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<h3>Overview</h3>
<h3>Overview</h3>
Our research spans the disciplinary boundaries between biomechanics, nanotechnology, and cell biology with an emphasis on their applications to tissue engineering and regenerative medicine. We focus on the development and applications of biomimetic cell culture models and advanced tissue engineering constructs for high-throughput drug screening, stem cell-based therapies, disease diagnostics, and medical device development. Using engineered microenvironments in combination with live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health.  
Our research spans the disciplinary boundaries between biomechanics, nanotechnology, and cell biology with an emphasis on their applications to tissue engineering and regenerative medicine. We focus on the development and applications of biomimetic cell culture models and tissue engineering constructs for high-throughput drug screening, stem cell-based therapies, disease diagnostics, and medical device development. Using engineered microenvironments in combination with live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health.  
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Revision as of 01:46, 13 September 2010

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Overview

Our research spans the disciplinary boundaries between biomechanics, nanotechnology, and cell biology with an emphasis on their applications to tissue engineering and regenerative medicine. We focus on the development and applications of biomimetic cell culture models and tissue engineering constructs for high-throughput drug screening, stem cell-based therapies, disease diagnostics, and medical device development. Using engineered microenvironments in combination with live cell imaging approaches, we are also studying the interplay between mechanical and biochemical signaling in the regulation of cell function and fate decisions that are essential for tissue repair and regeneration following injury, and various developmental events. The ultimate goal of our research is to better understand complex cellular behavior in response to microenvironmental cues in normal, aging and disease states, to gain new mechanistic insights into the control of cell-tissue structure and function, and to develop multiscale regenerative technologies for improving human health.

News

  • 07/30/2010 Professor Kim featured in National Institute of Biomedical Imaging and Bioengineering article on a nanoengineered patch for the damaged heart [1]
  • 05/07/2010 Professor Kim received the Harold M. Weintraub Award [2]
  • 12/17/2009 PNAS paper discussed in Science Daily magazine [3]
  • 05/18/2009 Advanced Functional Materials paper featured as Frontispiece [4]

Recent Publications

  • D.H. Kim, H.J. Lee, Y.K. Lee, J.M. Nam, and A. Levchenko, "Biomimetic nanopatterns as enabling tools for analysis and control of live cells," Advanced Materials, 2010. Pubmed, Hubmed
  • D.H. Kim, E. Lipke, P. Kim, R. Cheong, S. Edmonds, M. Delannoy, K.Y. Suh, L.Tung, and A. Levchenko, "Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs," Proceedings of National Academy of Sciences USA, vol.107, pp. 565-570, 2010. Pubmed, Hubmed
  • D.H. Kim, P. Wong, J.Y. Park, A. Levchenko, and Y. Sun, "Microengineered platform for cell mechanobiology," Annual Review of Biomedical Engineering, vol. 11, pp.203-233, 2009. Pubmed


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