Kevin Matthew McKay Week 5

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(link to glutamate pathway)
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*L-GLutamate is involved in 56 pathways
*L-GLutamate is involved in 56 pathways
*[[http://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=PWY3O-13&detail-level=4&detail-level=3 - glutamate pathway]]
*[[http://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=PWY3O-13&detail-level=4&detail-level=3 - glutamate pathway]]
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*[[Image:Screen Shot 2013-02-13 at 5.42.55 PM.png|Screenshot]]
[[Category:BIOL398-03/S13]]
[[Category:BIOL398-03/S13]]

Revision as of 20:45, 13 February 2013

Genes

  • GDH1
    • 2 Homo sapien Homologues:
      • 1NR1 and 1L1F
        • Deficiency in 1L1F causes hyperinsulinism/hymerammonemia syndrome
    • Expression is regulated by carbon sources
      • High expression in presence of glucose and ethanol
  • GDH3
    • 2 Homo sapien Homologues:
      • 1NR1 and 1L1F
        • Deficiency in 1L1F causes hyperinsulinism/hymerammonemia syndrome
    • Expression regulated by carbon sources
      • High expression in presence of ethanol, repressed by glucose
  • GDH2
    • Homo Sapien Homolog:
      • GLUD2
        • Deficiency causes hyperinsulinism
    • Expression regulated by nitrogen catabolite repression and intracellular ammonia levels
  • GLN1
    • Homo sapien homologues:
    • 2OJW and 2QC8
      • Changes in activity of these genes has been linked to Alzheimer's disease
    • Expression regulated by nitrogen source and amino acid limitation
  • GLT1
    • No Homo sapien homolog
    • Expression regulated by glutamate-mediated repression and GLN3P/GCN4P-mediated activation, availability of nitrogen and glutamate, and when amino acids are limiting, GLT1 expression is activated by GCN4P.
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