Knipp lab:Publications

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Recent publications

1. Summary of the national institute of child health and human development-best pharmaceuticals for children act pediatric formulation initiatives workshop-pediatric biopharmaceutics classification system working group. Abdel-Rahman SM, Amidon GL, Kaul A, Lukacova V, Vinks AA, Knipp GT. Members of the BCS Task Force. Clin Ther. 2012 Nov;34(11):S11-24. doi:10.1016/j.clinthera.2012.09.014.

2. ABC and SLC Transporter Expression and Proton Oligopeptide Transporter (POT) Mediated Permeation across the Human Blood-Brain Barrier Cell Line, hCMEC/D3. Carl SM, Lindley DJ, Das D, Couraud PO, Weksler BB, Romero I, Mowery SA, Knipp GT. Mol Pharm. 2012 Nov 6. [Epub ahead of print] No abstract available.

3. Comparative pharmacokinetics studies of immediate- and modified-release formulations of glipizide in pigs and dogs. Kulkarni R, Yumibe N, Wang Z, Zhang X, Tang CC, Ruterbories K, Cox A, McCain R, Knipp GT. J Pharm Sci. 2012 Nov;101(11):4327-36. doi: 10.1002/jps.23292. Epub 2012 Aug 16.

4. The effects of intralaboratory modifications to media composition and cell source on the expression of pharmaceutically relevant transporters and metabolizing genes in the Caco-2 cell line. Roth WJ, Lindley DJ, Carl SM, Knipp GT. J Pharm Sci. 2012 Oct;101(10):3962-78. doi: 10.1002/jps.23241. Epub 2012 Jul 11.

5. Plasma Cortisol and Noradrenalin Concentrations in Pigs: Automated Sampling of Freely Moving Pigs Housed in the PigTurn® Versus Manually Sampled and Restrained Pigs. Marchant-Forde JN, Matthews DL, Poletto R, McCain RR, Mann DD, Degraw, RT, Hampsch JM, Peters S, Knipp GT, Kissinger CB. Anim. Welfare. 2012 May; 21(2):197-205(9).

6. The effects of media on pharmaceutically relevant transporters in the human HT-29 adenocarcinoma cell line: does culture media need to be controlled? Lindley DJ, Roth WJ, Carl SM, Knipp GT. J Pharm Sci. 2012 Apr;101(4):1616-30. doi: 10.1002/jps.23036. Epub 2011 Dec 28.

7. Assessing the performance of amorphous solid dispersions. Newman A, Knipp G, Zografi G. J Pharm Sci. 2012 Apr;101(4):1355-77. doi: 10.1002/jps.23031. Epub 2011 Dec 27. [Editors’ Picks on the J Pharm Sci website.]

8. The Evaluation of Peptide/Histidine Transporter 1 (PHT1) Function: Uptake Kinetics Utilizing a COS-7 Stably Transfected Cell Line. Lindley DJ, Carl SM, Mowery S, Knipp GT. Revista Mexicana De Ciencia Farmaceuticas. Octubre-Diciembre 2011; 42(4);57-65.

9. ABC and SLC transporter expression and pot substrate characterization across the human CMEC/D3 blood-brain barrier cell line. Carl SM, Lindley DJ, Couraud PO, Weksler BB, Romero I, Mowery SA, Knipp GT. Mol Pharm. 2010 Aug 2;7(4):1057-68.

10. The effects of excipients on transporter mediated absorption. Goole J, Lindley DJ, Roth W, Carl SM, Amighi K, Kauffmann JM, Knipp GT. Int J Pharm. 2010 Jun 30;393(1-2):17-31. Epub 2010 Apr 24.

11. Effect of placental fatty acid metabolism and regulation by peroxisome proliferator activated receptor on pregnancy and fetal outcomes. Xu Y, Wang Q, Cook TJ, Knipp GT. J Pharm Sci. 2007 Oct;96(10):2582-606.

12. The pharmacodynamic effects of sirolimus and sirolimus-calcineurin inhibitor combinations on macrophage scavenger and nuclear hormone receptors. Mathis AS, Jin S, Friedman GS, Peng F, Carl SM, Knipp GT. J Pharm Sci. 2007 Jan;96(1):209-22.

13. Di-(2-ethylhexyl)-phthalate affects lipid profiling in fetal rat brain upon maternal exposure. Xu Y, Agrawal S, Cook TJ, Knipp GT. Arch Toxicol. 2007 Jan;81(1):57-62. Epub 2006 Sep 2.


