, Xu L, Li J, Liu T, and Zhou Y. Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors. Eur J Med Chem. 2019 Feb 15;164:423-439. DOI:10.1016/j.ejmech.2018.12.072 | Yang J, Wang Z, Fang Y, Jiang J, Zhao F, Wong H, Bennett MK, Molineaux CJ, and Kirk CJ. Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats. Drug Metab Dispos. 2011 Oct;39(10):1873-82. DOI:10.1124/dmd.111.039164 | Kraus M, Bader J, Geurink PP, Weyburne ES, Mirabella AC, Silzle T, Shabaneh TB, van der Linden WA, de Bruin G, Haile SR, van Rooden E, Appenzeller C, Li N, Kisselev AF, Overkleeft H, and Driessen C. The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells. Haematologica. 2015 Oct;100(10):1350-60. DOI:10.3324/haematol.2014.109421 | Meyer Zu Schwabedissen HE, Seibert I, Grube M, Alter CL, Siegmund W, and Hussner J. Genetic variants of SLCO1B7 are of relevance for the transport function of OATP1B3-1B7. Pharmacol Res. 2020 Nov;161:105155. DOI:10.1016/j.phrs.2020.105155 | Li D, Zhang X, Ma X, Xu L, Yu J, Gao L, Hu X, Zhang J, Dong X, Li J, Liu T, Zhou Y, and Hu Y. Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors. J Med Chem. 2018 Oct 25;61(20):9177-9204. DOI:10.1021/acs.jmedchem.8b00819 | Fang Y, Johnson H, Anderl JL, Muchamuel T, McMinn D, Morisseau C, Hammock BD, Kirk C, and Wang J. Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome. Drug Metab Dispos. 2021 Sep;49(9):810-821. DOI:10.1124/dmd.120.000307 | Farasyn T, Pahwa S, Xu C, and Yue W. Pre-incubation with OATP1B1 and OATP1B3 inhibitors potentiates inhibitory effects in physiologically relevant sandwich-cultured primary human hepatocytes. Eur J Pharm Sci. 2021 Oct 1;165:105951. DOI:10.1016/j.ejps.2021.105951 | Rosa M, Bonnaillie P, and Chanteux H. Prediction of drug-drug interactions with carbamazepine-10,11-epoxide using a new in vitro assay for epoxide hydrolase inhibition. Xenobiotica. 2016 Dec;46(12):1076-1084. DOI:10.3109/00498254.2016.1151088 | Farasyn T, Crowe A, Hatley O, Neuhoff S, Alam K, Kanyo J, Lam TT, Ding K, and Yue W. Preincubation With Everolimus and Sirolimus Reduces Organic Anion-Transporting Polypeptide (OATP)1B1- and 1B3-Mediated Transport Independently of mTOR Kinase Inhibition: Implication in Assessing OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions. J Pharm Sci. 2019 Oct;108(10):3443-3456. DOI:10.1016/j.xphs.2019.04.019 | Wu N and An G. Incorporating Pharmacological Target-Mediated Drug Disposition (TMDD) in a Whole-Body Physiologically Based Pharmacokinetic (PBPK) Model of Linagliptin in Rat and Scale-up to Human. AAPS J. 2020 Sep 29;22(6):125. DOI:10.1208/s12248-020-00481-w | Li N, Badrinarayanan A, Ishida K, Li X, Roberts J, Wang S, Hayashi M, and Gupta A. Albumin-Mediated Uptake Improves Human Clearance Prediction for Hepatic Uptake Transporter Substrates Aiding a Mechanistic In Vitro-In Vivo Extrapolation (IVIVE) Strategy in Discovery Research. AAPS J. 2020 Nov 16;23(1):1. DOI:10.1208/s12248-020-00528-y | Miyauchi S, Masuda M, Kim SJ, Tanaka Y, Lee KR, Iwakado S, Nemoto M, Sasaki S, Shimono K, Tanaka Y, and Sugiyama Y. The Phenomenon of Albumin-Mediated Hepatic Uptake of Organic Anion Transport Polypeptide Substrates: Prediction of the In Vivo Uptake Clearance from the In Vitro Uptake by Isolated Hepatocytes Using a Facilitated-Dissociation Model. Drug Metab Dispos. 2018 Mar;46(3):259-267. DOI:10.1124/dmd.117.077115 | Li N, Kulkarni P, Badrinarayanan A, Kefelegn A, Manoukian R, Li X, Prasad B, Karasu M, McCarty WJ, Knutson CG, and Gupta A. P-glycoprotein Substrate Assessment in Drug Discovery: Application of Modeling to Bridge Differential Protein Expression Across In Vitro Tools. J Pharm Sci. 2021 Jan;110(1):325-337. DOI:10.1016/j.xphs.2020.09.017 | 2020 Henriksen U, Gether U, and Litman T. Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2. J Cell Sci. 2005 Apr 1;118(Pt 7):1417-26. DOI:10.1242/jcs.01729 | Li D, Zhang X, Ma X, Xu L, Yu J, Gao L, Hu X, Zhang J, Dong X, Li J, Liu T, Zhou Y, and Hu Y. Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors. J Med Chem. 2018 Oct 25;61(20):9177-9204. DOI:10.1021/acs.jmedchem.8b00819 | Talamini L, Violatto MB, Cai Q, Monopoli MP, Kantner K, Krpetić Ž, Perez-Potti A, Cookman J, Garry D, P Silveira C, Boselli L, Pelaz B, Serchi T, Cambier S, Gutleb AC, Feliu N, Yan Y, Salmona M, Parak WJ, Dawson KA, and Bigini P. Influence of Size and Shape on the Anatomical Distribution of Endotoxin-Free Gold Nanoparticles. ACS Nano. 2017 Jun 27;11(6):5519-5529. DOI:10.1021/acsnano.7b00497 | Di K, Lloyd GK, Abraham V, MacLaren A, Burrows FJ, Desjardins A, Trikha M, and Bota DA. Marizomib activity as a single agent in malignant gliomas: ability to cross the blood-brain barrier. Neuro Oncol. 2016 Jun;18(6):840-8. DOI:10.1093/neuonc/nov299 | Woodward OM, Tukaye DN, Cui J, Greenwell P, Constantoulakis LM, Parker BS, Rao A, Köttgen M, Maloney PC, and Guggino WB. Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5223-8. DOI:10.1073/pnas.1214530110 | Sindhwani S, Syed AM, Ngai J, Kingston BR, Maiorino L, Rothschild J, MacMillan P, Zhang Y, Rajesh NU, Hoang T, Wu JLY, Wilhelm S, Zilman A, Gadde S, Sulaiman A, Ouyang B, Lin Z, Wang L, Egeblad M, and Chan WCW. The entry of nanoparticles into solid tumours. Nat Mater. 2020 May;19(5):566-575. DOI:10.1038/s41563-019-0566-2 | Hoque KM, Dixon EE, Lewis RM, Allan J, Gamble GD, Phipps-Green AJ, Halperin Kuhns VL, Horne AM, Stamp LK, Merriman TR, Dalbeth N, and Woodward OM. The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion. Nat Commun. 2020 Jun 2;11(1):2767. DOI:10.1038/s41467-020-16525-w | Liu S, Ono RJ, Yang C, Gao S, Ming Tan JY, Hedrick JL, and Yang YY. Dual pH-Responsive Shell-Cleavable Polycarbonate Micellar Nanoparticles for in Vivo Anticancer Drug Delivery. ACS Appl Mater Interfaces. 2018 Jun 13;10(23):19355-19364. DOI:10.1021/acsami.8b01954 | Ma Y, He P, Tian X, Liu G, Zeng X, and Pan G. Mussel-Derived, Cancer-Targeting Peptide as pH-Sensitive Prodrug Nanocarrier. ACS Appl Mater Interfaces. 2019 Jul 10;11(27):23948-23956. DOI:10.1021/acsami.9b09031 | Li Y, Hong W, Zhang H, Zhang TT, Chen Z, Yuan S, Peng P, Xiao M, and Xu L. Photothermally triggered cytosolic drug delivery of glucose functionalized polydopamine nanoparticles in response to tumor microenvironment for the GLUT1-targeting chemo-phototherapy. J Control Release. 2020 Jan 10;317:232-245. DOI:10.1016/j.jconrel.2019.11.031 | Wang Z, Fang Y, Teague J, Wong H, Morisseau C, Hammock BD, Rock DA, and Wang Z. In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s. Drug Metab Dispos. 2017 Jul;45(7):712-720. DOI:10.1124/dmd.117.075226 | Zhang M, Lu L, Ying M, Ruan H, Wang X, Wang H, Chai Z, Wang S, Zhan C, Pan J, and Lu W. Enhanced Glioblastoma Targeting Ability of Carfilzomib Enabled by a (D)A7R-Modified Lipid Nanodisk. Mol Pharm. 2018 Jun 4;15(6):2437-2447. DOI:10.1021/acs.molpharmaceut.8b00270 | Tang SC, Nguyen LN, Sparidans RW, Wagenaar E, Beijnen JH, and Schinkel AH. Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar. Int J Cancer. 2014 Mar 15;134(6):1484-94. DOI:10.1002/ijc.28475 | Liu CC, Yamazaki Y, Heckman MG, Martens YA, Jia L, Yamazaki A, Diehl NN, Zhao J, Zhao N, DeTure M, Davis MD, Felton LM, Qiao W, Li Y, Li H, Fu Y, Wang N, Wren M, Aikawa T, Holm ML, Oue H, Linares C, Allen M, Carrasquillo MM, Murray ME, Petersen RC, Ertekin-Taner N, Dickson DW, Kanekiyo T, and Bu G. Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease. Alzheimers Dement. 2020 Oct;16(10):1372-1383. DOI:10.1002/alz.12104 | Zou L, Spanogiannopoulos P, Pieper LM, Chien HC, Cai W, Khuri N, Pottel J, Vora B, Ni Z, Tsakalozou E, Zhang W, Shoichet BK, Giacomini KM, and Turnbaugh PJ. Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018. DOI:10.1073/pnas.1920483117 | Zou L, Spanogiannopoulos P, Pieper LM, Chien HC, Cai W, Khuri N, Pottel J, Vora B, Ni Z, Tsakalozou E, Zhang W, Shoichet BK, Giacomini KM, and Turnbaugh PJ. Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018. DOI:10.1073/pnas.1920483117 | Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, and Tsujikawa K. Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer. Oncol Rep. 2021 Jan;45(1):309-316. DOI:10.3892/or.2020.7839 | 2019 Wang Z, Fang Y, Teague J, Wong H, Morisseau C, Hammock BD, Rock DA, Wang Z. In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s. Drug Metab Dispos. 2017 Jul;45(7):712-720 (PMID: 28428366) (1/22/19, 나은). Schäfer AM, Potterat O, Seibert I, Fertig O, Meyer Zu Schwabedissen HE. Hyperforin-Induced Activation of the Pregnane X Receptor Is Influenced by the Organic Anion-Transporting Polypeptide 2B1. Mol Pharmacol. 2019 Mar;95(3):313-323. (PMID: 30573512) (2/8/19, 지윤) Muchamuel T, Basler M, Aujay MA, Suzuki E, Kalim KW, Lauer C, Sylvain C, Ring ER, Shields J, Jiang J, Shwonek P, Parlati F, Demo SD, Bennett MK, Kirk CJ, Groettrup M. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat Med. 2009 Jul;15(7):781-7. doi: 10.1038/nm.1978. Epub 2009 Jun 14. Erratum in: Nat Med. 2009 Nov;15(11):1333. (PMID: 19525961) (3/5/19, 지수) Basseville A, Tamaki A, Ierano C, Trostel S, Ward Y, Robey RW, Hegde RS, Bates SE. Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter. Cancer Res. 2012 Jul 15;72(14):3642-51. (PMID: 22472121) (3/28/19, 정민) Liang J, Gao C, Zhu Y, Ling C, Wang Q, Huang Y, Qin J, Wang J, Lu W, Wang J. Natural Brain Penetration Enhancer-Modified Albumin Nanoparticles for Glioma Targeting Delivery. ACS Appl Mater Interfaces. 2018 Sep 12;10(36):30201-30213. (PMID: 30113810) (4/16/19, 혜령) Michael Zimmermann, Maria Zimmermann-Kogadeeva, Rebekka Wegmann, Andrew L. Goodman. Separating host and microbiome contributions to drug pharmacokinetics and toxicity. Science. 2019 Feb 8;363(6427). (PMID: 30733391) (5/3/19, 나은) Wagner LK, Gilling KE, Schormann E, Kloetzel PM, Heppner FL, Krüger E, Prokop S. Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice. Acta Neuropathol Commun. 2017 Jun 24;5(1):52. (PMID: 28646899) (6/4/19, 지수) Peng H, Zhu QS, Zhong S, Levy D. Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H1.2. Association with Sodium-Dependent Bile Acid Transport. PLoS One. 2015 May 20;10(5):e0125318. (PMID: 25992604) (6/21/19, 선아) Ripperger A, Benndorf RA. The C421A (Q141K) polymorphism enhances the 3'-untranslated region (3'-UTR)-dependent regulation of ATP-binding cassette transporter ABCG2. Biochem Pharmacol. 2016 Mar 15;104:139-47. (PMID: 26903388) (7/19/19, 정민) Jablonka L, Ashtikar M, Gao G, Jung F, Thurn M, Preuß A, Scheglmann D, Albrecht V, Röder B, Wacker MG. Advanced in silico modeling explains pharmacokinetics and biodistribution of temoporfin nanocrystals in humans.J Control Release. 2019 Jun 24;308:57-70. (PMID: 31247282) (8/2/19, 혜령) 2018 Sigfridsson K, Skantze P, Skantze U, Svensson L, Löfgren L, Nordell P, Michaëlsson E, Smedsrød B, Fuglesteg B, Elvevold K, Lindfors L. Nanocrystal formulations of a poorly soluble drug. 2. Evaluation of nanocrystal liver uptake and distribution after intravenous administration to mice. Int J Pharm. 2017;524(1-2):248-256. (1/11/18, 지은) Ashley JD, Stefanick JF, Schroeder VA, Suckow MA, Alves NJ, Suzuki R, Kikuchi S, Hideshima T, Anderson KC, Kiziltepe T, Bilgicer B. Liposomal carfilzomib nanoparticles effectively target multiple myeloma cells and demonstrate enhanced efficacy in vivo. J Control Release. 2014;196:113-21 (PMID: 25312543) (3/6/18, Yearin) Koslowski M1, Luxemburger U, Türeci O, Sahin U. Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α. Oncogene. 2011;30(7):876-82. (PMID: 21042279) (3/20/18, Naeun) Keiser M, Kaltheuner L, Wildberg C, Müller J, Grube M, Partecke LI, Heidecke CD, Oswald S. The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers. J Pharm Sci.2017;106(9):2657-2663. 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