Lauffenburger:Laura Sontag: Difference between revisions

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Computational and experimental analysis of mitogenic signaling pathways
Computational and experimental analysis of mitogenic signaling pathways
activated by mutations in the K-ras oncogene.  The Ras signaling cascade
activated by oncogenic Ras.  The Ras signaling cascade
constitutes a major pathway shown to be deregulated due to activating
constitutes a major pathway shown to be deregulated due to activating
mutations in 30% of all human tumors.  The vast majority of mutations occur in K-ras.  We use genetically engineered mice that harbor a conditional,
mutations in 30% of all human tumors.  The vast majority of mutations occur in K-ras.  We use genetically engineered mice that harbor a conditional,

Revision as of 14:34, 5 February 2006

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Laura Sontag (Computational and Systems Biology doctoral student)

Advisors: Professors Peter Sorger (Biology/BE, MIT) and Doug Lauffenburger (Biology/BE, MIT), in collaboration with Professor Tyler Jacks (Biology/Center for Cancer Research, MIT)


Computational and experimental analysis of mitogenic signaling pathways activated by oncogenic Ras. The Ras signaling cascade constitutes a major pathway shown to be deregulated due to activating mutations in 30% of all human tumors. The vast majority of mutations occur in K-ras. We use genetically engineered mice that harbor a conditional, activatable K-ras allele as a model of human cancer.


Email: sontag {AT} mit {DOT} edu

Laura Sontag's Homepage

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