Book Chapters
Invited Chapter:
1. D.J. Lindley, S.M. Carl, D.R. Herrera-Ruiz, L.-F. Pan, L.B. Ward, J.M.E. Goole, O.S. Gudmundsson, and G.T. Knipp. Chapter 18: Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide Based Pharmaceuticals. In Oral Bioavailability: Basic Principles, Advanced Concepts and Application. Eds. M. Hu and X. Li. In the Wiley Series on Drug Discovery and Development, Series Ed. B. Wang, John Wiley & Sons, New York, NY. pp. 291-308 (2011).

2. S.M. Carl, D.J. Lindley, G.T. Knipp, K.R. Morris, E. Oliver, G.W. Becker and R.A. Arnold. Biotechnology Drug Product Development. In Pharmaceutical Manufacturing Handbook, Editor S.H. Gad, John Wiley & Sons, New York, NY, pp. 1-32 (2008). [DOI: 10.1002/9780470259818.ch1; Republished in a Wiley Special Edition Series “Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and Manufacturing.” DOI: 10.1002/9780470571224.pse340 1-26 (2010)].

3. E. Oliver, S.M. Carl, K.R. Morris, G.W. Becker and G.T. Knipp. Regulatory Considerations in the Approval of Follow-On Protein Drug Products. In Pharmaceutical Manufacturing Handbook, Editor S.H. Gad, John Wiley & Sons, New York, NY, pp. 33-57 (2008). [DOI: 10.1002/9780470259818.ch2; Republished in a Wiley Special Edition Series entitled “Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and Manufacturing.” 1–32 (2010)].

4. S.M. Carl, D.J. Lindley, G.T. Knipp, K.R. Morris, E. Oliver, G.W. Becker and R.A. Arnold, Biotechnology Drug Product Development. In Pharmaceutical Manufacturing Handbook, Editor S.H. Gad, John Wiley & Sons, New York, NY, pp. 1-32 (2008).

5. E. Oliver, S.M. Carl, K.R. Morris, G.W. Becker and G.T. Knipp. Regulatory Considerations in the Approval of Follow On Protein Drug Products. In Pharmaceutical Manufacturing Handbook, Editor S.H. Gad, John Wiley & Sons, New York, NY, pp. 33-57 (2008).

6. R.K. Bhardwaj, D.R. Herrera-Ruiz, Y. Xu, S.M. Carl, T.J. Cook, N. Vorsa, and G.T. Knipp. Chapter 7: Intestinal Transporters in Drug Absorption. In Biopharmaceutics Applications in Drug Development. Editors R. Krishna and L. Yu, Kluwer Press, NY, pp. 175-261 (2008).

7. S.M. Carl, D.R. Herrera-Ruiz, R.K. Bhardwaj, O.S. Gudmundsson, and G.T. Knipp. Chapter 6: Mammalian Oligopeptide Transporters. In Drug Transporters: Molecular Characterization and Role in Drug Disposition. Editors G. You and M. Morris. John Wiley & Sons, New York, NY. pp. 105-146 (2007).


Edited Textbook Chapters
Martin’s Physical Pharmacy and Pharmaceutical Sciences, Fifth Edition. Editor Patrick J. Sinko. Lippincott, Williams & Wilkins, Baltimore, MD, (2006).

1. G.T. Knipp and K.R. Morris, Chapter 2: States of Matter.

2. H. Morelos, D. Herrera-Ruiz, and G.T. Knipp, Chapter 3: Thermodynamics.

3. G.T. Knipp, H. Morelos and D. Herrera-Ruiz, Chapter 4: Physical Properties of Drug Molecules.


Refereed Abstracts
1. N. Yumibe, R. Kulkarni, Z. Wang, X. Zhang, K. Ruterbories, A. Cox, R. Ajamie, C.C. Tang, G. Knipp, Robin McCain. Comparative Pharmacokinetic Studies of Immediate and Modified Release Formulations of Glipizide in Pigs and Dogs. 2011 AAPS Indiana/Ohio Discussion Group-Pharma Industry Challenges/Perspectives Symposium, Indianapolis, IN. (2011).

2. W.J. Roth, C.B. Kissinger, S. Hannou, B.R. Cooper, R.R. McCain, R. Vreeman, and G.T. Knipp. Development and Testing of Novel Pediatric Formulation of Rifampicin for the Treatment of Tuberculosis (TB) in Infants and Young Children. 2011 AAPS Indiana/Ohio Discussion Group-Pharma Industry Challenges/Perspectives Symposium, Indianapolis, IN. (2011). Best Poster Award.


Posters
C.D. Kulczar and G.T. Knipp. Juvenile Pigs as Surrogates for Human Pediatrics During Preclinical Pharmacokinetic Testing: A Possible Means to Expedite Pediatric Drug Development?" 2012 PGSRM Best Poster.

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